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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by de Bruijn, M. F. T. R. Articles by Dzierzak, E. Search for Related Content PubMed PubMed Citation Articles by de Bruijn, M. F. T. R. Articles by Dzierzak, E. Related Collections Hematopoiesis and Stem Cells Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 October 2000, Vol. 96, No. 8, pp. 2902-2904 BRIEF REPORT CFU-S11 activity does not localize solely with the aorta in the aorta-gonad-mesonephros region Marella F. T. R. de Bruijn, Marian C. E. Peeters, Tanya Luteijn, Pim Visser, Nancy A. Speck, and Elaine Dzierzak From the Department of Cell Biology and Genetics and the Department of Clinical Genetics, Erasmus University, Rotterdam, The Netherlands, and the Department of Biochemistry, Dartmouth Medical School, Hanover, NH. The aorta-gonad-mesonephros (AGM) region is a potent hematopoietic site in the midgestation mouse conceptus and first contains colony-forming units-spleen day 11 (CFU-S11) at embryonic day 10 (E10). Because CFU-S11 activity is present in the AGM region before the onset of hematopoietic stem cell (HSC) activity, CFU-S11 activity in the complex developing vascular and urogenital regions of the AGM was localized. From E10 onward, CFU-S11 activity is associated with the aortic vasculature, and is found also in the urogenital ridges (UGRs). Together with data obtained from organ explant cultures, in which up to a 16-fold increase in CFU-S11 activity was observed, it was determined that CFU-S11 can be increased autonomously both in vascular sites and in UGRs. Furthermore, CFU-S11 activity is present in vitelline and umbilical vessels. This, together with the presence of CFU-S11 in the UGRs 2 days before HSC activity, suggests both temporally and spatially distinct emergent sources of CFU-S11. © 2000 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Yao, B. Liu, X. Wang, Y. Lan, N. Hou, X. Yang, and N. Mao Identification of High Proliferative Potential Precursors with Hemangioblastic Activity in the Mouse Aorta-Gonad- Mesonephros Region Stem Cells, June 1, 2007; 25(6): 1423 - 1430. [Abstract] [Full Text] [PDF] S. Taoudi and A. Medvinsky Functional identification of the hematopoietic stem cell niche in the ventral domain of the embryonic dorsal aorta PNAS, May 29, 2007; 104(22): 9399 - 9403. [Abstract] [Full Text] [PDF] A. Robert-Moreno, L. Espinosa, J. L. de la Pompa, and A. Bigas RBPj{kappa}-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells Development, March 1, 2005; 132(5): 1117 - 1126. [Abstract] [Full Text] [PDF] R. A. J. Oostendorp, A. J. Medvinsky, N. Kusadasi, N. Nakayama, K. Harvey, C. Orelio, K. Ottersbach, T. Covey, R. E. Ploemacher, C. Saris, et al. Embryonal subregion-derived stromal cell lines from novel temperature-sensitive SV40 T antigen transgenic mice support hematopoiesis J. Cell Sci., May 15, 2002; 115(10): 2099 - 2108. [Abstract] [Full Text] [PDF]

	Copyright © 2000 by American Society of Hematology         Online ISSN: 1528-0020