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Blood, 1 November 2000, Vol. 96, No. 9, pp. 3279-3281
BRIEF REPORT
Molecular evidence of organ-related transmission of Kaposi
sarcoma-associated herpesvirus or human herpesvirus-8 in
transplant patients
Mario Luppi,
Patrizia Barozzi,
Gaia Santagostino,
Raffaella Trovato,
Thomas F. Schulz,
Roberto Marasca,
Davide Bottalico,
Lucia Bignardi, and
Giuseppe Torelli
From the Department of Medical Sciences, Section of
Hematology, University of Modena and Division of Nephrology, University
of Parma, Italy; and Department of Medical Microbiology and
Genitourinary Medicine, University of Liverpool, UK.
In transplant patients, Kaposi sarcoma (KS)-associated herpesvirus
or human herpesvirus-8 (HHV-8) infection is associated with the
development of KS, primary effusion lymphoma and Castleman disease.
Whether HHV-8 is either reactivated in the recipient or transmitted by
the donor has been investigated so far only by serologic studies. Thus,
we addressed the issue of HHV-8 transmission in the transplantation
setting by molecular methods. We exploited the high level variability
of the orf-K1 gene and the polymorphism of the
orf-73 gene of the HHV-8 genome to assess the genetic
relatedness of the HHV-8 strains identified in the posttransplant KS
lesions that developed, simultaneously, 20 months after
transplantation, in 2 recipients of twin kidneys from the same cadaver
donor. The 100% identity of nucleotide sequence of the most
variable viral region and the presence of the same, single
orf-73 type in both patients provides strong molecular
evidence of organ-related transmission of HHV-8 in the setting of transplantation.
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