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Blood, 1 November 2000, Vol. 96, No. 9, pp. 3282-3285
BRIEF REPORT
Adhesion to 90K (Mac-2 BP) as a mechanism for lymphoma drug
resistance in vivo
Bruna Fornarini,
Consuelo D'Ambrosio,
Clara Natoli,
Nicola Tinari,
Vittorio Silingardi, and
Stefano Iacobelli
From the Department of Oncology and Neurosciences,
University G. D'Annunzio Medical School, Chieti, Italy; and the
Department of Medical, Oncological and Radiological Sciences,
University of Modena and Reggio Emilia Medical School, Modena, Italy.
A cell-adhesive protein of the human serum, 90K binds galactin-3,
 1-integrins, collagens, and fibronectin, and it is of importance in
cell-cell and cell-extracellular matrix adhesion. Serum 90K levels in
137 patients with lymphoma were measured by enzyme-linked immunosorbent
assay. Compared with healthy controls, pretreatment serum 90K levels in
patients with lymphoma were elevated (P < .001). Of 97 patients who showed objective response to treatment, 20 (21%) had
pretreatment 90K levels above the normal cutoff compared with 17 (53%)
of 32 patients who did not respond (P = .002). When used
as a plastic-immobilized substrate, 90K caused a significant reduction
in chemotherapy-induced apoptosis of Jurkat T lymphoma cells. This
finding could explain the lack of response in lymphoma patients with
high 90K serum levels.
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