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Blood, 1 November 2000, Vol. 96, No. 9, pp. 3290-3293
BRIEF REPORT
Low B-cell and monocyte counts on day 80 are associated with high
infection rates between days 100 and 365 after allogeneic marrow
transplantation
Jan Storek,
German Espino,
Monja A. Dawson,
Barry Storer,
Mary E. D. Flowers, and
David G. Maloney
From the Fred Hutchinson Cancer Research Center and University
of Washington, Seattle, WA.
To ascertain which mononuclear cell subset deficiency plays a role
in the marrow transplant recipient's susceptibility to infections,
mononuclear cell subset counts were prospectively determined in 108 patients on day 80. Infections occurring between day 100 and 365 were
recorded by an investigator blinded to the subset counts. In univariate
analyses, the counts of the following subsets showed a significant
inverse correlation with infection rates: total B cells,
IgD+ B cells, IgD B cells, total CD4 T cells,
CD28+ CD4 T cells, CD28 CD4 T cells,
CD45RAlow/ CD4 T cells and monocytes. In
multivariate analyses, the counts of the following subsets
remained significantly inversely correlated with the infection rates:
total B cells (P = .0004) and monocytes (P = .009). CD28 CD8 T-cell counts showed
no correlation with infection rates. In conclusion, the susceptibility
of patients to infections late posttransplant may be due in part to the
slow reconstitution of B cells and monocytes.
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