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Related Collections Hemostasis, Thrombosis, and Vascular Biology Cell Adhesion and Motility Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 January 2001, Vol. 97, No. 1, pp. 162-168 HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Ristocetin-dependent, but not botrocetin-dependent, binding of von Willebrand factor to the platelet glycoprotein Ib-IX-V complex correlates with shear-dependent interactions Jing-Fei Dong, Michael C. Berndt, Alicia Schade, Larry V. McIntire, Robert K. Andrews, and José A. López From the Departments of Medicine and Molecular and Human Genetics, Baylor College of Medicine, and the Cox Laboratory for Biomedical Engineering, Rice University, Houston, TX; and the Hazel and Pip Appel Vascular Biology Laboratory, Baker Medical Research Institute, Melbourne, Australia. Under conditions of high shear stress, both hemostasis and thrombosis are initiated by the interaction of the platelet membrane glycoprotein (GP) Ib-IX-V complex with its adhesive ligand, von Willebrand factor (vWF), in the subendothelial matrix or plasma. This interaction involves the A1 domain of vWF and the N-terminal extracellular region of GP Ib (His-1-Glu-282), and it can also be induced under static conditions by the modulators ristocetin and botrocetin. In this study, a panel of anti-vWF and anti-GP Ib antibodiespreviously characterized for their effects on ristocetin- and botrocetin-dependent vWF-GP Ib-IX-V interactionswas analyzed for their capacity to inhibit either the adhesion of Chinese hamster ovary cells expressing recombinant GP Ib to surface-associated vWF under hydrodynamic flow or shear-stress-induced platelet aggregation. The combined results suggest that the shear-dependent interactions between vWF and GP Ib closely correlate with ristocetin- rather than botrocetin-dependent binding under static conditions and that certain anti-vWF monoclonal antibodies are able to selectively inhibit shear-dependent platelet aggregation. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. A. Berny, T. C. White, E. I. Tucker, L. A. Bush-Pelc, E. Di Cera, A. Gruber, and O. J.T. McCarty Thrombin Mutant W215A/E217A Acts as a Platelet GPIb Antagonist Arterioscler Thromb Vasc Biol, February 1, 2008; 28(2): 329 - 334. [Abstract] [Full Text] [PDF] H. Choi, K. Aboulfatova, H. J. Pownall, R. Cook, and J.-f. Dong Shear-induced Disulfide Bond Formation Regulates Adhesion Activity of von Willebrand Factor J. Biol. Chem., December 7, 2007; 282(49): 35604 - 35611. [Abstract] [Full Text] [PDF] H. Ulrichts, M. Udvardy, P. J. Lenting, I. Pareyn, N. Vandeputte, K. Vanhoorelbeke, and H. Deckmyn Shielding of the A1 Domain by the D'D3 Domains of von Willebrand Factor Modulates Its Interaction with Platelet Glycoprotein Ib-IX-V J. Biol. Chem., February 24, 2006; 281(8): 4699 - 4707. [Abstract] [Full Text] [PDF] G. Lasser, P. Guchhait, J. L. Ellsworth, P. Sheppard, K. Lewis, P. Bishop, M. A. Cruz, J. A. Lopez, and J. Fruebis C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen Blood, January 15, 2006; 107(2): 423 - 430. [Abstract] [Full Text] [PDF] Y. Peng, C. N. Shrimpton, J.-f. Dong, and J. A. Lopez Gain of von Willebrand factor-binding function by mutagenesis of a species-conserved residue within the leucine-rich repeat region of platelet glycoprotein Ib{alpha} Blood, September 15, 2005; 106(6): 1982 - 1987. [Abstract] [Full Text] [PDF] Y. Peng, M. C. Berndt, M. A. Cruz, and J. A. 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Romo, N. T. Turner, L. V. McIntire, and J. A. Lopez Tyrosine Sulfation of Glycoprotein Ibalpha . ROLE OF ELECTROSTATIC INTERACTIONS IN VON WILLEBRAND FACTOR BINDING J. Biol. Chem., May 11, 2001; 276(20): 16690 - 16694. [Abstract] [Full Text] [PDF] F. A. Baglia, K. O. Badellino, C. Q. Li, J. A. Lopez, and P. N. Walsh Factor XI Binding to the Platelet Glycoprotein Ib-IX-V Complex Promotes Factor XI Activation by Thrombin J. Biol. Chem., January 11, 2002; 277(3): 1662 - 1668. [Abstract] [Full Text] [PDF]

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