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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Skinnider, B. F. Articles by Mak, T. W. Search for Related Content PubMed PubMed Citation Articles by Skinnider, B. F. Articles by Mak, T. W. Related Collections Immunobiology Neoplasia Related Letter in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 January 2001, Vol. 97, No. 1, pp. 250-255 NEOPLASIA Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma Brian F. Skinnider, Andrew J. Elia, Randy D. Gascoyne, Lorenz H. Trümper, Frederike von Bonin, Ursula Kapp, Bruce Patterson, Bryan E. Snow, and Tak W. Mak From the Amgen Institute, Ontario Cancer Institute, the Department of Medical Biophysics, and the Department of Immunology, University of Toronto, Ontario, Canada; the Department of Pathology, British Columbia Cancer Agency, Vancouver, British Columbia, Canada; the Department of Internal Medicine I, University of Saarland, Homburg, Germany; the Department of Hematology/Oncology, University Medical Center, Freiburg, Germany; and the Department of Oncologic Pathology, Ontario Cancer Institute, Toronto, Ontario, Canada. Hodgkin lymphoma (HL) is characterized by the abnormal expression of multiple cytokines, accounting for its unique clinicopathologic features. We have previously shown that interleukin-13 (IL-13) is secreted by HL cell lines and may serve as an autocrine growth factor. To determine the frequency of IL-13 expression in lymphoma patients, tissue sections from 36 patients with classical HL, 5 patients with nodular lymphocyte predominance HL (NLPHL), and 23 patients with non-Hodgkin lymphoma (NHL) were subjected to in situ hybridization. In 31 of 36 cases (86%) of classical HL patients of all histologic subtypes, between 25% to almost 100% of Hodgkin and Reed Sternberg (HRS) cells were positive for IL-13 expression. In contrast, in no case of NLPHL and in only 4 of 23 NHL cases (1 of 5 T-cell-rich B-cell lymphomas, 2 of 5 anaplastic large cell lymphomas, and 1 of 5 peripheral T-cell lymphomas) did the neoplastic cells express IL-13. The expression of the IL-13 receptor chain 1 (IL-13R1) was also analyzed by in situ hybridization. In 24 of 27 (89%) cases of classical HL, between 25% to 75% of HRS cells, as well as a high frequency of lymphocytes and histiocytes, were positive for IL-13R1 expression. These results were confirmed by the construction of complementary DNA libraries from single HRS cells, followed by polymerase chain reaction analysis, in which IL-13R1 transcripts were found to be present in all 6 cases of HL. These data indicate that expression of IL-13 and IL-13R1 is a common feature of HRS cells in HL, consistent with the hypothesis that IL-13 may play a role in autocrine growth in classical HL. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Letter in Blood Online: Interleukin-13 levels in serum from patients with Hodgkin disease and healthy volunteers Paolo Fiumara, Fernando Cabanillas, and Anas Younes Blood 2001 98: 2877-2878. [Full Text] [PDF] This article has been cited by other articles: O. Ritz, C. Guiter, F. Castellano, K. Dorsch, J. Melzner, J.-P. Jais, G. Dubois, P. Gaulard, P. Moller, and K. 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	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020