SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tiberghien, P. Articles by Cahn, J.-Y. Search for Related Content PubMed PubMed Citation Articles by Tiberghien, P. Articles by Cahn, J.-Y. Related Collections Transplantation Immunotherapy Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 January 2001, Vol. 97, No. 1, pp. 63-72 CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft Pierre Tiberghien, Christophe Ferrand, Bruno Lioure, Noël Milpied, Régis Angonin, Eric Deconinck, Jean-Marie Certoux, Eric Robinet, Philippe Saas, Bruno Petracca, Chris Juttner, Craig W. Reynolds, Dan L. Longo, Patrick Hervé, and Jean-Yves Cahn From the Etablissement Français du Sang, Bourgogne/Franche-Comté, and Service d'Anatomie Pathologique and Service d'Hématologie, Centre Hospitolier Universitoire (CHU) Besançon, Besançon, France; Service d'Hématologie, CHU Strasbourg, Strasbourg, France; Service d'Hématologie, CHU Nantes, Nantes, France; Genetic Therapy Inc. (GTI)/Systemix/Novartis, Palo Alto, CA; National Cancer Institute (NCI)-FCRDC, National Institutes of Health (NIH), Frederick, MD; and the National Institute on Aging, NIH, Baltimore, MD. Administration of donor T cells expressing the herpes simplex-thymidine kinase (HS-tk) with a hematopoietic stem cell (HSC) transplantation could allow, if graft-versus-host disease (GVHD) was to occur, a selective in vivo depletion of these T cells by the use of ganciclovir (GCV). The study evaluates the feasibility of such an approach. Escalating numbers of donor HS-tk-expressing CD3+ gene-modified cells (GMCs) are infused with a T-cell-depleted bone marrow transplantation (BMT). Twelve patients with hematological malignancies received 2 × 105 (n = 5), 6 × 105 (n = 5), or 20 × 105 (n = 2) donor CD3+ GMCs/kg with a BMT from a human leukocyte antigen (HLA)-identical sibling. No acute toxicity was associated with GMC administration. An early increase of circulating GMCs followed by a progressive decrease and long-lasting circulation of GMCs was documented. GCV treatment resulted in significant rapid decrease in circulating GMCs. Three patients developed acute GVHD, with a grade of at least II, while one patient developed chronic GVHD. Treatment with GCV alone was associated with a complete remission (CR) in 2 patients with acute GVHD, while the addition of glucocorticoids was necessary to achieve a CR in the last case. Long-lasting CR occurred with GCV treatment in the patient with chronic GVHD. Unfortunately, Epstein-Barr virus-lymphoproliferative disease occurred in 3 patients. Overall, the administration of low numbers of HS-tk-expressing T cells early following an HLA-identical BMT is associated with no acute toxicity, persistent circulation of the GMCs, and GCV-sensitive GVHD. Such findings open the way to the infusion of higher numbers of gene-modified donor T cells to enhance post-BMT immune competence while preserving GCV-sensitive alloreactivity. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. J. Shu, C. G. Radu, S. M. Shelly, D. D. Vo, R. Prins, A. Ribas, M. E. Phelps, and O. N. Witte Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen Int. Immunol., February 1, 2009; 21(2): 155 - 165. [Abstract] [Full Text] [PDF] S. Kaneko, S. Mastaglio, A. Bondanza, M. Ponzoni, F. Sanvito, L. Aldrighetti, M. Radrizzani, S. La Seta-Catamancio, E. Provasi, A. Mondino, et al. IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes Blood, January 29, 2009; 113(5): 1006 - 1015. [Abstract] [Full Text] [PDF] S. Newrzela, K. Cornils, Z. Li, C. Baum, M. H. Brugman, M. Hartmann, J. Meyer, S. Hartmann, M.-L. Hansmann, B. Fehse, et al. Resistance of mature T cells to oncogene transformation Blood, September 15, 2008; 112(6): 2278 - 2286. [Abstract] [Full Text] [PDF] M. A. de Witte, A. Jorritsma, E. Swart, K. C. Straathof, K. de Punder, J. B. A. G. Haanen, C. M. Rooney, and T. N. M. Schumacher An Inducible Caspase 9 Safety Switch Can Halt Cell Therapy-Induced Autoimmune Disease J. Immunol., May 1, 2008; 180(9): 6365 - 6373. [Abstract] [Full Text] [PDF] E. Kieback, J. Charo, D. Sommermeyer, T. Blankenstein, and W. Uckert A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer PNAS, January 15, 2008; 105(2): 623 - 628. [Abstract] [Full Text] [PDF] M. Deschamps, P. Mercier-Lethondal, J. M. Certoux, C. Henry, B. Lioure, C. Pagneux, J. Y. Cahn, E. Deconinck, E. Robinet, P. Tiberghien, et al. Deletions within the HSV-tk transgene in long-lasting circulating gene-modified T cells infused with a hematopoietic graft Blood, December 1, 2007; 110(12): 3842 - 3852. [Abstract] [Full Text] [PDF] P. Tiberghien Altruistic donor T cells Blood, June 1, 2007; 109(11): 4595 - 4595. [Full Text] [PDF] F. Ciceri, C. Bonini, S. Marktel, E. Zappone, P. Servida, M. Bernardi, A. Pescarollo, A. Bondanza, J. Peccatori, S. Rossini, et al. Antitumor effects of HSV-TK engineered donor lymphocytes after allogeneic stem-cell transplantation Blood, June 1, 2007; 109(11): 4698 - 4707. [Abstract] [Full Text] [PDF] R. Yanez, M. L. Lamana, J. Garcia-Castro, I. Colmenero, M. Ramirez, and J. A. Bueren Adipose Tissue-Derived Mesenchymal Stem Cells Have In Vivo Immunosuppressive Properties Applicable for the Control of the Graft-Versus-Host Disease Stem Cells, November 1, 2006; 24(11): 2582 - 2591. [Abstract] [Full Text] [PDF] P. J. Amrolia, G. Muccioli-Casadei, H. Huls, S. Adams, A. Durett, A. Gee, E. Yvon, H. Weiss, M. Cobbold, H. B. Gaspar, et al. Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation Blood, September 15, 2006; 108(6): 1797 - 1808. [Abstract] [Full Text] [PDF] C. Berger, M. E. Flowers, E. H. Warren, and S. R. Riddell Analysis of transgene-specific immune responses that limit the in vivo persistence of adoptively transferred HSV-TK-modified donor T cells after allogeneic hematopoietic cell transplantation Blood, March 15, 2006; 107(6): 2294 - 2302. [Abstract] [Full Text] [PDF] A. Bondanza, V. Valtolina, Z. Magnani, M. Ponzoni, K. Fleischhauer, M. Bonyhadi, C. Traversari, F. Sanvito, S. Toma, M. Radrizzani, et al. Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes Blood, March 1, 2006; 107(5): 1828 - 1836. [Abstract] [Full Text] [PDF] A. Recchia, C. Bonini, Z. Magnani, F. Urbinati, D. Sartori, S. Muraro, E. Tagliafico, A. Bondanza, M. T. L. Stanghellini, M. Bernardi, et al. Retroviral vector integration deregulates gene expression but has no consequence on the biology and function of transplanted T cells PNAS, January 31, 2006; 103(5): 1457 - 1462. [Abstract] [Full Text] [PDF] J. D. Roback Vaccine-Enhanced Donor Lymphocyte Infusion (veDLI) Hematology, January 1, 2006; 2006(1): 486 - 491. [Abstract] [Full Text] [PDF] C. Hsu, M. S. Hughes, Z. Zheng, R. B. Bray, S. A. Rosenberg, and R. A. Morgan Primary Human T Lymphocytes Engineered with a Codon-Optimized IL-15 Gene Resist Cytokine Withdrawal-Induced Apoptosis and Persist Long-Term in the Absence of Exogenous Cytokine J. Immunol., December 1, 2005; 175(11): 7226 - 7234. [Abstract] [Full Text] [PDF] K. C. Straathof, M. A. Pule, P. Yotnda, G. Dotti, E. F. Vanin, M. K. Brenner, H. E. Heslop, D. M. Spencer, and C. M. Rooney An inducible caspase 9 safety switch for T-cell therapy Blood, June 1, 2005; 105(11): 4247 - 4254. [Abstract] [Full Text] [PDF] B. Fehse, F. A. Ayuk, N. Kroger, L. Fang, K. Kuhlcke, M. Heinzelmann, T. Zabelina, A. A. Fauser, and A. R. Zander Evidence for increased risk of secondary graft failure after in vivo depletion of suicide gene-modified T lymphocytes transplanted in conjunction with CD34+-enriched blood stem cells Blood, November 15, 2004; 104(10): 3408 - 3409. [Full Text] [PDF] M. P. Rettig, J. K. Ritchey, J. L. Prior, J. S. Haug, D. Piwnica-Worms, and J. F. DiPersio Kinetics of In Vivo Elimination of Suicide Gene-Expressing T Cells Affects Engraftment, Graft-versus-Host Disease, and Graft-versus-Leukemia after Allogeneic Bone Marrow Transplantation J. Immunol., September 15, 2004; 173(6): 3620 - 3630. [Abstract] [Full Text] [PDF] P. Schelling, M. T. Claus, R. Johner, V. E. Marquez, G. E. Schulz, and L. Scapozza Biochemical and Structural Characterization of (South)-Methanocarbathymidine That Specifically Inhibits Growth of Herpes Simplex Virus Type 1 Thymidine Kinase-transduced Osteosarcoma Cells J. Biol. Chem., July 30, 2004; 279(31): 32832 - 32838. [Abstract] [Full Text] [PDF] C. Berger, C. A. Blau, M.-L. Huang, J. D. Iuliucci, D. C. Dalgarno, J. Gaschet, S. Heimfeld, T. Clackson, and S. R. Riddell Pharmacologically regulated Fas-mediated death of adoptively transferred T cells in a nonhuman primate model Blood, February 15, 2004; 103(4): 1261 - 1269. [Abstract] [Full Text] [PDF] J. D. Roback, M. S. Hossain, L. Lezhava, J. W. Gorechlad, S. A. Alexander, D. L. Jaye, S. Mittelstaedt, S. Talib, J. E. Hearst, C. D. Hillyer, et al. Allogeneic T Cells Treated with Amotosalen Prevent Lethal Cytomegalovirus Disease without Producing Graft-versus-Host Disease Following Bone Marrow Transplantation J. Immunol., December 1, 2003; 171(11): 6023 - 6031. [Abstract] [Full Text] [PDF] D. Sauce, N. Rufer, P. Mercier, M. Bodinier, J.-P. Remy-Martin, A. Duperrier, C. Ferrand, P. Herve, P. Romero, F. Lang, et al. Retrovirus-mediated gene transfer in polyclonal T cells results in lower apoptosis and enhanced ex vivo cell expansion of CMV-reactive CD8 T cells as compared with EBV-reactive CD8 T cells Blood, August 15, 2003; 102(4): 1241 - 1248. [Abstract] [Full Text] [PDF] W. R. Drobyski, M. Gendelman, S. Vodanovic-Jankovic, and J. Gorski Elimination of Leukemia in the Absence of Lethal Graft-Versus-Host Disease After Allogenic Bone Marrow Transplantation J. Immunol., March 15, 2003; 170(6): 3046 - 3053. [Abstract] [Full Text] [PDF] S. Marktel, Z. Magnani, F. Ciceri, S. Cazzaniga, S. R. Riddell, C. Traversari, C. Bordignon, and C. Bonini Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation Blood, February 15, 2003; 101(4): 1290 - 1298. [Abstract] [Full Text] [PDF] C. Berger, C. A. Blau, T. Clackson, S. R. Riddell, and S. Heimfeld CD28 costimulation and immunoaffinity-based selection efficiently generate primary gene-modified T cells for adoptive immunotherapy Blood, January 15, 2003; 101(2): 476 - 484. [Abstract] [Full Text] [PDF] E. Litvinova, S. Maury, O. Boyer, S. Bruel, L. Benard, G. Boisserie, D. Klatzmann, and J. L. Cohen Graft-versus-leukemia effect after suicide-gene-mediated control of graft-versus-host disease Blood, August 28, 2002; 100(6): 2020 - 2025. [Abstract] [Full Text] [PDF] D. Sauce, M. Bodinier, M. Garin, B. Petracca, N. Tonnelier, A. Duperrier, J. V. Melo, J. F. Apperley, C. Ferrand, P. Herve, et al. Retrovirus-mediated gene transfer in primary T lymphocytes impairs their anti-Epstein-Barr virus potential through both culture-dependent and selection process-dependent mechanisms Blood, February 15, 2002; 99(4): 1165 - 1173. [Abstract] [Full Text] [PDF] V. T. Ho and R. J. Soiffer The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantation Blood, December 1, 2001; 98(12): 3192 - 3204. [Full Text] [PDF] G. E. Georges, R. Storb, B. Bruno, S. J. Brodie, J. D. Thompson, A. G. Taranova, J. M. Zaucha, M.-T. Little, E. Zellmer, P. F. Moore, et al. Engraftment of DLA-haploidentical marrow with ex vivo expanded, retrovirally transduced cytotoxic T lymphocytes Blood, December 1, 2001; 98(12): 3447 - 3455. [Abstract] [Full Text] [PDF] J. L. Cohen, O. Boyer, and D. Klatzmann Suicide gene therapy of graft-versus-host disease: immune reconstitution with transplanted mature T cells Blood, October 1, 2001; 98(7): 2071 - 2076. [Abstract] [Full Text] [PDF]

	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020