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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fry, T. J. Articles by Mackall, C. L. Search for Related Content PubMed PubMed Citation Articles by Fry, T. J. Articles by Mackall, C. L. Related Collections Hematopoiesis and Stem Cells Immunobiology Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 May 2001, Vol. 97, No. 10, pp. 2983-2990 CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS A potential role for interleukin-7 in T-cell homeostasis Terry J. Fry, Elizabeth Connick, Judith Falloon, Michael M. Lederman, David J. Liewehr, John Spritzler, Seth M. Steinberg, Lauren V. Wood, Robert Yarchoan, Judy Zuckerman, Alan Landay, and Crystal L. Mackall From the Pediatric Oncology Branch, Biostatistics and Data Management Section, and HIV and AIDS Malignancy Branch of the National Cancer Institute; and National Institute of Allergy and Infectious Diseases; all of the National Institutes of Health, Bethesda, MD; University of Colorado Health Sciences Center, Denver CO; Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, OH; Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA; and Rush Medical College, Chicago IL. Interleukin (IL)-7 is known to up-regulate thymopoietic pathways of T-cell regeneration. Recent work also has shown it to potently enhance thymic-independent peripheral expansion and to restore immunocompetence in athymic T-cell-depleted hosts. We hypothesized that endogenous IL-7 could contribute to the restoration of T-cell homeostasis following T-cell depletion. To analyze this, we evaluated circulating IL-7 levels and lymphocyte subsets in multiple clinical cohorts with T-cell depletion of varying etiologies. In pediatric (n = 41) and adult (n = 51) human immunodeficiency virus-infected CD4-depleted patients, there were strong inverse correlations between IL-7 levels and CD4 counts (r = 0.77, P < .0001, and r = 0.68, P < .0001). Declines in IL-7 were temporally correlated with recovery of CD4 counts. Similar patterns were observed in CD4-depleted patients receiving cancer chemotherapy (r = 0.65, P = .009). Therefore, in 2 disparate clinical scenarios involving CD4 depletion, IL-7 levels dynamically respond to changes in CD4 T-cell number, making this cytokine uniquely suited as a candidate regulator of T-cell homeostasis. Furthermore, in patients with idiopathic CD4 lymphopenia, a much weaker relationship between IL-7 levels and peripheral blood CD4 counts was observed, suggesting that an impaired IL-7 response to CD4 depletion may contribute to the impaired lymphocyte homeostasis observed in this population. In light of the known effects of IL-7 on T-cell regeneration, we postulate that increased availability of IL-7 could play a critical role in restoring T-cell homeostasis following T-cell depletion. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. Cui, H. Zhang, J. Meadors, R. Poon, M. Guimond, and C. L. Mackall Harnessing the physiology of lymphopenia to support adoptive immunotherapy in lymphoreplete hosts Blood, October 29, 2009; 114(18): 3831 - 3840. [Abstract] [Full Text] [PDF] S. Beq, S. Rozlan, D. Gautier, R. Parker, V. Mersseman, C. Schilte, B. Assouline, I. 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