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Related Collections Immunobiology Apoptosis Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 May 2001, Vol. 97, No. 10, pp. 3161-3170 IMMUNOBIOLOGY Increases in circulating and lymphoid tissue interleukin-10 in autoimmune lymphoproliferative syndrome are associated with disease expression Uri Lopatin, Xu Yao, Richard K. Williams, Jack J. H. Bleesing, Janet K. Dale, David Wong, Julie Teruya-Feldstein, Scott Fritz, Matthew R. Morrow, Ivan Fuss, Michael C. Sneller, Mark Raffeld, Thomas A. Fleisher, Jennifer M. Puck, Warren Strober, Elaine S. Jaffe, and Stephen E. Straus From the Laboratory of Clinical Investigation, Clinical Research Training Program, and Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Laboratory of Pathology, National Cancer Institute, National Human Genome Research Institute, and Clinical Pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland; and SAIC, Inc, Frederick, Maryland. Autoimmune lymphoproliferative syndrome (ALPS) is an inherited disorder in which genetic defects in proteins that mediate lymphocyte apoptosis, most often Fas, are associated with enlargement of lymph nodes and the spleen and a variety of autoimmune manifestations. Some patients with ALPS have relatives with these same apoptotic defects, however, who are clinically well. This study showed that the circulating levels of interleukin 10 (IL-10) were significantly higher (P < .001) in 21 patients with ALPS than in healthy controls. Moreover, the peripheral blood mononuclear cells (PBMCs) and lymphoid tissues of these patients with ALPS contained significantly higher levels of IL-10 messenger RNA (mRNA; P < .001 and P < .01, respectively). By fractionating PBMC populations, disproportionately high concentrations of IL-10 mRNA were found in the CD4CD8 T-cell population, expansion of which is virtually pathognomonic for ALPS. Immunohistochemical staining showed intense IL-10 protein signals in lymph node regions known to contain CD4CD8 T cells. Nonetheless, in vitro studies showed no influence of IL-10 on the survival of CD4CD8 T cells. Overexpression of IL-10 in patients with inherited apoptotic defects is strongly associated with the overt manifestations of ALPS. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Magerus-Chatinet, M.-C. Stolzenberg, M. S. Loffredo, B. Neven, C. 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