|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 June 2001, Vol. 97, No. 11, pp. 3458-3465
IMMUNOBIOLOGY
Allogeneic bone marrow cells that facilitate complete chimerism
and eliminate tumor cells express both CD8 and T-cell
antigen receptor- 
Fengshuo Lan,
Defu Zeng,
Philip Huie,
John P. Higgins, and
Samuel Strober
From the Department of Medicine, Division of Immunology
and Rheumatology, and the Department of Pathology, Stanford University
School of Medicine, Stanford, CA.
Nonmyeloablative host conditioning regimens have been used in
clinical allogeneic bone marrow and hematopoietic progenitor transplantation to effectively treat lymphohematopoietic tumors and
reduce early toxicity. However, severe graft-versus-host disease (GVHD)
remains a major problem. The goal of the current study was to determine
whether specific subsets of cells in allogeneic bone marrow transplants
can effectively treat the BCL1 B-cell lymphoma in
nonmyeloablated BALB/c mouse hosts given a single dose of sublethal
(450 cGy) total body irradiation, without inducing severe GVHD. The
experimental results show that high doses of whole bone marrow cells
from major histocompatiblity complex (MHC)-mismatched donors eliminate
both normal and malignant host-type lymphohematopoietic cells without
causing injury to nonlymphohematopoietic host tissues. The
CD8+T-cell antigen receptor-  +
(TCR+) T cells within the marrow transplants
mediated the killing of the tumor cells via both perforin- and
FasL-dependent pathways. Cells present in marrow transplants from
either CD8 / or TCR/ donors failed to
eliminate malignant and normal host lymphohematopoietic cells. Addition
of small numbers of blood mononuclear cells to the marrow inoculum
caused lethal GVHD. Thus, the resident allogeneic bone marrow
CD8+ TCR+ T cells had the unique capacity
to eliminate the host lymphohematopoietic cells without
nonlymphohematopoietic tissue injury.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. B. Pillai, T. I. George, S. Dutt, P. Teo, and S. Strober
Host NKT Cells Can Prevent Graft-versus-Host Disease and Permit Graft Antitumor Activity after Bone Marrow Transplantation
J. Immunol.,
May 15, 2007;
178(10):
6242 - 6251.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Zhang, J. Lou, N. Li, I. Todorov, C.-L. Lin, Y.-A. Cao, C. H. Contag, F. Kandeel, S. Forman, and D. Zeng
Donor CD8+ T Cells Mediate Graft-versus-Leukemia Activity without Clinical Signs of Graft-versus-Host Disease in Recipients Conditioned with Anti-CD3 Monoclonal Antibody
J. Immunol.,
January 15, 2007;
178(2):
838 - 850.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. M. Cao, J. A. Shizuru, R. M. Wong, K. Sheehan, G. G. Laport, K. E. Stockerl-Goldstein, L. J. Johnston, M. J. Stuart, F. C. Grumet, R. S. Negrin, et al.
Engraftment and survival following reduced-intensity allogeneic peripheral blood hematopoietic cell transplantation is affected by CD8+ T-cell dose
Blood,
March 15, 2005;
105(6):
2300 - 2306.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Ermann, P. Hoffmann, M. Edinger, S. Dutt, F. G. Blankenberg, J. P. Higgins, R. S. Negrin, C. G. Fathman, and S. Strober
Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD
Blood,
March 1, 2005;
105(5):
2220 - 2226.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. L. Colson, K. Christopher, J. Glickman, K. N. Taylor, R. Wright, and D. L. Perkins
Absence of clinical GVHD and the in vivo induction of regulatory T cells after transplantation of facilitating cells
Blood,
December 1, 2004;
104(12):
3829 - 3835.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Hoffmann, J. Ermann, M. Edinger, C. G. Fathman, and S. Strober
Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation
J. Exp. Med.,
August 5, 2002;
196(3):
389 - 399.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Zeng, P. Hoffmann, F. Lan, P. Huie, J. Higgins, and S. Strober
Unique patterns of surface receptors, cytokine secretion, and immune functions distinguish T cells in the bone marrow from those in the periphery: impact on allogeneic bone marrow transplantation
Blood,
February 15, 2002;
99(4):
1449 - 1457.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Lan, D. Zeng, M. Higuchi, P. Huie, J. P. Higgins, and S. Strober
Predominance of NK1.1+TCR{alpha}{beta}+ or DX5+TCR{alpha}{beta}+ T Cells in Mice Conditioned with Fractionated Lymphoid Irradiation Protects Against Graft-Versus-Host Disease: "Natural Suppressor" Cells
J. Immunol.,
August 15, 2001;
167(4):
2087 - 2096.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
