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Related Collections Immunobiology Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 June 2001, Vol. 97, No. 11, pp. 3498-3504 IMMUNOBIOLOGY Functional soluble CD100/Sema4D released from activated lymphocytes: possible role in normal and pathologic immune responses Xiaosong Wang, Atsushi Kumanogoh, Chie Watanabe, Wei Shi, Kanji Yoshida, and Hitoshi Kikutani From the Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, Japan. CD100/Sema4D is a 150-kd transmembrane protein that belongs to the semaphorin family. The interaction of CD100 with CD72 is critical for the immune system. In CD100-deficient mice, the production of specific antibodies against T-cell-dependent antigens is severely impaired, but not against T-cell-independent antigens. Here, a functional soluble CD100 protein (sCD100) released from activated lymphocytes is reported. sCD100 was detected in culture supernatants of activated lymphocytes. Either affinity-purified from supernatants of activated T-cells, or produced as a recombinant sCD100 protein consisting of the extracellular region of the mouse CD100 fused to the human IgG1 Fc (CD100-Fc), sCD100 significantly enhanced CD40-induced B-cell responses. Furthermore, sCD100 was detected either in sera of mice immunized with T-cell-dependent antigens, or in sera of MRL/lpr mice, but not in sera of mice immunized with T-cell-independent antigens. A significant correlation was observed between the level of sCD100 and the titer of autoantibodies in the serum of MRL/lpr mice. This study's findings suggest a potential role for sCD100 in immune responses, including production of antibody, and autoimmune diseases. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. R. Basile, J. Gavard, and J. S. Gutkind Plexin-B1 Utilizes RhoA and Rho Kinase to Promote the Integrin-dependent Activation of Akt and ERK and Endothelial Cell Motility J. Biol. Chem., November 30, 2007; 282(48): 34888 - 34895. [Abstract] [Full Text] [PDF] L. Zhu, W. Bergmeier, J. Wu, H. Jiang, T. J. Stalker, M. Cieslak, R. Fan, L. Boumsell, A. Kumanogoh, H. Kikutani, et al. Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury PNAS, January 30, 2007; 104(5): 1621 - 1626. [Abstract] [Full Text] [PDF] J. R. Basile, R. M. Castilho, V. P. Williams, and J. S. 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	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020