|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 June 2001, Vol. 97, No. 11, pp. 3574-3580
NEOPLASIA
High frequency of immunophenotype changes in acute myeloid
leukemia at relapse: implications for residual disease
detection (Cancer and Leukemia Group B Study 8361)
Maria R. Baer,
Carleton C. Stewart,
Richard K. Dodge,
Gail Leget,
Norbert Sulé,
Krzysztof Mrózek,
Charles A. Schiffer,
Bayard L. Powell,
Jonathan E. Kolitz,
Joseph O. Moore,
Richard M. Stone,
Frederick R. Davey,
Andrew J. Carroll,
Richard A. Larson, and
Clara D. Bloomfield
From the Roswell Park Cancer Institute, Buffalo, New
York; CALGB Statistical Center, Durham, North Carolina; Southeastern
Cancer Center, Lumberton, North Carolina; The Ohio State University
Medical Center, Columbus, Ohio; Wayne State University School of
Medicine, Detroit, Michigan; Wake Forest University School of Medicine,
Winston-Salem, North Carolina; North Shore University Hospital,
Manhasset, New York; Duke University Medical Center, Durham,
North Carolina; Dana-Farber Cancer Institute, Boston,
Massachusetts; State University of New York Upstate Medical
University, Syracuse, New York; University of Alabama at Birmingham;
University of Chicago Medical Center, Chicago, Illinois.
Multiparameter flow cytometry (MFC) has the potential to allow for
sensitive and specific monitoring of residual disease (RD) in acute
myeloid leukemia (AML). The use of MFC for RD monitoring assumes that
AML cells identified by their immunophenotype at diagnosis can be
detected during remission and at relapse. AML cells from 136 patients
were immunophenotyped by MFC at diagnosis and at first relapse using 9 panels of 3 monoclonal antibodies. Immunophenotype changes
occurred in 124 patients (91%); they consisted of gains or losses of
discrete leukemia cell populations resolved by MFC (42 patients) and
gains or losses of antigens on leukemia cell populations present at
both time points (108 patients). Antigen expression defining unusual
phenotypes changed frequently: CD13, CD33, and CD34, absent at
diagnosis in 3, 33, and 47 cases, respectively, were gained at relapse
in 2 (67%), 15 (45%), and 17 (36%); CD56, CD19, and CD14, present at
diagnosis in 5, 16, and 20 cases, were lost at relapse in 2 (40%), 6 (38%), and 8 (40%). Leukemia cell gates created in pretreatment
samples using each 3-antibody panel allowed identification of relapse
AML cells in only 68% to 91% of cases, but use of 8 3-antibody
panels, which included antibodies to a total of 16 antigens, allowed
identification of relapse AML cells in all cases. Thus, the
immunophenotype of AML cells is markedly unstable; nevertheless,
despite this instability, MFC has the potential to identify RD in
AML if multiple antibody panels are used at all time points.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
D. M. P. Cronin, T. I. George, and U. N. Sundram
An Updated Approach to the Diagnosis of Myeloid Leukemia Cutis
Am J Clin Pathol,
July 1, 2009;
132(1):
101 - 110.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Maurillo, F. Buccisano, M. I. Del Principe, G. Del Poeta, A. Spagnoli, P. Panetta, E. Ammatuna, B. Neri, L. Ottaviani, C. Sarlo, et al.
Toward Optimization of Postremission Therapy for Residual Disease-Positive Patients With Acute Myeloid Leukemia
J. Clin. Oncol.,
October 20, 2008;
26(30):
4944 - 4951.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Colado, S. Alvarez-Fernandez, P. Maiso, J. Martin-Sanchez, M. B. Vidriales, M. Garayoa, E. M. Ocio, J. C. Montero, A. Pandiella, and J. F. San Miguel
The effect of the proteasome inhibitor bortezomib on acute myeloid leukemia cells and drug resistance associated with the CD34+ immature phenotype
Haematologica,
January 1, 2008;
93(1):
57 - 66.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Maurillo, F. Buccisano, A. Spagnoli, G. Del Poeta, P. Panetta, B. Neri, M. I. Del Principe, C. Mazzone, M. I. Consalvo, A. Tamburini, et al.
Monitoring of minimal residual disease in adult acute myeloid leukemia using peripheral blood as an alternative source to bone marrow
Haematologica,
May 1, 2007;
92(5):
605 - 611.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Langebrake, U. Creutzig, M. Dworzak, O. Hrusak, E. Mejstrikova, F. Griesinger, M. Zimmermann, and D. Reinhardt
Residual Disease Monitoring in Childhood Acute Myeloid Leukemia by Multiparameter Flow Cytometry: The MRD-AML-BFM Study Group
J. Clin. Oncol.,
August 1, 2006;
24(22):
3686 - 3692.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Steinbach, A. Schramm, A. Eggert, M. Onda, K. Dawczynski, A. Rump, I. Pastan, S. Wittig, N. Pfaffendorf, A. Voigt, et al.
Identification of a Set of Seven Genes for the Monitoring of Minimal Residual Disease in Pediatric Acute Myeloid Leukemia
Clin. Cancer Res.,
April 15, 2006;
12(8):
2434 - 2441.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Feller, M. A. van der Pol, T. Waaijman, G. W.D. Weijers, G. Westra, G. J. Ossenkoppele, and G. J. Schuurhuis
Immunologic Purging of Autologous Peripheral Blood Stem Cell Products Based on CD34 and CD133 Expression Can Be Effectively and Safely Applied in Half of the Acute Myeloid Leukemia Patients
Clin. Cancer Res.,
July 1, 2005;
11(13):
4793 - 4801.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. B. H. Bakker, S. van den Oudenrijn, A. Q. Bakker, N. Feller, M. van Meijer, J. A. Bia, M. A. C. Jongeneelen, T. J. Visser, N. Bijl, C. A. W. Geuijen, et al.
C-Type Lectin-Like Molecule-1: A Novel Myeloid Cell Surface Marker Associated with Acute Myeloid Leukemia
Cancer Res.,
November 15, 2004;
64(22):
8443 - 8450.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Marcucci, K. Mrozek, A. S. Ruppert, K. J. Archer, M. J. Pettenati, N. A. Heerema, A. J. Carroll, P. R.K. Koduru, J. E. Kolitz, L. J. Sterling, et al.
Abnormal Cytogenetics at Date of Morphologic Complete Remission Predicts Short Overall and Disease-Free Survival, and Higher Relapse Rate in Adult Acute Myeloid Leukemia: Results From Cancer and Leukemia Group B Study 8461
J. Clin. Oncol.,
June 15, 2004;
22(12):
2410 - 2418.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Sekeres, B. Peterson, R. K. Dodge, R. J. Mayer, J. O. Moore, E. J. Lee, J. Kolitz, M. R. Baer, C. A. Schiffer, A. J. Carroll, et al.
Differences in prognostic factors and outcomes in African Americans and whites with acute myeloid leukemia
Blood,
June 1, 2004;
103(11):
4036 - 4042.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. D. Cheson, J. M. Bennett, K. J. Kopecky, T. Buchner, C. L. Willman, E. H. Estey, C. A. Schiffer, H. Doehner, M. S. Tallman, T. A. Lister, et al.
Revised Recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia
J. Clin. Oncol.,
December 15, 2003;
21(24):
4642 - 4649.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Tallman, J. W. Andersen, C. A. Schiffer, F. R. Appelbaum, J. H. Feusner, W. G. Woods, A. Ogden, H. Weinstein, L. Shepherd, C. Willman, et al.
All-trans retinoic acid in acute promyelocytic leukemia: long-term outcome and prognostic factor analysis from the North American Intergroup protocol
Blood,
December 15, 2002;
100(13):
4298 - 4302.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. van der Kolk, E. Vellenga, G. L. Scheffer, M. Muller, S. E. Bates, R. J. Scheper, and E. G. E. de Vries
Expression and activity of breast cancer resistance protein (BCRP) in de novo and relapsed acute myeloid leukemia
Blood,
May 15, 2002;
99(10):
3763 - 3770.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
