|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 June 2001, Vol. 97, No. 11, pp. 3628-3632
RED CELLS
Five years of experience with hydroxyurea in children and young
adults with sickle cell disease
Alina Ferster,
Parvine Tahriri,
Christiane Vermylen,
Geneviève Sturbois,
Francis Corazza,
Pierre Fondu,
Christine Devalck,
Marie F. Dresse,
Walter Feremans,
Kathleen Hunninck,
Michele Toppet,
Pierre Philippet,
Chris Van
Geet, and
Eric Sariban
From the Hemato-Oncology Unit, Hôpital
Universitaire des Enfants Reine Fabiola; the Department of Pediatric
Hematology, Cliniques Universitaires St Luc; and the Department of
Hematology, Hôpital Erasme, Brussels, Belgium; Service de
Pédiatrie, Clinique de l'Espérance, Montegnée,
Belgium; Service de Pédiatrie, Hôpital de la
Citadelle, Liège, Belgium; Kliniek voor Kinderziekten,
Universitair Ziekenhuis, Ghent, Belgium; and UZ Gasthuisberg, Leuven,
Belgium.
The short-term beneficial effect of hydroxyurea (HU) in sickle cell
disease (SCD) has been proven by randomized studies in children and
adults. The Belgian registry of HU-treated SCD patients was created to
evaluate its long-term efficacy and toxicity. The median follow-up of
the 93 patients registered is 3.5 years; clinical and laboratory data
have been obtained for 82 patients at 1 year, 61 at 2 years, 44 at 3 years, 33 at 4 years, and 22 after 5 years. On HU, the number of
hospitalizations and days hospitalized dropped significantly. Analysis
of the 22 patients with a minimum of 5 years of follow-up confirm a
significant difference in the number of hospitalizations
(P = .0002) and days in the hospital
(P < .01), throughout the treatment when compared to
prior to HU therapy. The probabilities of not experiencing any event or
any vaso-occlusive crisis requiring hospitalization during the 5 years
of treatment were, respectively, 47% and 55%. On HU, the rate per 100 patient-years of severe events was estimated to be 3.5% for acute
chest syndrome, 1.2% for aplastic crisis, 0.4% for splenic
sequestration; it was 0% for the 9 patients with a history of stroke
or transient ischemic attack followed for an average of 4 years. No
important adverse effect occurred. Long-term chronic treatment with HU
for patients with SCD appears feasible, effective, and devoid of any
major toxicity; in patients with a history of stroke, HU may be a valid alternative to chronic transfusion support.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
Related Letter in Blood Online:
-
A patient on hydroxyurea for sickle cell disease who developed an opportunistic infection
- Pramila Venigalla, Bharat Motwani, Anitha Nallari, Sandra Allen, Manoj Agarwal, Manuel Alva, Maxwell Westerman, and Lawrence Feldman
Blood 2002 100: 363-364.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
J. J. Strouse, S. Lanzkron, M. C. Beach, C. Haywood, H. Park, C. Witkop, R. F. Wilson, E. B. Bass, and J. B. Segal
Hydroxyurea for Sickle Cell Disease: A Systematic Review for Efficacy and Toxicity in Children
Pediatrics,
December 1, 2008;
122(6):
1332 - 1342.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Lanzkron, J. J. Strouse, R. Wilson, M. C. Beach, C. Haywood, H. Park, C. Witkop, E. B. Bass, and J. B. Segal
Systematic Review: Hydroxyurea for the Treatment of Adults with Sickle Cell Disease
Ann Intern Med,
June 17, 2008;
148(12):
939 - 955.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. S. Platt
Prevention and Management of Stroke in Sickle Cell Anemia
Hematology,
January 1, 2006;
2006(1):
54 - 57.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. S. Hankins, R. E. Ware, Z. R. Rogers, L. W. Wynn, P. A. Lane, J. P. Scott, and W. C. Wang
Long-term hydroxyurea therapy for infants with sickle cell anemia: the HUSOFT extension study
Blood,
October 1, 2005;
106(7):
2269 - 2275.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Gulbis, D. Haberman, D. Dufour, C. Christophe, C. Vermylen, F. Kagambega, F. Corazza, C. Devalck, M.-F. Dresse, K. Hunninck, et al.
Hydroxyurea for sickle cell disease in children and for prevention of cerebrovascular events: the Belgian experience
Blood,
April 1, 2005;
105(7):
2685 - 2690.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M de Montalembert, C Maunoury, P Acar, V Brousse, D Sidi, and G Lenoir
Myocardial ischaemia in children with sickle cell disease
Arch. Dis. Child.,
April 1, 2004;
89(4):
359 - 362.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Zimmerman, W. H. Schultz, J. S. Davis, C. V. Pickens, N. A. Mortier, T. A. Howard, and R. E. Ware
Sustained long-term hematologic efficacy of hydroxyurea at maximum tolerated dose in children with sickle cell disease
Blood,
March 15, 2004;
103(6):
2039 - 2045.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. E. Wilson, L. Krishnamurti, and D. Kamat
Management of Sickle Cell Disease in Primary Care
Clinical Pediatrics,
November 1, 2003;
42(9):
753 - 761.
[PDF]
|
|
|
|
|
|
|
M. H. Steinberg, F. Barton, O. Castro, C. H. Pegelow, S. K. Ballas, A. Kutlar, E. Orringer, R. Bellevue, N. Olivieri, J. Eckman, et al.
Effect of Hydroxyurea on Mortality and Morbidity in Adult Sickle Cell Anemia: Risks and Benefits Up to 9 Years of Treatment
JAMA,
April 2, 2003;
289(13):
1645 - 1651.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Venigalla, B. Motwani, A. Nallari, S. Allen, M. Agarwal, M. Alva, M. Westerman, and L. Feldman
A patient on hydroxyurea for sickle cell disease who developed an opportunistic infection
Blood,
June 17, 2002;
100(1):
363 - 364.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. de Montalembert and S. C. Davies
Is hydroxyurea leukemogenic in children with sickle cell disease?
Blood,
November 1, 2001;
98(9):
2878 - 2879.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Adams, K. Ohene-Frempong, and W. Wang
Sickle Cell and the Brain
Hematology,
January 1, 2001;
2001(1):
31 - 46.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. S. Hankins, R. E. Ware, Z. R. Rogers, L. W. Wynn, P. A. Lane, J. P. Scott, and W. C. Wang
Long-term hydroxyurea therapy for infants with sickle cell anemia: the HUSOFT extension study
Blood,
October 1, 2005;
106(7):
2269 - 2275.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
