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Related Collections Neoplasia Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 June 2001, Vol. 97, No. 11, pp. 3648-3650 BRIEF REPORT Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon- Manuel Schmidt, Andreas Hochhaus, Andreas Nitsche, Rüdiger Hehlmann, and Andreas Neubauer From the Klinikum der Philipps-Universität Marburg, Zentrum Innere Medizin, Abteilung Hämatologie/Onkologie/Immunologie, Marburg, Germany; III. Medizinische Universitätsklinik, Klinikum Mannheim der Universität Heidelberg, Germany; and Klinik für Innere Medizin m.S. Hamatologie und Onkologie, Charité-Campus Virchow Klinikum, Humboldt Universität, Berlin, Germany. Recently, it was shown that interferon consensus sequence binding protein (ICSBP), a member of the interferon regulatory factor (IRF) family, has a potential role in chronic myeloid leukemia (CML). Deletion of ICSBP gene in mice leads to a CML-like syndrome and samples from CML patients exhibited impaired ICSBP expression. The present study found that ICSBP expression correlated with risk features determined by Sokal score in untreated CML (P = .007 for high versus low risk). In addition, analyzing ICSBP expression during interferon- (IFN-) therapy in "good" (n = 27) versus "poor" (n = 15) cytogenetic responders, high ICSBP levels were only observed in "good" responders (P = .0002). Together, these data suggest that ICSBP levels are related to initial presentation of CML and the therapeutic response of CML to IFN-, indicating an important role of ICSBP in CML. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. Saberwal, E. Horvath, L. Hu, C. Zhu, E. Hjort, and E. A. Eklund The Interferon Consensus Sequence Binding Protein (ICSBP/IRF8) Activates Transcription of the FANCF Gene during Myeloid Differentiation J. Biol. Chem., November 27, 2009; 284(48): 33242 - 33254. [Abstract] [Full Text] [PDF] J. Koenigsmann, C. Rudolph, S. Sander, O. Kershaw, A. D. Gruber, L. Bullinger, B. Schlegelberger, and D. Carstanjen Nf1 haploinsufficiency and Icsbp deficiency synergize in the development of leukemias Blood, May 7, 2009; 113(19): 4690 - 4701. [Abstract] [Full Text] [PDF] J. Acquaviva, X. Chen, and R. 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	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020