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Blood, 15 June 2001, Vol. 97, No. 12, pp. 3966-3971
RED CELLS
Inhibition of Plasmodium yoelii blood-stage malaria by
interferon  through the inhibition of the production of its target
cell, the reticulocyte
Ana Margarida Vigário,
Elodie Belnoue,
Ana Cumano,
Myriam Marussig,
François Miltgen,
Irene Landau,
Dominique Mazier,
Ion Gresser, and
Laurent Rénia
From INSERM Unité 445, ICGM, Université
René Descartes, Hôpital Cochin; Unité du
Dévelopment des Lymphocytes, Institut Pasteur; INSERM Unité
511, Hôpital Pitié-Salpêtrière; and Museum
National d'Histoire Naturelle, Paris, France; and Laboratoire
d'Oncologie Virale (UPR 9045), Institut de Recherches sur le Cancer,
Villejuif, France.
The effect of a recombinant hybrid human interferon  (IFN-)
(which cross-reacts with murine cells) on C57BL/6 mice infected with Plasmodium yoelii sporozoites or parasitized
erythrocytes was determined. IFN- did not inhibit the
development of the parasite in the liver, but it did reduce the
blood parasite load and the hepatosplenomegaly induced by the infection
in mice injected with blood-stage parasites. The extent of anemia in
IFN--treated and control mice was similar, despite the lower
parasite load in the IFN--treated mice. The reduced blood parasite
load in IFN--treated mice was associated with reduced
erythropoiesis and reticulocytosis. As reticulocytes are the preferred
target cells for the strain of P yoelii used (P
yoelii yoelii 265 BY), it was postulated that the
inhibition of reticulocytosis in IFN--treated mice was causally related to the observed decreased blood parasite load. This was supported by the finding that IFN- inhibited a different strain of
P yoelii (17X clone A), which also displays a tropism for
reticulocytes, but not a line of Plasmodium vinckei
petteri, which infects only mature red blood cells. As
human malaria species also display different tropism for reticulocytes,
these findings could be relevant for people coinfected with
multiple Plasmodium species or strains or
coinfected with Plasmodium and virus.
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