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Blood, 15 June 2001, Vol. 97, No. 12, pp. 3984-3988
RED CELLS
Unavailability of CD147 leads to selective erythrocyte trapping
in the spleen
Isabelle Coste,
Jean-François Gauchat,
Anne Wilson,
Shozo Izui,
Pascale Jeannin,
Yves Delneste,
H.
Robson MacDonald,
Jean-Yves Bonnefoy, and
Toufic Renno
From the Centre d'Immunologie Pierre Fabre,
Saint-Julien en Genevois, France; the Ludwig Institute Cancer Research,
Lausanne Branch, University of Lausanne, Lausanne, Switzerland; and the
Department of Pathology, University of Geneva, Geneva, Switzerland.
Adhesive interactions with stromal cells and the extracellular
matrix are essential for the differentiation and migration of
hematopoietic progenitors. In the erythrocytic lineage, a number of
adhesion molecules are expressed in the developing erythrocytes and are
thought to play a role in the homing and maturation of erythrocytic
progenitors. However, many of these molecules are lost during the final
developmental stages leading to mature erythrocytes. One of the
adhesion molecules that remains expressed in mature, circulating
erythrocytes is CD147. This study shows that blockade of this molecule
on the cell surface by treatment with F(ab')2 fragments of
anti-CD147 monoclonal antibody disrupts the circulation of
erythrocytes, leading to their selective trapping in the spleen. Consequently, mice develop an anemia, and de novo,
erythropoietin-mediated erythropoiesis in the spleen. In contrast,
these changes were not seen in mice similarly treated with another
antierythrocyte monoclonal antibody with a different specificity. These
results suggest that the CD147 expressed on erythrocytes likely plays a
critical role in the recirculation of mature erythrocytes from the
spleen into the general circulation.
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