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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Asazuma, N. Articles by Watson, S. P. Search for Related Content PubMed PubMed Citation Articles by Asazuma, N. Articles by Watson, S. P. Related Collections Hemostasis, Thrombosis, and Vascular Biology Signal Transduction Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 June 2001, Vol. 97, No. 12, pp. 3989-3991 BRIEF REPORT The snake venom toxin alboaggregin-A activates glycoprotein VI Naoki Asazuma, Stuart J. Marshall, Oscar Berlanga, Daniel Snell, Alastair W. Poole, Michael C. Berndt, Robert K. Andrews, and Steve P. Watson From the Department of Pharmacology, University of Oxford, and the Department of Pharmacology, University of Bristol, School of Medical Sciences, United Kingdom; and the Baker Medical Research Institute, Melbourne, Australia. The glycoprotein (GP)-Ib-IX-V receptor complex has recently been reported to signal through a pathway similar to that used by the collagen receptor GPVI, with a critical role described for the Fc receptor -chain. The evidence for this was based in part on studies with the GPIb-selective snake venom toxin, alboaggregin-A. In the present study, it is reported that alboaggregin-A has activity at the collagen receptor GPVI in addition to GPIb, and evidence is provided that this contributes to protein tyrosine phosphorylation, shape change, and GPIIb-IIIa-dependent aggregation. This may explain why responses to alboaggregin-A are distinct from those to von Willebrand factor- ristocetin. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. Suzuki-Inoue, G. L. J. Fuller, A. Garcia, J. A. Eble, S. Pohlmann, O. Inoue, T. K. Gartner, S. C. Hughan, A. C. Pearce, G. D. Laing, et al. A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2 Blood, January 15, 2006; 107(2): 542 - 549. [Abstract] [Full Text] [PDF] G. Pula, D. Crosby, J. Baker, and A. W. Poole Functional Interaction of Protein Kinase C{alpha} with the Tyrosine Kinases Syk and Src in Human Platelets J. Biol. Chem., February 25, 2005; 280(8): 7194 - 7205. [Abstract] [Full Text] [PDF] B. Nieswandt and S. P. Watson Platelet-collagen interaction: is GPVI the central receptor? Blood, July 15, 2003; 102(2): 449 - 461. [Abstract] [Full Text] [PDF] X.-Y. Du, J. M. Clemetson, A. Navdaev, E. M. Magnenat, T. N. C. Wells, and K. J. Clemetson Ophioluxin, a Convulxin-like C-type Lectin from Ophiophagus hannah (King Cobra) Is a Powerful Platelet Activator via Glycoprotein VI J. Biol. Chem., September 13, 2002; 277(38): 35124 - 35132. [Abstract] [Full Text] [PDF] R. K. Andrews, K. Suzuki-Inoue, Y. Shen, D. Tulasne, S. P. Watson, and M. C. Berndt Interaction of calmodulin with the cytoplasmic domain of platelet glycoprotein VI Blood, May 13, 2002; 99(11): 4219 - 4221. [Abstract] [Full Text] [PDF] D. Crosby and A. W. Poole Interaction of Bruton's Tyrosine Kinase and Protein Kinase Ctheta in Platelets. CROSS-TALK BETWEEN TYROSINE AND SERINE/THREONINE KINASES J. Biol. Chem., March 15, 2002; 277(12): 9958 - 9965. [Abstract] [Full Text] [PDF] R. K. Andrews, E. E. Gardiner, N. Asazuma, O. Berlanga, D. Tulasne, B. Nieswandt, A. I. Smith, M. C. Berndt, and S. P. Watson A Novel Viper Venom Metalloproteinase, Alborhagin, Is an Agonist at the Platelet Collagen Receptor GPVI J. Biol. Chem., July 20, 2001; 276(30): 28092 - 28097. [Abstract] [Full Text] [PDF]

	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020