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Blood, 1 February 2001, Vol. 97, No. 3, pp. 601-607
CHEMOKINES
Interferon-inducible protein 10, monokine induced by interferon
gamma, and interferon-inducible T-cell alpha chemoattractant are
produced by thymic epithelial cells and attract T-cell receptor (TCR)
  +CD8+ single-positive T cells,
TCR  + T cells, and natural killer-type cells in human
thymus
Paola Romagnani,
Francesco Annunziato,
Elena Lazzeri,
Lorenzo Cosmi,
Chiara Beltrame,
Laura Lasagni,
Grazia Galli,
Michela Francalanci,
Roberto Manetti,
Fabio Marra,
Vittorio Vanini,
Enrico Maggi, and
Sergio Romagnani
From the Department of Physiopathology, Endocrinology
Unit, and the Department of Internal Medicine, University of
Florence, Florence, Italy, and the Apuanic Pediatric Hospital,
Massa-Carrara, Italy.
Strong reactivity for interferon-inducible protein 10 (IP-10),
monokine induced by interferon gamma (Mig), and interferon-inducible T-cell alpha chemoattractant (I-TAC) was found in epithelial cells mainly localized to the medulla of postnatal human thymus. The CXC
chemokine receptor common to the 3 chemokines (CXCR3) was also
preferentially expressed in medullary areas of the same thymuses and appeared to be a property of 4 distinct populations:
CD3+T-cell receptor (TCR)
  +CD8+ single-positive (SP) T cells,
TCR  + T cells, natural killer (NK)-type cells,
and a small subset of CD3+(low)CD4+CD8+TCR+
double-positive (DP) T cells. IP-10, Mig, and I-TAC showed
chemoattractant activity for TCR+CD8+ SP
T cells, TCR+ T cells, and NK-type cells, suggesting
their role in the migration of different subsets of mature thymocytes
during human thymus lymphopoiesis.
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