|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 February 2001, Vol. 97, No. 3, pp. 692-699
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY
Oncostatin M promotes biphasic tissue factor expression in smooth
muscle cells: evidence for Erk-1/2 activation
Toshiya Nishibe,
Graham Parry,
Atsushi Ishida,
Salim Aziz,
Jacqueline Murray,
Yatin Patel,
Salman Rahman,
Kurt Strand,
Keiko Saito,
Yuji Saito,
William P. Hammond,
Geoffrey F. Savidge,
Nigel Mackman, and
Errol S. Wijelath
From the Department of Molecular Biology, The Hope
Heart Institute and Providence Medical Center, Seattle, WA;
Departments of Immunology and Vascular Biology, The Scripps
Research Institute, La Jolla, CA; Division of Cardiothoracic
Surgery, Health Science Center, University of Colorado, Denver, CO;
Coagulation Research Laboratory, Haemophilia Reference Centre,
GKT Medical School, St. Thomas Hospital, London, United Kingdom.
Tissue factor (TF), a transmembrane glycoprotein, initiates the
extrinsic coagulation cascade. TF is known to play a major role in
mediating thrombosis and thrombotic episodes associated with the
progression of atherosclerosis. Macrophages at inflammatory sites, such
as atherosclerotic lesions, release numerous cytokines that are capable
of modulating TF expression. This study examined the role of oncostatin
M (OSM), a macrophage/ T-lymphocyte-restricted cytokine, in the
expression of TF in vascular smooth muscle cells (SMCs). It is reported
here that OSM stimulated a biphasic and sustained pattern of TF
messenger RNA (mRNA). The effect of OSM on TF mRNA expression was
regulated at the transcriptional level as determined by nuclear
run-offs and transient transfection of a TF promoter-reporter gene
construct. OSM-induced TF expression was regulated primarily by the
transcription factor NF- B. Activation of NF-B by OSM did not
require IB- degradation. Inhibition of MEK activity by U0126
prevented OSM-induced TF expression by suppressing NF-B DNA binding
activity as determined by gel-shift analysis. Further, inhibition of
Erk-1/2 protein by antisense treatment resulted in suppression of TF
mRNA expression, indicating a role for Erk-1/2 in modulating NF-B
DNA binding activity. These studies suggest that the induced expression
of TF by OSM is primarily through the activation of NF-B and that
activation of NF-B is regulated in part by the MEK/Erk-1/2 signal
transduction pathway. This study indicates that OSM may play a key role
in promoting TF expression in SMCs within atherosclerotic lesions.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. P. Kastl, W. S. Speidl, K. M. Katsaros, C. Kaun, G. Rega, A. Assadian, G. W. Hagmueller, M. Hoeth, R. de Martin, Y. Ma, et al.
Thrombin induces the expression of oncostatin M via AP-1 activation in human macrophages: a link between coagulation and inflammation
Blood,
September 24, 2009;
114(13):
2812 - 2818.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Kinev and R. Roubey
Tissue factor in the antiphospholipid syndrome
Lupus,
October 1, 2008;
17(10):
953 - 959.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Demyanets, C. Kaun, K. Rychli, G. Rega, S. Pfaffenberger, T. Afonyushkin, V. N. Bochkov, G. Maurer, K. Huber, and J. Wojta
The inflammatory cytokine oncostatin M induces PAI-1 in human vascular smooth muscle cells in vitro via PI 3-kinase and ERK1/2-dependent pathways
Am J Physiol Heart Circ Physiol,
September 1, 2007;
293(3):
H1962 - H1968.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. S. Wijelath, S. Rahman, M. Namekata, J. Murray, T. Nishimura, Z. Mostafavi-Pour, Y. Patel, Y. Suda, M. J. Humphries, and M. Sobel
Heparin-II Domain of Fibronectin Is a Vascular Endothelial Growth Factor-Binding Domain: Enhancement of VEGF Biological Activity by a Singular Growth Factor/Matrix Protein Synergism
Circ. Res.,
October 13, 2006;
99(8):
853 - 860.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Yu, L. May, V. Lhotak, S. Shahrzad, S. Shirasawa, J. I. Weitz, B. L. Coomber, N. Mackman, and J. W. Rak
Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis
Blood,
February 15, 2005;
105(4):
1734 - 1741.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-T. Walsh, D. R. Curran, P. J. Kingham, R. K. Morgan, N. Durcan, G. J. Gleich, W. G. McLean, and R. W. Costello
Effect of Eosinophil Adhesion on Intracellular Signaling in Cholinergic Nerve Cells
Am. J. Respir. Cell Mol. Biol.,
March 1, 2004;
30(3):
333 - 341.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Amin, O. V. Volpert, J. M. Woods, P. Kumar, L. A. Harlow, and A. E. Koch
Migration Inhibitory Factor Mediates Angiogenesis via Mitogen-Activated Protein Kinase and Phosphatidylinositol Kinase
Circ. Res.,
August 22, 2003;
93(4):
321 - 329.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. M. Watson, A. K. C. Chan, L. R. Berry, J. Li, S. K. Sood, J. G. Dickhout, L. Xu, G. H. Werstuck, L. Bajzar, H. J. Klamut, et al.
Overexpression of the 78-kDa Glucose-regulated Protein/Immunoglobulin-binding Protein (GRP78/BiP) Inhibits Tissue Factor Procoagulant Activity
J. Biol. Chem.,
May 2, 2003;
278(19):
17438 - 17447.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Nagata, H. Kai, R. Shibata, M. Koga, A. Yoshimura, and T. Imaizumi
Oncostatin M, an Interleukin-6 Family Cytokine, Upregulates Matrix Metalloproteinase-9 Through the Mitogen-Activated Protein Kinase Kinase-Extracellular Signal-Regulated Kinase Pathway in Cultured Smooth Muscle Cells
Arterioscler Thromb Vasc Biol,
April 1, 2003;
23(4):
588 - 593.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. M. Morel, C. C. Park, K. Zhu, P. Kumar, J. H. Ruth, and A. E. Koch
Signal Transduction Pathways Involved in Rheumatoid Arthritis Synovial Fibroblast Interleukin-18-induced Vascular Cell Adhesion Molecule-1 Expression
J. Biol. Chem.,
September 13, 2002;
277(38):
34679 - 34691.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Shioi, M. Katagi, Y. Okuno, K. Mori, S. Jono, H. Koyama, and Y. Nishizawa
Induction of Bone-Type Alkaline Phosphatase in Human Vascular Smooth Muscle Cells: Roles of Tumor Necrosis Factor-{alpha} and Oncostatin M Derived From Macrophages
Circ. Res.,
July 12, 2002;
91(1):
9 - 16.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Nakamura, R. Ouchida, T. Kodama, T. Kawashima, Y. Makino, N. Yoshikawa, S. Watanabe, C. Morimoto, T. Kitamura, and H. Tanaka
Cytokine Receptor Common beta Subunit-mediated STAT5 Activation Confers NF-kappa B Activation in Murine proB Cell Line Ba/F3 Cells
J. Biol. Chem.,
February 15, 2002;
277(8):
6254 - 6265.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Bierhaus, S. Schiekofer, M. Schwaninger, M. Andrassy, P. M. Humpert, J. Chen, M. Hong, T. Luther, T. Henle, I. Kloting, et al.
Diabetes-Associated Sustained Activation of the Transcription Factor Nuclear Factor-{kappa}B
Diabetes,
December 1, 2001;
50(12):
2792 - 2808.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
