SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sawano, A. Articles by Shibuya, M. Search for Related Content PubMed PubMed Citation Articles by Sawano, A. Articles by Shibuya, M. Related Collections Phagocytes Cell Adhesion and Motility Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 February 2001, Vol. 97, No. 3, pp. 785-791 PHAGOCYTES Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans Asako Sawano, Shinobu Iwai, Yoshiko Sakurai, Mikito Ito, Kenya Shitara, Tatsutoshi Nakahata, and Masabumi Shibuya From the Department of Genetics and Department of Clinical Oncology, Institute of Medical Science, University of Tokyo, and Tokyo Research Laboratories, Kyowa Hakko Kogyo Co, Ltd, Japan. Flt-1, also known as vascular endothelial growth factor receptor 1 (VEGFR-1), is a high-affinity tyrosine kinase receptor for VEGF and is expressed almost exclusively on vascular endothelial cells. As an exception, Flt-1 transcript was recently found to be expressed in human peripheral blood monocytes. However, the protein of the Flt-1 receptor on the cell surface of monocytes is yet to be identified, and whether the Flt-1 protein is expressed during the differentiation of monocyte-macrophage lineage cells has not been examined. Using monoclonal antibodies against 2 different antigenic epitopes on the Flt-1 extracellular domain, this study found that the major population of the monocyte-marker CD97+ cells in human peripheral blood express Flt-1 as a cell surface molecule. VEGFR-2 (KDR/Flk-1) was not expressed at detectable levels in these cells. An Flt-1 neutralizing monoclonal antibody significantly suppressed VEGF-induced migration of the monocytes, suggesting an important role for Flt-1 in the biologic function of monocytes. Furthermore, CD34+ cells in human cord blood, originally negative for the Flt-1 expression, differentiated into Flt-1+ cells in association with the appearance of monocyte-macrophage markers after a 2-week culture in the presence of hematopoietic cytokines. In addition, the Flt-1+CD11b+ cell fraction from CD34+ cells was found to efficiently differentiate into multinuclear osteoclasts in the presence of macrophage colony-stimulating factor and osteoclast differentiation factor. These results strongly suggest that Flt-1 is a novel cell surface marker as well as a biologically functional molecule for monocyte-macrophage lineages in humans. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: X. Li, C. Hanson, J. L. Cmarik, and S. Ruscetti Neurodegeneration Induced by PVC-211 Murine Leukemia Virus Is Associated with Increased Levels of Vascular Endothelial Growth Factor and Macrophage Inflammatory Protein 1{alpha} and Is Inhibited by Blocking Activation of Microglia J. Virol., May 15, 2009; 83(10): 4912 - 4922. [Abstract] [Full Text] [PDF] K. J. Way, H. Dinh, M. R. Keene, K. E. White, F. I. L. Clanchy, P. Lusby, J. Roiniotis, A. D. Cook, A. I. Cassady, D. J. Curtis, et al. The generation and properties of human macrophage populations from hemopoietic stem cells J. Leukoc. Biol., May 1, 2009; 85(5): 766 - 778. [Abstract] [Full Text] [PDF] W. Mu, D. A. Long, X. Ouyang, A. Agarwal, P. E. Cruz, C. A. Roncal, T. Nakagawa, X. Yu, W. W. Hauswirth, and R. J. Johnson Angiostatin overexpression is associated with an improvement in chronic kidney injury by an anti-inflammatory mechanism Am J Physiol Renal Physiol, January 1, 2009; 296(1): F145 - F152. [Abstract] [Full Text] [PDF] S. Ponticelli, D. Marasco, V. Tarallo, R. J. C. Albuquerque, S. Mitola, A. Takeda, J.-M. Stassen, M. Presta, J. Ambati, M. Ruvo, et al. Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor 1 J. Biol. Chem., December 5, 2008; 283(49): 34250 - 34259. [Abstract] [Full Text] [PDF] M. Kerber, Y. Reiss, A. Wickersheim, M. Jugold, F. Kiessling, M. Heil, V. Tchaikovski, J. Waltenberger, M. Shibuya, K. H. Plate, et al. Flt-1 Signaling in Macrophages Promotes Glioma Growth In vivo Cancer Res., September 15, 2008; 68(18): 7342 - 7351. [Abstract] [Full Text] [PDF] J.-i. Nishi, T. Minamino, H. Miyauchi, A. Nojima, K. Tateno, S. Okada, M. Orimo, J. Moriya, G.-H. Fong, K. Sunagawa, et al. Vascular Endothelial Growth Factor Receptor-1 Regulates Postnatal Angiogenesis Through Inhibition of the Excessive Activation of Akt Circ. Res., August 1, 2008; 103(3): 261 - 268. [Abstract] [Full Text] [PDF] C. Halin, H. Fahrngruber, J. G. Meingassner, G. Bold, A. Littlewood-Evans, A. Stuetz, and M. Detmar Inhibition of Chronic and Acute Skin Inflammation by Treatment with a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor Am. J. Pathol., July 1, 2008; 173(1): 265 - 277. [Abstract] [Full Text] [PDF] S. P. Dineen, K. D. Lynn, S. E. Holloway, A. F. Miller, J. P. Sullivan, D. S. Shames, A. W. Beck, C. C. Barnett, J. B. Fleming, and R. A. Brekken Vascular Endothelial Growth Factor Receptor 2 Mediates Macrophage Infiltration into Orthotopic Pancreatic Tumors in Mice Cancer Res., June 1, 2008; 68(11): 4340 - 4346. [Abstract] [Full Text] [PDF] K. Izumi-Nagai, N. Nagai, K. Ohgami, S. Satofuka, Y. Ozawa, K. Tsubota, S. Ohno, Y. Oike, and S. Ishida Inhibition of Choroidal Neovascularization with an Anti-Inflammatory Carotenoid Astaxanthin Invest. Ophthalmol. Vis. Sci., April 1, 2008; 49(4): 1679 - 1685. [Abstract] [Full Text] [PDF] M. Murakami, Y. Zheng, M. Hirashima, T. Suda, Y. Morita, J. Ooehara, H. Ema, G.-H. Fong, and M. Shibuya VEGFR1 Tyrosine Kinase Signaling Promotes Lymphangiogenesis as Well as Angiogenesis Indirectly via Macrophage Recruitment Arterioscler. Thromb. Vasc. Biol., April 1, 2008; 28(4): 658 - 664. [Abstract] [Full Text] [PDF] S. Soro, A. Orecchia, L. Morbidelli, P. M. Lacal, V. Morea, K. Ballmer-Hofer, F. Ruffini, M. Ziche, S. D'Atri, G. Zambruno, et al. A proangiogenic peptide derived from vascular endothelial growth factor receptor-1 acts through {alpha}5{beta}1 integrin Blood, April 1, 2008; 111(7): 3479 - 3488. [Abstract] [Full Text] [PDF] D. Xing, F. G. Hage, Y.-F. Chen, M. A. McCrory, W. Feng, G. A. Skibinski, E. Majid-Hassan, S. Oparil, and A. J. Szalai Exaggerated Neointima Formation in Human C-Reactive Protein Transgenic Mice Is IgG Fc Receptor Type I (Fc{gamma}RI)-Dependent Am. J. Pathol., January 1, 2008; 172(1): 22 - 30. [Abstract] [Full Text] [PDF] M. Itaya, E. Sakurai, M. Nozaki, K. Yamada, S. Yamasaki, K. Asai, and Y. Ogura Upregulation of VEGF in Murine Retina via Monocyte Recruitment after Retinal Scatter Laser Photocoagulation Invest. Ophthalmol. Vis. Sci., December 1, 2007; 48(12): 5677 - 5683. [Abstract] [Full Text] [PDF] R. Lima e Silva, J. Shen, S. F. Hackett, S. Kachi, H. Akiyama, K. Kiuchi, K. Yokoi, M. C. Hatara, T. Lauer, S. Aslam, et al. The SDF-1/CXCR4 ligand/receptor pair is an important contributor to several types of ocular neovascularization FASEB J, October 1, 2007; 21(12): 3219 - 3230. [Abstract] [Full Text] [PDF] J.-S. Choi, H.-Y. Kim, J.-H. Cha, J.-Y. Choi, S. I. Park, C. H. Jeong, S.-S. Jeun, and M.-Y. Lee Upregulation of Vascular Endothelial Growth Factor Receptors Flt-1 and Flk-1 Following Acute Spinal Cord Contusion in Rats J. Histochem. Cytochem., August 1, 2007; 55(8): 821 - 830. [Abstract] [Full Text] [PDF] Y. Huang, X. Chen, M. M. Dikov, S. V. Novitskiy, C. A. Mosse, L. Yang, and D. P. Carbone Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF Blood, July 15, 2007; 110(2): 624 - 631. [Abstract] [Full Text] [PDF] K. Krenn, W. Klepetko, S. Taghavi, P. Paulus, and S. Aharinejad Vascular endothelial growth factor increases pulmonary vascular permeability in cystic fibrosis patients undergoing lung transplantation Eur. J. Cardiothorac. Surg., July 1, 2007; 32(1): 35 - 41. [Abstract] [Full Text] [PDF] M. Nagano, T. Yamashita, H. Hamada, K. Ohneda, K.-i. Kimura, T. Nakagawa, M. Shibuya, H. Yoshikawa, and O. Ohneda Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood Blood, July 1, 2007; 110(1): 151 - 160. [Abstract] [Full Text] [PDF] A. Norden-Zfoni, J. Desai, J. Manola, P. Beaudry, J. Force, R. Maki, J. Folkman, C. Bello, C. Baum, S. E. DePrimo, et al. Blood-Based Biomarkers of SU11248 Activity and Clinical Outcome in Patients with Metastatic Imatinib-Resistant Gastrointestinal Stromal Tumor Clin. Cancer Res., May 1, 2007; 13(9): 2643 - 2650. [Abstract] [Full Text] [PDF] O. Raisky, A. I. Nykanen, R. Krebs, M. Hollmen, M. A.I. Keranen, J. M. Tikkanen, R. Sihvola, L. Alhonen, P. Salven, Y. Wu, et al. VEGFR-1 and -2 Regulate Inflammation, Myocardial Angiogenesis, and Arteriosclerosis in Chronically Rejecting Cardiac Allografts Arterioscler. Thromb. Vasc. Biol., April 1, 2007; 27(4): 819 - 825. [Abstract] [Full Text] [PDF] G. Shinoda, K. Umeda, T. Heike, M. Arai, A. Niwa, F. Ma, H. Suemori, H. Y. Luo, D. H. K. Chui, R. Torii, et al. {alpha}4-Integrin+ endothelium derived from primate embryonic stem cells generates primitive and definitive hematopoietic cells Blood, March 15, 2007; 109(6): 2406 - 2415. [Abstract] [Full Text] [PDF] A. Srikiatkhachorn, C. Ajariyakhajorn, T. P. Endy, S. Kalayanarooj, D. H. Libraty, S. Green, F. A. Ennis, and A. L. Rothman Virus-Induced Decline in Soluble Vascular Endothelial Growth Receptor 2 Is Associated with Plasma Leakage in Dengue Hemorrhagic Fever J. Virol., February 15, 2007; 81(4): 1592 - 1600. [Abstract] [Full Text] [PDF] S. Satofuka, A. Ichihara, N. Nagai, T. Koto, H. Shinoda, K. Noda, Y. Ozawa, M. Inoue, K. Tsubota, H. Itoh, et al. Role of Nonproteolytically Activated Prorenin in Pathologic, but Not Physiologic, Retinal Neovascularization Invest. Ophthalmol. Vis. Sci., January 1, 2007; 48(1): 422 - 429. [Abstract] [Full Text] [PDF] R. N. Kaplan, S. Rafii, and D. Lyden Preparing the "Soil": The Premetastatic Niche Cancer Res., December 1, 2006; 66(23): 11089 - 11093. [Abstract] [Full Text] [PDF] A. E. M. Dirkx, M. G. A. oude Egbrink, J. Wagstaff, and A. W. Griffioen Monocyte/macrophage infiltration in tumors: modulators of angiogenesis J. Leukoc. Biol., December 1, 2006; 80(6): 1183 - 1196. [Abstract] [Full Text] [PDF] K. Umeda, T. Heike, M. Nakata-Hizume, A. Niwa, M. Arai, G. Shinoda, F. Ma, H. Suemori, H. Y. Luo, D. H. K. Chui, et al. Sequential Analysis of {alpha}- and {beta}-Globin Gene Expression During Erythropoietic Differentiation from Primate Embryonic Stem Cells Stem Cells, December 1, 2006; 24(12): 2627 - 2636. [Abstract] [Full Text] [PDF] K. A. Mohamedali, A. T. Poblenz, C. R. Sikes, N. M. Navone, P. E. Thorpe, B. G. Darnay, and M. G. Rosenblum Inhibition of Prostate Tumor Growth and Bone Remodeling by the Vascular Targeting Agent VEGF121/rGel. Cancer Res., November 15, 2006; 66(22): 10919 - 10928. [Abstract] [Full Text] [PDF] A. de Paulis, N. Prevete, I. Fiorentino, F. W. Rossi, S. Staibano, N. Montuori, P. Ragno, A. Longobardi, B. Liccardo, A. Genovese, et al. Expression and Functions of the Vascular Endothelial Growth Factors and Their Receptors in Human Basophils J. Immunol., November 15, 2006; 177(10): 7322 - 7331. [Abstract] [Full Text] [PDF] Y. Wu, Z. Zhong, J. Huber, R. Bassi, B. Finnerty, E. Corcoran, H. Li, E. Navarro, P. Balderes, X. Jimenez, et al. Anti-vascular endothelial growth factor receptor-1 antagonist antibody as a therapeutic agent for cancer. Clin. Cancer Res., November 1, 2006; 12(21): 6573 - 6584. [Abstract] [Full Text] [PDF] A. C. Aplin, M. Gelati, E. Fogel, E. Carnevale, and R. F. Nicosia Angiopoietin-1 and vascular endothelial growth factor induce expression of inflammatory cytokines before angiogenesis Physiol Genomics, October 3, 2006; 27(1): 20 - 28. [Abstract] [Full Text] [PDF] C. Lamagna, M. Aurrand-Lions, and B. A. Imhof Dual role of macrophages in tumor growth and angiogenesis J. Leukoc. Biol., October 1, 2006; 80(4): 705 - 713. [Abstract] [Full Text] [PDF] M. Murakami, S. Iwai, S. Hiratsuka, M. Yamauchi, K. Nakamura, Y. Iwakura, and M. Shibuya Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages Blood, September 15, 2006; 108(6): 1849 - 1856. [Abstract] [Full Text] [PDF] Y. Zheng, M. Murakami, H. Takahashi, M. Yamauchi, A. Kiba, S. Yamaguchi, N. Yabana, K. Alitalo, and M. Shibuya Chimeric VEGF-ENZ7/PlGF Promotes Angiogenesis Via VEGFR-2 Without Significant Enhancement of Vascular Permeability and Inflammation Arterioscler. Thromb. Vasc. Biol., September 1, 2006; 26(9): 2019 - 2026. [Abstract] [Full Text] [PDF] W. Li, W. Shen, R. Gill, A. Corbly, B. Jones, R. Belagaje, Y. Zhang, S. Tang, Y. Chen, Y. Zhai, et al. High-Resolution Quantitative Computed Tomography Demonstrating Selective Enhancement of Medium-Size Collaterals by Placental Growth Factor-1 in the Mouse Ischemic Hindlimb Circulation, May 23, 2006; 113(20): 2445 - 2453. [Abstract] [Full Text] [PDF] C. A. Eisenberg, J. B.E. Burch, and L. M. Eisenberg Bone Marrow Cells Transdifferentiate to Cardiomyocytes When Introduced into the Embryonic Heart Stem Cells, May 1, 2006; 24(5): 1236 - 1245. [Abstract] [Full Text] [PDF] K. Umeda, T. Heike, M. Yoshimoto, G. Shinoda, M. Shiota, H. Suemori, H. Y. Luo, D. H. K. Chui, R. Torii, M. Shibuya, et al. Identification and Characterization of Hemoangiogenic Progenitors During Cynomolgus Monkey Embryonic Stem Cell Differentiation Stem Cells, May 1, 2006; 24(5): 1348 - 1358. [Abstract] [Full Text] [PDF] H. Iwama, S. Uemura, N. Naya, K.-i. Imagawa, Y. Takemoto, O. Asai, K. Onoue, S. Okayama, S. Somekawa, Y. Kida, et al. Cardiac Expression of Placental Growth Factor Predicts the Improvement of Chronic Phase Left Ventricular Function in Patients With Acute Myocardial Infarction J. Am. Coll. Cardiol., April 18, 2006; 47(8): 1559 - 1567. [Abstract] [Full Text] [PDF] R. Fragoso, T. Pereira, Y. Wu, Z. Zhu, J. Cabecadas, and S. Dias VEGFR-1 (FLT-1) activation modulates acute lymphoblastic leukemia localization and survival within the bone marrow, determining the onset of extramedullary disease Blood, February 15, 2006; 107(4): 1608 - 1616. [Abstract] [Full Text] [PDF] P. A. Campochiaro and the First ARVO/Pfizer Institute Working Group Ocular versus Extraocular Neovascularization: Mirror Images or Vague Resemblances Invest. Ophthalmol. Vis. Sci., February 1, 2006; 47(2): 462 - 474. [Full Text] [PDF] A. K. Malik, M. E. Baldwin, F. Peale, G. Fuh, W.-C. Liang, H. Lowman, G. Meng, N. Ferrara, and H.-P. Gerber Redundant roles of VEGF-B and PlGF during selective VEGF-A blockade in mice Blood, January 15, 2006; 107(2): 550 - 557. [Abstract] [Full Text] [PDF] J. M. Vieira, S. C R. Santos, C. Espadinha, I. Correia, T. Vag, C. Casalou, B. M. Cavaco, A. L. Catarino, S. Dias, and V. Leite Expression of vascular endothelial growth factor (VEGF) and its receptors in thyroid carcinomas of follicular origin: a potential autocrine loop Eur. J. Endocrinol., November 1, 2005; 153(5): 701 - 709. [Abstract] [Full Text] [PDF] T. A. Wilgus, A. M. Matthies, K. A. Radek, J. V. Dovi, A. L. Burns, R. Shankar, and L. A. DiPietro Novel Function for Vascular Endothelial Growth Factor Receptor-1 on Epidermal Keratinocytes Am. J. Pathol., November 1, 2005; 167(5): 1257 - 1266. [Abstract] [Full Text] [PDF] C. Chan, J. Sandhu, A. Guha, D. A. Scollard, J. Wang, P. Chen, K. Bai, L. Lee, and R. M. Reilly A Human Transferrin-Vascular Endothelial Growth Factor (hnTf-VEGF) Fusion Protein Containing an Integrated Binding Site for 111In for Imaging Tumor Angiogenesis J. Nucl. Med., October 1, 2005; 46(10): 1745 - 1752. [Abstract] [Full Text] [PDF] E. Elsheikh, M. Uzunel, Z. He, J. Holgersson, G. Nowak, and S. Sumitran-Holgersson Only a specific subset of human peripheral-blood monocytes has endothelial-like functional capacity Blood, October 1, 2005; 106(7): 2347 - 2355. [Abstract] [Full Text] [PDF] S. Niida, T. Kondo, S. Hiratsuka, S.-I. Hayashi, N. Amizuka, T. Noda, K. Ikeda, and M. Shibuya VEGF receptor 1 signaling is essential for osteoclast development and bone marrow formation in colony-stimulating factor 1-deficient mice PNAS, September 27, 2005; 102(39): 14016 - 14021. [Abstract] [Full Text] [PDF] A. W. Mould, S. A. Greco, M. M. Cahill, I. D. Tonks, D. Bellomo, C. Patterson, A. Zournazi, A. Nash, P. Scotney, N. K. Hayward, et al. Transgenic Overexpression of Vascular Endothelial Growth Factor-B Isoforms by Endothelial Cells Potentiates Postnatal Vessel Growth In Vivo and In Vitro Circ. Res., September 16, 2005; 97(6): e60 - e70. [Abstract] [Full Text] [PDF] R. Khurana, L. Moons, S. Shafi, A. Luttun, D. Collen, J. F. Martin, P. Carmeliet, and I. C. Zachary Placental Growth Factor Promotes Atherosclerotic Intimal Thickening and Macrophage Accumulation Circulation, May 31, 2005; 111(21): 2828 - 2836. [Abstract] [Full Text] [PDF] B. A. Mosheimer, N. C. Kaneider, C. Feistritzer, A. M. Djanani, D. H. Sturn, J. R. Patsch, and C. J. Wiedermann Syndecan-1 Is Involved in Osteoprotegerin-Induced Chemotaxis in Human Peripheral Blood Monocytes J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2964 - 2971. [Abstract] [Full Text] [PDF] S. A. McGrath-Morrow, C. Cho, C. Cho, L. Zhen, D. J. Hicklin, and R. M. Tuder Vascular Endothelial Growth Factor Receptor 2 Blockade Disrupts Postnatal Lung Development Am. J. Respir. Cell Mol. Biol., May 1, 2005; 32(5): 420 - 427. [Abstract] [Full Text] [PDF] N. Nagai, K. Noda, T. Urano, Y. Kubota, H. Shinoda, T. Koto, K. Shinoda, M. Inoue, T. Shiomi, E. Ikeda, et al. Selective Suppression of Pathologic, but Not Physiologic, Retinal Neovascularization by Blocking the Angiotensin II Type 1 Receptor Invest. Ophthalmol. Vis. Sci., March 1, 2005; 46(3): 1078 - 1084. [Abstract] [Full Text] [PDF] X. Jimenez, D. Lu, L. Brennan, K. Persaud, M. Liu, H. Miao, L. Witte, and Z. Zhu A recombinant, fully human, bispecific antibody neutralizes the biological activities mediated by both vascular endothelial growth factor receptors 2 and 3 Mol. Cancer Ther., March 1, 2005; 4(3): 427 - 434. [Abstract] [Full Text] [PDF] K. Podar and K. C. Anderson The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications Blood, February 15, 2005; 105(4): 1383 - 1395. [Abstract] [Full Text] [PDF] K. R. Stenmark, N. J. Davie, J. T. Reeves, and M. G. Frid Hypoxia, leukocytes, and the pulmonary circulation J Appl Physiol, February 1, 2005; 98(2): 715 - 721. [Abstract] [Full Text] [PDF] M. M. Dikov, J. E. Ohm, N. Ray, E. E. Tchekneva, J. Burlison, D. Moghanaki, S. Nadaf, and D. P. Carbone Differential Roles of Vascular Endothelial Growth Factor Receptors 1 and 2 in Dendritic Cell Differentiation J. Immunol., January 1, 2005; 174(1): 215 - 222. [Abstract] [Full Text] [PDF] G. Nowak, A. Karrar, C. Holmen, S. Nava, M. Uzunel, K. Hultenby, and S. Sumitran-Holgersson Expression of Vascular Endothelial Growth Factor Receptor-2 or Tie-2 on Peripheral Blood Cells Defines Functionally Competent Cell Populations Capable of Reendothelialization Circulation, December 14, 2004; 110(24): 3699 - 3707. [Abstract] [Full Text] [PDF] C. Murdoch, A. Giannoudis, and C. E. Lewis Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues Blood, October 15, 2004; 104(8): 2224 - 2234. [Abstract] [Full Text] [PDF] T. Ostendorf, C. van Roeyen, R. Westenfeld, A. Gawlik, M. Kitahara, E. de Heer, D. Kerjaschki, J. Floege, and M. Ketteler Inducible Nitric Oxide Synthase-Derived Nitric Oxide Promotes Glomerular Angiogenesis via Upregulation of Vascular Endothelial Growth Factor Receptors J. Am. Soc. Nephrol., September 1, 2004; 15(9): 2307 - 2319. [Abstract] [Full Text] [PDF] Z. F. Yang, R. T. Poon, Y. Luo, C. K. Cheung, D. W. Ho, C. M. Lo, and S. T. Fan Up-Regulation of Vascular Endothelial Growth Factor (VEGF) in Small-for-Size Liver Grafts Enhances Macrophage Activities through VEGF Receptor 2-Dependent Pathway J. Immunol., August 15, 2004; 173(4): 2507 - 2515. [Abstract] [Full Text] [PDF] J. M.L. Ebos, G. Bocci, S. Man, P. E. Thorpe, D. J. Hicklin, D. Zhou, X. Jia, and R. S. Kerbel A Naturally Occurring Soluble Form of Vascular Endothelial Growth Factor Receptor 2 Detected in Mouse and Human Plasma Mol. Cancer Res., June 1, 2004; 2(6): 315 - 326. [Abstract] [Full Text] [PDF] K. Umeda, T. Heike, M. Yoshimoto, M. Shiota, H. Suemori, H. Y. Luo, D. H. K. Chui, R. Torii, M. Shibuya, N. Nakatsuji, et al. Development of primitive and definitive hematopoiesis from nonhuman primate embryonic stem cells in vitro Development, April 15, 2004; 131(8): 1869 - 1879. [Abstract] [Full Text] [PDF] J. Walter-Yohrling, S. Morgenbesser, C. Rouleau, R. Bagley, M. Callahan, W. Weber, and B. A. Teicher Murine Endothelial Cell Lines as Models of Tumor Endothelial Cells Clin. Cancer Res., March 15, 2004; 10(6): 2179 - 2189. [Abstract] [Full Text] [PDF] T. Usui, S. Ishida, K. Yamashiro, Y. Kaji, V. Poulaki, J. Moore, T. Moore, S. Amano, Y. Horikawa, D. Dartt, et al. VEGF164(165) as the Pathological Isoform: Differential Leukocyte and Endothelial Responses through VEGFR1 and VEGFR2 Invest. Ophthalmol. Vis. Sci., February 1, 2004; 45(2): 368 - 374. [Abstract] [Full Text] [PDF] B. Chazaud, C. Sonnet, P. Lafuste, G. Bassez, A.-C. Rimaniol, F. Poron, F.-J. Authier, P. A. Dreyfus, and R. K. Gherardi Satellite cells attract monocytes and use macrophages as a support to escape apoptosis and enhance muscle growth J. Cell Biol., December 8, 2003; 163(5): 1133 - 1143. [Abstract] [Full Text] [PDF] H. Okuyama, M. Tsuneto, T. Yamane, H. Yamazaki, and S.-I. Hayashi Discrete Types of Osteoclast Precursors Can Be Generated from Embryonic Stem Cells Stem Cells, November 1, 2003; 21(6): 670 - 680. [Abstract] [Full Text] [PDF] M.-A. Pascaud, F. Griscelli, W. Raoul, E. Marcos, P. Opolon, B. Raffestin, M. Perricaudet, S. Adnot, and S. Eddahibi Lung Overexpression of Angiostatin Aggravates Pulmonary Hypertension in Chronically Hypoxic Mice Am. J. Respir. Cell Mol. Biol., October 1, 2003; 29(4): 449 - 457. [Abstract] [Full Text] [PDF] A. Orecchia, P. M. Lacal, C. Schietroma, V. Morea, G. Zambruno, and C. M. Failla Vascular endothelial growth factor receptor-1 is deposited in the extracellular matrix by endothelial cells and is a ligand for the {alpha}5{beta}1 integrin J. Cell Sci., September 1, 2003; 116(17): 3479 - 3489. [Abstract] [Full Text] [PDF] N. Perelman, S. K. Selvaraj, S. Batra, L. R. Luck, A. Erdreich-Epstein, T. D. Coates, V. K. Kalra, and P. Malik Placenta growth factor activates monocytes and correlates with sickle cell disease severity Blood, August 15, 2003; 102(4): 1506 - 1514. [Abstract] [Full Text] [PDF] M. Sone, H. Itoh, J. Yamashita, T. Yurugi-Kobayashi, Y. Suzuki, Y. Kondo, A. Nonoguchi, N. Sawada, K. Yamahara, K. Miyashita, et al. Different Differentiation Kinetics of Vascular Progenitor Cells in Primate and Mouse Embryonic Stem Cells Circulation, April 29, 2003; 107(16): 2085 - 2088. [Abstract] [Full Text] [PDF] I. Casella, T. Feccia, C. Chelucci, P. Samoggia, G. Castelli, R. Guerriero, I. Parolini, E. Petrucci, E. Pelosi, O. Morsilli, et al. Autocrine-paracrine VEGF loops potentiate the maturation of megakaryocytic precursors through Flt1 receptor Blood, February 15, 2003; 101(4): 1316 - 1323. [Abstract] [Full Text] [PDF] R. E. Bachelder, M. A. Wendt, and A. M. Mercurio Vascular Endothelial Growth Factor Promotes Breast Carcinoma Invasion in an Autocrine Manner by Regulating the Chemokine Receptor CXCR4 Cancer Res., December 15, 2002; 62(24): 7203 - 7206. [Abstract] [Full Text] [PDF] D. A. Hume, I. L. Ross, S. R. Himes, R. T. Sasmono, C. A. Wells, and T. Ravasi The mononuclear phagocyte system revisited J. Leukoc. Biol., October 1, 2002; 72(4): 621 - 627. [Abstract] [Full Text] [PDF] D. Mason, P. Andre, A. Bensussan, C. Buckley, C. Civin, E. Clark, M. de Haas, S. Goyert, M. Hadam, D. Hart, et al. CD antigens 2002 Blood, May 15, 2002; 99(10): 3877 - 3880. [Full Text] [PDF] A. Adini, T. Kornaga, F. Firoozbakht, and L. E. Benjamin Placental Growth Factor Is a Survival Factor for Tumor Endothelial Cells and Macrophages Cancer Res., May 1, 2002; 62(10): 2749 - 2752. [Abstract] [Full Text] [PDF] K.-i. Minehata, Y.-s. Mukouyama, T. Sekiguchi, T. Hara, and A. Miyajima Macrophage colony stimulating factor modulates the development of hematopoiesis by stimulating the differentiation of endothelial cells in the AGM region Blood, April 1, 2002; 99(7): 2360 - 2368. [Abstract] [Full Text] [PDF] J. B. Kearney, C. A. Ambler, K.-A. Monaco, N. Johnson, R. G. Rapoport, and V. L. Bautch Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division Blood, April 1, 2002; 99(7): 2397 - 2407. [Abstract] [Full Text] [PDF] D. Mason, P. Andre, A. Bensussan, C. Buckley, C. Civin, E. Clark, M. de Haas, S. Goyert, M. Hadam, D. Hart, et al. CD antigens 2001 J. Leukoc. Biol., November 1, 2001; 70(5): 685 - 690. [Abstract] [Full Text] [PDF] D. Mason, P. Andre, A. Bensussan, C. Buckley, C. Civin, E. Clark, M. de Haas, S. Goyert, M. Hadam, D. Hart, et al. CD Antigens 2001: Aims and Results of HLDA Workshops Stem Cells, November 1, 2001; 19(6): 556 - 562. [Full Text] R. J. Klasa, A. F. List, and B. D. Cheson Rational Approaches to Design of Therapeutics Targeting Molecular Markers Hematology, January 1, 2001; 2001(1): 443 - 462. [Abstract] [Full Text] [PDF] M. Papetti and I. M. Herman Mechanisms of normal and tumor-derived angiogenesis Am J Physiol Cell Physiol, May 1, 2002; 282(5): C947 - C970. [Abstract] [Full Text] [PDF]

	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020