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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Avet-Loiseau, H. Articles by Bataille, R. Search for Related Content PubMed PubMed Citation Articles by Avet-Loiseau, H. Articles by Bataille, R. Related Collections Neoplasia Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 February 2001, Vol. 97, No. 3, pp. 822-825 BRIEF REPORT Cytogenetic, interphase, and multicolor fluorescence in situ hybridization analyses in primary plasma cell leukemia: a study of 40 patients at diagnosis, on behalf of the Intergroupe Francophone du Myélome and the Groupe Français de Cytogénétique Hématologique Hervé Avet-Loiseau, Axelle Daviet, Christophe Brigaudeau, Evelyne Callet-Bauchu, Christine Terré, Marina Lafage-Pochitaloff, François Désangles, Sylvie Ramond, Pascaline Talmant, and Régis Bataille From the Laboratory of Hematology, University Hospital, Nantes, France; Laboratory of Hematology, University Hospital, Limoges, France; Laboratory of Hematology, Hopital Lyon-Sud, Pierre-Bénite, France; Laboratory of Cytogenetics, General Hospital, Versailles; Laboratory of Cytogenetics, Institute Paoli-Calmette, Marseille, France; and Laboratory of Cytogenetics, Hospital Val-de-Grace, and Laboratory of Hematology, Hotel-Dieu, Paris, France. Primary plasma cell leukemia (PCL) is a rare plasma cell malignancy. Consequently, few large reports have been published. Presented is a cytogenetic analysis of 40 patients with primary PCL compared with 247 newly diagnosed patients with stage III multiple myeloma (MM). Cytogenetic abnormalities were observed in 23 of 34 patients, with usually complex hypodiploid or pseudodiploid karyotypes. Analysis of rearrangements of the 14q32 region revealed significant differences with high cell mass MMa higher incidence of t(11;14) (33% vs 16%; P < .025) and of t(14;16) (13% vs 1%; P < .002) though incidences of t(4;14) were identical and a higher incidence of monosomy 13 (68% vs 42%; P = .005). Hypodiploid karyotypes and monosomy 13 may explain, at least in part, the poorer prognosis of primary PCL. In contrast, significantly longer survival was observed in patients displaying t(11;14) in comparison with those lacking this translocation (P = .001). © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020