|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 February 2001, Vol. 97, No. 4, pp. 1035-1042
IMMUNOBIOLOGY
Interleukin 9 promotes influx and local maturation of
eosinophils
Jamila Louahed,
Yuhong Zhou,
W. Lee Maloy,
Pyapalli U. Rani,
Christine Weiss,
Yaniv Tomer,
Anne Vink,
Jean-Christophe Renauld,
Jacques Van Snick,
Nicholas C. Nicolaides,
Roy C. Levitt, and
Angela Haczku
From the Magainin Institute of Molecular
Medicine, Magainin Pharmaceuticals, Inc, Plymouth Meeting, PA; Ludwig
Institute for Cancer Research, Brussels Branch, and the Experimental
Medicine Unit, University of Louvain, Brussels, Belgium.
The interleukin 9 (IL-9) pathway has recently been associated
with the asthmatic phenotype including an eosinophilic tissue inflammation. The mechanism by which IL-9 affects eosinophils (eos) is
not known. To investigate whether this cytokine has a direct activity
on the development of eos and eosinophilic inflammation, a model of
thioglycolate-induced peritoneal inflammation was used in IL-9
transgenic (TG5) and background strain (FVB) mice. In this model, a
transient eosinophilic infiltration in the peritoneal cavity was
observed in FVB mice 12 to 24 hours after thioglycolate injection that
coincided with peak IL-5 and IL-9 release. In contrast, TG5 mice
developed a massive eosinophilia that persisted at high levels (81% of
total cells) even 72 hours after thioglycolate injection. Release of
eosinophilic major basic protein (MBP), IL-4, and IL-5 to the
peritoneal cavity of these mice was significantly increased when
compared with the control FVB strain. To study the mechanism by which
IL-9 exerts its effect on eos, bone marrow or peritoneal cells were
cultured in the presence of IL-5, IL-9, or their combination in
vitro. IL-5 alone was able to generate significant numbers of eos in
TG5 but not FVB mice, whereas a combination of IL-5 and IL-9 induced
marked eosinophilia in both strains indicating a synergism between
these 2 cytokines. These data suggest that IL-9 may promote and sustain
eosinophilic inflammation via IL-5-driven eos maturation of precursors.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
E. E. Forbes, K. Groschwitz, J. P. Abonia, E. B. Brandt, E. Cohen, C. Blanchard, R. Ahrens, L. Seidu, A. McKenzie, R. Strait, et al.
IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity
J. Exp. Med.,
April 14, 2008;
205(4):
897 - 913.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. van den Brule, J. Heymans, X. Havaux, J.-C. Renauld, D. Lison, F. Huaux, and O. Denis
Profibrotic Effect of IL-9 Overexpression in a Model of Airway Remodeling
Am. J. Respir. Cell Mol. Biol.,
August 1, 2007;
37(2):
202 - 209.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Steenwinckel, J. Louahed, C. Orabona, F. Huaux, G. Warnier, A. McKenzie, D. Lison, R. Levitt, and J.-C. Renauld
IL-13 Mediates In Vivo IL-9 Activities on Lung Epithelial Cells but Not on Hematopoietic Cells
J. Immunol.,
March 1, 2007;
178(5):
3244 - 3251.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G.-H. Chen, M. A. Olszewski, R. A. McDonald, J. C. Wells, R. Paine III, G. B. Huffnagle, and G. B. Toews
Role of Granulocyte Macrophage Colony-Stimulating Factor in Host Defense Against Pulmonary Cryptococcus neoformans Infection during Murine Allergic Bronchopulmonary Mycosis
Am. J. Pathol.,
March 1, 2007;
170(3):
1028 - 1040.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U.-A. Temann, Y. Laouar, E. E. Eynon, R. Homer, and R. A. Flavell
IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells
Int. Immunol.,
January 1, 2007;
19(1):
1 - 10.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Arendse, J. Van Snick, and F. Brombacher
IL-9 Is a Susceptibility Factor in Leishmania major Infection by Promoting Detrimental Th2/Type 2 Responses
J. Immunol.,
February 15, 2005;
174(4):
2205 - 2211.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Reader, D. M. Hyde, E. S. Schelegle, M. C. Aldrich, A. M. Stoddard, M. P. McLane, R. C. Levitt, and J. S. Tepper
Interleukin-9 Induces Mucous Cell Metaplasia Independent of Inflammation
Am. J. Respir. Cell Mol. Biol.,
June 1, 2003;
28(6):
664 - 672.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Baraldo, D. S. Faffe, P. E. Moore, T. Whitehead, M. McKenna, E. S. Silverman, R. A. Panettieri Jr., and S. A. Shore
Interleukin-9 influences chemokine release in airway smooth muscle: role of ERK
Am J Physiol Lung Cell Mol Physiol,
June 1, 2003;
284(6):
L1093 - L1102.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. M. Robertson, J. G. Zangrilli, A. Steplewski, A. Hastie, R. G. Lindemeyer, M. A. Planeta, M. K. Smith, N. Innocent, A. Musani, R. Pascual, et al.
Differential Expression of TRAIL and TRAIL Receptors in Allergic Asthmatics Following Segmental Antigen Challenge: Evidence for a Role of TRAIL in Eosinophil Survival
J. Immunol.,
November 15, 2002;
169(10):
5986 - 5996.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Pilette, Y. Ouadrhiri, J. Van Snick, J-C. Renauld, P. Staquet, J-P. Vaerman, and Y. Sibille
Oxidative burst in lipopolysaccharide-activated human alveolar macrophages is inhibited by interleukin-9
Eur. Respir. J.,
November 1, 2002;
20(5):
1198 - 1205.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Haczku, E. N. Atochina, Y. Tomer, Y. Cao, C. Campbell, S. T. Scanlon, S. J. Russo, G. Enhorning, and M. F. Beers
The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice
Am J Physiol Lung Cell Mol Physiol,
October 1, 2002;
283(4):
L755 - L765.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Sato, N. Ouellet, I. Pelletier, M. Simard, A. Rancourt, and M. G. Bergeron
Role of Galectin-3 as an Adhesion Molecule for Neutrophil Extravasation During Streptococcal Pneumonia
J. Immunol.,
February 15, 2002;
168(4):
1813 - 1822.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. McMillan, B. Bishop, M. J. Townsend, A. N. McKenzie, and C. M. Lloyd
The Absence of Interleukin 9 Does Not Affect the Development of Allergen-induced Pulmonary Inflammation nor Airway Hyperreactivity
J. Exp. Med.,
January 7, 2002;
195(1):
51 - 57.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
