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Blood, 15 February 2001, Vol. 97, No. 4, pp. 1144-1146
BRIEF REPORT
Specialized roles of the chemokine receptors CCR1 and CCR5 in the
recruitment of monocytes and TH1-like/CD45RO+
T cells
Christian Weber,
Kim S. C. Weber,
Christiane Klier,
Songhai Gu,
Rudolf Wank,
Richard Horuk, and
Peter J. Nelson
From the Institut für Prophylaxe der
Kreislaufkrankheiten, Medizinische Poliklinik, and Institut für
Immunologie, Ludwig-Maximilians-Universität München,
Munich, Germany; and Berlex Biosciences, Richmond, CA.
Chemokines and their receptors control the emigration of leukocytes
during inflammation. The role of the RANTES (regulated on activation
normal T-cell expressed and secreted) receptors CCR1 and CCR5
in the selective recruitment of monocytes, TH1-like T-cell
clones, and peripheral T cells enriched for CD45RO+
"memory" cells were tested in a system in which arrest under flow
conditions is triggered by RANTES immobilized to activated endothelium.
With the use of selective nonpeptide receptor antagonists or blocking
antibodies, it was found that the RANTES-induced arrest of these cells
was mediated predominantly by CCR1. In contrast, CCR5 mainly
contributed to the spreading in shear flow, and both CCR1 and CCR5
supported transendothelial chemotaxis toward RANTES. The data in this
study reveal specialized roles of apparently redundant receptors in
distinct steps of leukocyte trafficking and suggest that not all
receptors currently used to define mononuclear cell subsets are
involved in their direct recruitment from the circulation.
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