|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 March 2001, Vol. 97, No. 6, pp. 1525-1533
PLENARY PAPER
Interleukin-7 restores immunity in athymic
T-cell-depleted hosts
Terry J. Fry,
Barbara L. Christensen,
Kristin L. Komschlies,
Ronald E. Gress, and
Crystal L. Mackall
From the Molecular Oncology Section, Pediatric Branch,
National Cancer Institute, National Institutes of Heath,
Bethesda, Maryland; Intramural Research Support Program, SAIC
Frederick, National Cancer Institute-Frederick, Frederick, Maryland;
and Experimental Immunology Branch, National Cancer Institute, National
Institutes of Health, Bethesda, Maryland.
Thymic-deficient hosts rely primarily on antigen-driven expansion
to restore the peripheral T-cell compartment following T-cell depletion
(TCD). The degree to which this thymic-independent pathway can restore
immune competence remains poorly understood but has important
implications for a number of clinical conditions including stem cell
transplantation and human immunodeficiency virus (HIV) infection. A
model of HY-mediated skin graft rejection by athymic, TCD mice was used
to show that restoration of naive and recall responses via peripheral
expansion requires transfer of only 25 × 106 lymph node
(LN) cells representing approximately 10% of the T-cell repertoire.
Consitutive expression of bcl-2 in the expanding inocula restored
recall responses to HY at a substantially lower LN cell dose
(1 × 106), which is normally insufficient to induce
HY-mediated graft rejection in athymic hosts. Interestingly, bcl-2 had
no effect on primary responses. Interleukin-7 (IL-7) potently enhanced
thymic-independent peripheral expansion and led to HY graft rejection
using an LN cell dose of 1 × 106 in both primary and
recall models. The restoration of immune competence by IL-7 appeared to
be mediated through a combination of programmed cell death inhibition,
improved costimulation, and modulation of antigen-presenting cell (APC)
function. These results show that immune competence for even stringent
antigens such as HY can be restored in the absence of thymic function
and identify IL-7 as a potent modulator of thymic-independent T-cell regeneration.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. M. Churchman and F. Ponchel
Interleukin-7 in rheumatoid arthritis
Rheumatology,
June 1, 2008;
47(6):
753 - 759.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. N. Kochenderfer, J. L. Simpson, C. D. Chien, and R. E. Gress
Vaccination regimens incorporating CpG-containing oligodeoxynucleotides and IL-2 generate antigen-specific antitumor immunity from T-cell populations undergoing homeostatic peripheral expansion after BMT
Blood,
July 1, 2007;
110(1):
450 - 460.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Higuchi, F. O. Bartel, M. Masuya, T. Deguchi, K. W. Henderson, R. Li, R. C. Muise-Helmericks, M. J. Kern, D. K. Watson, and D. D. Spyropoulos
Thymomegaly, Microsplenia, and Defective Homeostatic Proliferation of Peripheral Lymphocytes in p51-Ets1 Isoform-Specific Null Mice
Mol. Cell. Biol.,
May 1, 2007;
27(9):
3353 - 3366.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Fluur, A. De Milito, T. J. Fry, N. Vivar, L. Eidsmo, A. Atlas, C. Federici, P. Matarrese, M. Logozzi, E. Rajnavolgyi, et al.
Potential Role for IL-7 in Fas-Mediated T Cell Apoptosis During HIV Infection
J. Immunol.,
April 15, 2007;
178(8):
5340 - 5350.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Hryniewicz, D. A. Price, M. Moniuszko, A. Boasso, Y. Edghill-Spano, S. M. West, D. Venzon, M. Vaccari, W.-P. Tsai, E. Tryniszewska, et al.
Interleukin-15 but Not Interleukin-7 Abrogates Vaccine-Induced Decrease in Virus Level in Simian Immunodeficiency Virusmac251-Infected Macaques
J. Immunol.,
March 15, 2007;
178(6):
3492 - 3504.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Harnaha, J. Machen, M. Wright, R. Lakomy, A. Styche, M. Trucco, S. Makaroun, and N. Giannoukakis
Interleukin-7 Is a Survival Factor for CD4+ CD25+ T-Cells and Is Expressed by Diabetes-Suppressive Dendritic Cells
Diabetes,
January 1, 2006;
55(1):
158 - 170.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Cooley, V. McCullar, R. Wangen, T. L. Bergemann, S. Spellman, D. J. Weisdorf, and J. S. Miller
KIR reconstitution is altered by T cells in the graft and correlates with clinical outcomes after unrelated donor transplantation
Blood,
December 15, 2005;
106(13):
4370 - 4376.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Audige, E. Schlaepfer, H. Joller, and R. F. Speck
Uncoupled Anti-HIV and Immune-Enhancing Effects when Combining IFN-{alpha} and IL-7
J. Immunol.,
September 15, 2005;
175(6):
3724 - 3736.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Henson, R. Snelgrove, T. Hussell, D. J. Wells, and R. Aspinall
An IL-7 Fusion Protein That Shows Increased Thymopoietic Ability
J. Immunol.,
September 15, 2005;
175(6):
4112 - 4118.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. DeRyckere and J. DeGregori
E2F1 and E2F2 Are Differentially Required for Homeostasis-Driven and Antigen-Induced T Cell Proliferation In Vivo
J. Immunol.,
July 15, 2005;
175(2):
647 - 655.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Fry and C. L. Mackall
The Many Faces of IL-7: From Lymphopoiesis to Peripheral T Cell Maintenance
J. Immunol.,
June 1, 2005;
174(11):
6571 - 6576.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Higgins, J. A. Metcalf, R. A. Stevens, M. Baseler, M. C. Nason, H. C. Lane, and I. Sereti
Effects of Lymphocyte Isolation and Timing of Processing on Detection of CD127 Expression on T Cells in Human Immunodeficiency Virus-Infected Patients
Clin. Vaccine Immunol.,
January 1, 2005;
12(1):
228 - 230.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Fry, M. Sinha, M. Milliron, Y.-W. Chu, V. Kapoor, R. E. Gress, E. Thomas, and C. L. Mackall
Flt3 ligand enhances thymic-dependent and thymic-independent immune reconstitution
Blood,
November 1, 2004;
104(9):
2794 - 2800.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Moniuszko, T. Fry, W.-P. Tsai, M. Morre, B. Assouline, P. Cortez, M. G. Lewis, S. Cairns, C. Mackall, and G. Franchini
Recombinant Interleukin-7 Induces Proliferation of Naive Macaque CD4+ and CD8+ T Cells In Vivo
J. Virol.,
September 15, 2004;
78(18):
9740 - 9749.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. T Ngom, A. C Collinson, J. Pido-Lopez, S. M Henson, A. M Prentice, and R. Aspinall
Improved thymic function in exclusively breastfed infants is associated with higher interleukin 7 concentrations in their mothers' breast milk
Am. J. Clinical Nutrition,
September 1, 2004;
80(3):
722 - 728.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. C. Broers, S. J. Posthumus-van Sluijs, H. Spits, B. van der Holt, B. Lowenberg, E. Braakman, and J. J. Cornelissen
Interleukin-7 improves T-cell recovery after experimental T-cell-depleted bone marrow transplantation in T-cell-deficient mice by strong expansion of recent thymic emigrants
Blood,
August 15, 2003;
102(4):
1534 - 1540.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Jaleco, L. Swainson, V. Dardalhon, M. Burjanadze, S. Kinet, and N. Taylor
Homeostasis of Naive and Memory CD4+ T Cells: IL-2 and IL-7 Differentially Regulate the Balance Between Proliferation and Fas-Mediated Apoptosis
J. Immunol.,
July 1, 2003;
171(1):
61 - 68.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Bello-Fernandez, J. Stasakova, A. Renner, N. Carballido-Perrig, M. Koening, M. Waclavicek, O. Madjic, L. Oehler, O. Haas, J. M. Carballido, et al.
Retrovirus-mediated IL-7 expression in leukemic dendritic cells generated from primary acute myelogenous leukemias enhances their functional properties
Blood,
March 15, 2003;
101(6):
2184 - 2190.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Fry, M. Moniuszko, S. Creekmore, S. J. Donohue, D. C. Douek, S. Giardina, T. T. Hecht, B. J. Hill, K. Komschlies, J. Tomaszewski, et al.
IL-7 therapy dramatically alters peripheral T-cell homeostasis in normal and SIV-infected nonhuman primates
Blood,
March 15, 2003;
101(6):
2294 - 2299.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Dainiak, J. K. Waselenko, J. O. Armitage, T. J. MacVittie, and A. M. Farese
The Hematologist and Radiation Casualties
Hematology,
January 1, 2003;
2003(1):
473 - 496.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. D. Scripture-Adams, D. G. Brooks, Y. D. Korin, and J. A. Zack
Interleukin-7 Induces Expression of Latent Human Immunodeficiency Virus Type 1 with Minimal Effects on T-Cell Phenotype
J. Virol.,
November 13, 2002;
76(24):
13077 - 13082.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. L. Sinha, T. J. Fry, D. H. Fowler, G. Miller, and C. L. Mackall
Interleukin 7 worsens graft-versus-host disease
Blood,
September 18, 2002;
100(7):
2642 - 2649.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Min, P. A. Taylor, A. Panoskaltsis-Mortari, B. Chung, D. M. Danilenko, C. Farrell, D. L. Lacey, B. R. Blazar, and K. I. Weinberg
Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation
Blood,
May 29, 2002;
99(12):
4592 - 4600.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Fry and C. L. Mackall
Interleukin-7: from bench to clinic
Blood,
May 13, 2002;
99(11):
3892 - 3904.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Heitger, P. Winklehner, P. Obexer, J. Eder, C. Zelle-Rieser, G. Kropshofer, M. Thurnher, and W. Holter
Defective T-helper cell function after T-cell-depleting therapy affecting naive and memory populations
Blood,
May 13, 2002;
99(11):
4053 - 4062.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Steffens, E. Z. Managlia, A. Landay, and L. Al-Harthi
Interleukin-7-treated naive T cells can be productively infected by T-cell-adapted and primary isolates of human immunodeficiency virus 1
Blood,
May 1, 2002;
99(9):
3310 - 3318.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Okamoto, D. C. Douek, R. D. McFarland, and R. A. Koup
Effects of exogenous interleukin-7 on human thymus function
Blood,
April 15, 2002;
99(8):
2851 - 2858.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Franchimont, J. Galon, M. S. Vacchio, S. Fan, R. Visconti, D. M. Frucht, V. Geenen, G. P. Chrousos, J. D. Ashwell, and J. J. O'Shea
Positive Effects of Glucocorticoids on T Cell Function by Up-Regulation of IL-7 Receptor {alpha}
J. Immunol.,
March 1, 2002;
168(5):
2212 - 2218.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Fry, E. Connick, J. Falloon, M. M. Lederman, D. J. Liewehr, J. Spritzler, S. M. Steinberg, L. V. Wood, R. Yarchoan, J. Zuckerman, et al.
A potential role for interleukin-7 in T-cell homeostasis
Blood,
May 15, 2001;
97(10):
2983 - 2990.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
