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Blood, 15 March 2001, Vol. 97, No. 6, pp. 1543-1548
CHEMOKINES
CC chemokines and the receptors CCR3 and CCR5 are differentially
expressed in the nonneoplastic leukocytic infiltrates of
Hodgkin disease
Caroline Buri,
Meike Körner,
Patrik Schärli,
Daniel Cefai,
Mariagrazia Uguccioni,
Christoph Mueller,
Jean A. Laissue, and
Luca Mazzucchelli
From the Institute of Pathology and the Theodor Kocher
Institute, University of Bern, Switzerland.
Lymph nodes with Hodgkin disease (HD) harbor few neoplastic cells
in a marked leukocytic infiltrate. Since chemokines are likely to be
involved in the recruitment of these leukocytes, the expression of
potentially relevant chemokines and chemokine receptors were
studied in lymph nodes from 24 patients with HD and in 5 control lymph nodes. The expression of regulated on activation, normal
T cell expressed and secreted (RANTES), monocyte chemotactic protein (MCP)-1, macrophage inflammatory protein
(MIP)-1 , and MIP-1 was analyzed by in situ hybridization
and that of CCR3 and CCR5 by immunohistochemistry and flow cytometry.
It was found that, overall, the expression of all 4 chemokines was
markedly enhanced, but the cellular source was different. RANTES
was expressed almost exclusively by T cells whereas the expression of
MCP-1, MIP-1, and MIP-1 was confined largely to macrophages. In
control lymph nodes, chemokine expression was low, with the exception of MIP-1 in macrophages. CCR3 and CCR5 were highly expressed in T
cells of HD involved but not of control lymph nodes. CCR3 was equally
distributed in CD4+ and CD8+ cells, but CCR5
was associated largely with CD4+ cells. In HD lymph nodes,
CCR3 and CCR5 were also expressed in B cells, which normally do not
express these receptors. All these chemokines and receptors studied, by
contrast, were absent in the neoplastic cells. It was concluded that
chemokines are involved in the formation of the HD nonneoplastic
leukocytic infiltrate. Expression of CCR3 and CCR5 appears to be
characteristic of HD, but the roles of these receptors' up-regulation
for the disease process remain unclear.
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