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Blood, 15 March 2001, Vol. 97, No. 6, pp. 1803-1808
IMMUNOBIOLOGY
UVB-induced apoptosis of human dendritic cells: contribution by
caspase-dependent and caspase-independent pathways
Chiara Nicolò,
Barbara Tomassini,
Maria Rita Rippo, and
Roberto Testi
From the Laboratory of Signal Transduction, Department
of Experimental Medicine and Biochemical Sciences, University of Rome
"Tor Vergata," Italy.
Dendritic cells (DCs) play a central role in the initiation and
regulation of the immune response. The modalities by which DCs are
committed to undergo apoptosis are poorly defined. Here it is shown
that, unlike death receptor ligands, UVB radiation triggers apoptosis
of human DCs very efficiently. UVB exposure is followed by the
activation of caspases 8, 9, and 3, by the loss of mitochondrial
transmembrane potential (  m), and by cellular and nuclear
fragmentation. Caspase inhibitors substantially prevented the
occurrence of cellular and nuclear fragmentation but had no effect on
UVB-induced m dissipation. Importantly, mature DCs (MDCs)
displayed relative resistance to UVB; UVB-induced caspase activation
and apoptosis were substantially delayed compared to immature DCs
(IDCs). Resistance correlated with the strong up-regulation of cellular
FLIP and bcl2 observed in MDCs compared to IDCs.
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