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Related Collections Hematopoiesis and Stem Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 April 2001, Vol. 97, No. 7, pp. 1968-1974 HEMATOPOIESIS Erythroblasts are a source of angiogenic factors Rafaèle Tordjman, Stéphanie Delaire, Jean Plouët, Stephen Ting, Philippe Gaulard, Serge Fichelson, Paul-Henri Roméo, and Valérie Lemarchandel From Institut National de la Santé et de la Recherche Médicale (INSERM) U474, Maternité Port-Royal, and Laboratoire d'Hématopoïèse, Site Transfusionnel, Hôpital Cochin, Paris, France; INSERM U448 and Département de Pathologie EA 2348, Hôpital Mondor, Créteil, France; IPBS, GDR 1927, Centre National de la Recherche Scientifique UPR 9062, Toulouse, France. In adult bone marrow, mature erythroblasts are produced within structures called erythroblastic islands and then cross the endothelial barrier to reach circulation. Erythroblastic islands are composed of a central macrophage surrounded by maturing erythroblasts. In this study, it is shown that erythroid cells, but not the other mature hematopoietic cells, coexpress 2 angiogenic factors, vascular endothelial growth factor A (VEGF-A) and placenta growth factor (PlGF). Secretion of both VEGF-A and PlGF increases during in vitro erythroid differentiation. Erythroblast-conditioned medium can induce both migration of monocytes and endothelial cells and the permeability of endothelial cells. These effects are inhibited by anti-PlGF and/or anti-VEGF antibodies. Finally, it is shown that VEGF-A and PlGF proteins are expressed by bone marrow erythroblasts in vivo. Angiogenic factors secreted by erythroblasts may promote interactions either with macrophages in erythroblastic islands or with endothelial cells that would facilitate the passage of erythroid cells through the endothelial barrier. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: N. Patel, C. S. Gonsalves, M. Yang, P. Malik, and V. K. Kalra Placenta growth factor induces 5-lipoxygenase-activating protein to increase leukotriene formation in sickle cell disease Blood, January 29, 2009; 113(5): 1129 - 1138. [Abstract] [Full Text] [PDF] M. J. Telen It really IS the red cell Blood, August 1, 2008; 112(3): 459 - 460. [Full Text] [PDF] J. A. Chasis and N. Mohandas Erythroblastic islands: niches for erythropoiesis Blood, August 1, 2008; 112(3): 470 - 478. [Abstract] [Full Text] [PDF] N. Patel, C. S. Gonsalves, P. Malik, and V. K. 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	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020