|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 April 2001, Vol. 97, No. 7, pp. 2137-2144
NEOPLASIA
Human T-cell leukemia virus type I oncoprotein Tax represses
Smad-dependent transforming growth factor  signaling through
interaction with CREB-binding protein/p300
Naoki Mori,
Mariko Morishita,
Tomoo Tsukazaki,
Chou-Zen Giam,
Atsushi Kumatori,
Yuetsu Tanaka, and
Naoki Yamamoto
From the Department of Preventive Medicine and AIDS
Research and the Department of Biochemistry, Institute of Tropical
Medicine, Nagasaki University; the Departments of Anatomy and Surgery
II, Nagasaki University School of Medicine, Japan; the Department of
Infectious Disease and Immunology, Okinawa-Asia Research Center of
Medical Science, Faculty of Medicine, University of the Ryukyus,
Nishihara, Okinawa, Japan; and the Department of Microbiology and
Immunology, Uniformed Services University of the Health Sciences,
Bethesda, MD.
Human T-cell leukemia virus type I (HTLV-I) Tax is a potent
transcriptional regulator that can activate or repress specific cellular genes and that has been proposed to contribute to
leukemogenesis in adult T-cell leukemia. Previously,
HTLV-I- infected T-cell clones were found to be resistant to growth
inhibition by transforming growth factor (TGF)- . Here it is shown
that Tax can perturb Smad-dependent TGF- signaling even though no
direct interaction of Tax and Smad proteins could be detected.
Importantly, a mutant Tax of CREB-binding protein (CBP)/p300 binding
site, could not repress the Smad transactivation function, suggesting
that the CBP/p300 binding domain of Tax is essential for the
suppression of Smad function. Because both Tax and Smad are known to
interact with CBP/p300 for the potentiation of their transcriptional
activities, the effect of CBP/p300 on suppression of Smad-mediated
transactivation by Tax was examined. Overexpression of CBP/p300
reversed Tax-mediated inhibition of Smad transactivation. Furthermore,
Smad could repress Tax transcriptional activation, indicating
reciprocal repression between Tax and Smad. These results suggest that
Tax interferes with the recruitment of CBP/p300 into transcription
initiation complexes on TGF--responsive elements through its
binding to CBP/p300. The novel function of Tax as a repressor of
TGF- signaling may contribute to HTLV-I leukemogenesis.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
C. Grant, U. Oh, K. Yao, Y. Yamano, and S. Jacobson
Dysregulation of TGF-{beta} signaling and regulatory and effector T-cell function in virus-induced neuroinflammatory disease
Blood,
June 15, 2008;
111(12):
5601 - 5609.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. L. Di Bartolo, M. Cannon, Y.-F. Liu, R. Renne, A. Chadburn, C. Boshoff, and E. Cesarman
KSHV LANA inhibits TGF-{beta} signaling through epigenetic silencing of the TGF-{beta} type II receptor
Blood,
May 1, 2008;
111(9):
4731 - 4740.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Datta, M. Bellon, U. Sinha-Datta, A. Bazarbachi, Y. Lepelletier, D. Canioni, T. A. Waldmann, O. Hermine, and C. Nicot
Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence
Blood,
August 1, 2006;
108(3):
1021 - 1029.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Dong and G. C. Blobe
Role of transforming growth factor-beta in hematologic malignancies
Blood,
June 15, 2006;
107(12):
4589 - 4596.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Tabakin-Fix, I. Azran, Y. Schavinky-Khrapunsky, O. Levy, and M. Aboud
Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: mechanisms and clinical implications
Carcinogenesis,
April 1, 2006;
27(4):
673 - 681.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. S. Jones, S. Akel, C. Petrow-Sadowski, Y. Huang, D. C. Bertolette, and F. W. Ruscetti
Induction of Human T Cell Leukemia Virus Type I Receptors on Quiescent Naive T Lymphocytes by TGF-{beta}
J. Immunol.,
April 1, 2005;
174(7):
4262 - 4270.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Yoshida, K. Nosaka, J.-i. Yasunaga, I. Nishikata, K. Morishita, and M. Matsuoka
Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells
Blood,
April 1, 2004;
103(7):
2753 - 2760.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-C. Twizere, V. Kruys, L. Lefebvre, A. Vanderplasschen, D. Collete, C. Debacq, W. S. Lai, J.-C. Jauniaux, L. R. Bernstein, O. J. Semmes, et al.
Interaction of Retroviral Tax Oncoproteins With Tristetraprolin and Regulation of Tumor Necrosis Factor-{alpha} Expression
J Natl Cancer Inst,
December 17, 2003;
95(24):
1846 - 1859.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Sasaki, H. Suzuki, K. Yagi, M. Furuhashi, R. Yao, S. Susa, T. Noda, Y. Arai, K. Miyazono, and M. Kato
Lymphoid Enhancer Factor 1 Makes Cells Resistant to Transforming Growth Factor {beta}-induced Repression of c-myc
Cancer Res.,
February 15, 2003;
63(4):
801 - 806.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Arnulf, A. Villemain, C. Nicot, E. Mordelet, P. Charneau, J. Kersual, Y. Zermati, A. Mauviel, A. Bazarbachi, and O. Hermine
Human T-cell lymphotropic virus oncoprotein Tax represses TGF-beta 1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis
Blood,
December 1, 2002;
100(12):
4129 - 4138.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. K. Lee, B.-C. Kim, J. N. Brady, K.-T. Jeang, and S.-J. Kim
Human T-cell Lymphotropic Virus Type 1 Tax Inhibits Transforming Growth Factor-beta Signaling by Blocking the Association of Smad Proteins with Smad-binding Element
J. Biol. Chem.,
September 6, 2002;
277(37):
33766 - 33775.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
