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Blood, 1 April 2001, Vol. 97, No. 7, pp. 2171-2172

BRIEF REPORT

Autoantibodies to alpha IIbbeta 3 in patients with chronic immune thrombocytopenic purpura bind primarily to epitopes on alpha IIb

Robert McMillan, Jennifer Lopez-Dee, and Joseph C. Loftus

From the Department of Molecular and Experimental Medicine, Room 215, The Scripps Research Institute, La Jolla, CA, and the Department of Biochemistry and Molecular Biology, Mayo Clinic, Scottsdale, AZ.

Chronic immune thrombocytopenic purpura (ITP) is an autoimmune disease caused by platelet destruction resulting from autoantibodies against platelet surface proteins, particularly platelet glycoprotein IIb/IIIa (alpha IIbbeta 3). To localize the auto-epitopes on platelet alpha IIbbeta 3, the binding of autoantibodies to Chinese hamster ovary (CHO) cells expressing either alpha IIbbeta 3 or alpha vbeta 3 was studied. Thirteen of 14 ITP autoantibodies bound only to CHO cells expressing alpha IIbbeta 3. Because these 2 integrins have the same beta chain (beta 3), these results show that most epitopes in chronic ITP are dependent on the presence of glycoprotein alpha IIb.

© 2001 by The American Society of Hematology.
 

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