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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Aoki, Y. Articles by Tosato, G. Search for Related Content PubMed PubMed Citation Articles by Aoki, Y. Articles by Tosato, G. Related Collections Hematopoiesis and Stem Cells Immunobiology Neoplasia Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 April 2001, Vol. 97, No. 7, pp. 2173-2176 BRIEF REPORT Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders Yoshiyasu Aoki, Robert Yarchoan, Kathleen Wyvill, Shin-ichiro Okamoto, Richard F. Little, and Giovanna Tosato From the Medicine Branch and the HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; and the Division of Hematology, Keio University School of Medicine, Tokyo, Japan. Expression of a viral interleukin-6 (vIL-6) has been detected in certain Kaposi sarcoma (KS)-associated herpesvirus positive (KSHV+) lesions. The release of vIL-6 systemically and its contribution to the pathogenesis of HIV-related malignancies was studied. Serum vIL-6 was detected in 13 (38.2%) of 34 HIV+ patients with KS, in 6 (85.7%) of 7 HIV+ patients with primary effusion lymphoma (PEL) and/or multicentric Castleman disease (MCD), and in 18 (60.0%) of 30 HIV+, mostly homosexual, individuals without KS, MCD, or PEL. By contrast, serum vIL-6 was detected in only 3 (23.1%) of 13 patients with classic KS, 1 (2.5%) of 40 blood donors from the United States, and 4 (19.0%) of 21 blood donors from Italy. Circulating vIL-6 levels were associated with HIV+ status (P < .0001). However, within the HIV+ cohort, serum vIL-6 levels were not associated with the occurrence of KSHV-associated malignancies (P = .43). © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M-Q Du, C M Bacon, and P G Isaacson Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and lymphoproliferative disorders J. Clin. Pathol., December 1, 2007; 60(12): 1350 - 1357. [Abstract] [Full Text] [PDF] D. Chen and J. Nicholas Structural Requirements for gp80 Independence of Human Herpesvirus 8 Interleukin-6 (vIL-6) and Evidence for gp80 Stabilization of gp130 Signaling Complexes Induced by vIL-6 J. Virol., October 1, 2006; 80(19): 9811 - 9821. [Abstract] [Full Text] [PDF] W. H. Navarro and L. D. Kaplan AIDS-related lymphoproliferative disease Blood, January 1, 2006; 107(1): 13 - 20. [Abstract] [Full Text] [PDF] O. Prakash, O. R. Swamy, X. Peng, Z.-Y. Tang, L. Li, J. E. Larson, J. C. Cohen, J. Gill, G. Farr, S. Wang, et al. Activation of Src kinase Lyn by the Kaposi sarcoma-associated herpesvirus K1 protein: implications for lymphomagenesis Blood, May 15, 2005; 105(10): 3987 - 3994. [Abstract] [Full Text] [PDF] M. B. Meads and P. G. Medveczky Kaposi's Sarcoma-associated Herpesvirus-encoded Viral Interleukin-6 Is Secreted and Modified Differently Than Human Interleukin-6: EVIDENCE FOR A UNIQUE AUTOCRINE SIGNALING MECHANISM J. Biol. Chem., December 10, 2004; 279(50): 51793 - 51803. [Abstract] [Full Text] [PDF] H. Deng, J. T. Chu, M. B. Rettig, O. Martinez-Maza, and R. Sun Rta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression Blood, August 13, 2002; 100(5): 1919 - 1921. [Abstract] [Full Text] [PDF] J. An, A. K. Lichtenstein, G. Brent, and M. B. Rettig The Kaposi sarcoma-associated herpesvirus (KSHV) induces cellular interleukin 6 expression: role of the KSHV latency-associated nuclear antigen and the AP1 response element Blood, January 15, 2002; 99(2): 649 - 654. [Abstract] [Full Text] [PDF] Y. Aoki, M. Narazaki, T. Kishimoto, and G. Tosato Receptor engagement by viral interleukin-6 encoded by Kaposi sarcoma-associated herpesvirus Blood, November 15, 2001; 98(10): 3042 - 3049. [Abstract] [Full Text] [PDF] M. Zheng, S. Deshpande, S. Lee, N. Ferrara, and B. T. Rouse Contribution of Vascular Endothelial Growth Factor in the Neovascularization Process during the Pathogenesis of Herpetic Stromal Keratitis J. Virol., October 15, 2001; 75(20): 9828 - 9835. [Abstract] [Full Text] [PDF] Y. Aoki, G. Tosato, T. W. Fonville, and S. Pittaluga Serum viral interleukin-6 in AIDS-related multicentric Castleman disease Blood, April 15, 2001; 97(8): 2526 - 2527. [Full Text] [PDF]

	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020