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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Nilsson, S. K. Articles by Coverdale, J. A. Search for Related Content PubMed PubMed Citation Articles by Nilsson, S. K. Articles by Coverdale, J. A. Related Collections Hematopoiesis and Stem Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 April 2001, Vol. 97, No. 8, pp. 2293-2299 HEMATOPOIESIS Spatial localization of transplanted hemopoietic stem cells: inferences for the localization of stem cell niches Susan K. Nilsson, Hayley M. Johnston, and Judi A. Coverdale From the Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia. The spatial distribution of subpopulations of hemopoietic progenitor cells following syngeneic transplantation was investigated at the single-cell level. The location of infused hemopoietic progenitor cells within the femoral bone marrow of nonablated recipients was determined by 5-(and-6)-carboxyfluorescein diacetate succinimidyl ester labeling of cells and in situ fixation by perfusion. Analysis performed over 15 hours after infusion demonstrated that the spatial distribution of transplanted marrow cells is not a random process. Although the majority of cells enter the bone marrow from the central marrow vessels, the subsequent localization within the bone marrow varied according to their phenotype. Candidate "stem cells" demonstrated selective redistribution and were significantly enriched within the endosteal region, whereas mature terminally differentiated and lineage-committed cells selectively redistributed away from the endosteal region and were predominantly in the central marrow region. Together, these data strongly support historical evidence of the presence of endosteal hemopoietic stem cell niches. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. Jiang, H. Bonig, T. Ulyanova, K. Chang, and T. Papayannopoulou On the adaptation of endosteal stem cell niche function in response to stress Blood, October 29, 2009; 114(18): 3773 - 3782. [Abstract] [Full Text] [PDF] R. Sugimura and L. Li Shifting in Balance Between Osteogenesis and Adipogenesis Substantially Influences Hematopoiesis J Mol Cell Biol, October 14, 2009; (2009) mjp030v1. 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	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020