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Blood, 1 May 2001, Vol. 97, No. 9, pp. 2541-2548
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
Experiences of donors enrolled in a randomized study of
allogeneic bone marrow or peripheral blood stem cell
transplantation
Scott D. Rowley,
Gary Donaldson,
Kathy Lilleby,
William I. Bensinger, and
Frederick R. Appelbaum
From the Clinical Research Division, Fred Hutchinson
Cancer Research Center, Seattle, WA.
The experiences of 69 (38 marrow and 31 peripheral blood stem cell
[PBSC]) donors participating in a randomized trial comparing allogeneic bone marrow with PBSC transplantation were studied. Marrow
was collected by means of standard harvest techniques and general or
regional anesthesia. PBSC donors were treated with 5 to 7 days of
filgrastim at a dose of 16 µg/kg/d and underwent 1 to 3 days of
apheresis to obtain 5 × 106 CD34+ cells per
kilogram recipient weight. Donors completed questionnaires describing
their health experiences before, during, and then weekly after donation
until return to baseline status. Both marrow and PBSC donors reported
minimal fluctuation in symptoms measuring emotional status. In
contrast, both groups of donors reported deterioration in physical
status starting with administration of filgrastim (PBSC donors) or
after the marrow collection procedure. The symptom burden reported was
similar, with pain a prominent symptom for both groups. Equivalent mean
levels of maximal pain, average pain, and pain duration through the day
were reported, although toxicity peaks occurred at different time
points during the harvest procedures. All PBSC donors but only 79% of
marrow donors reported good physical status by 14 days after the
harvest procedures. These data demonstrate similar levels of physical discomfort for hematopoietic stem cell donors regardless of the collection procedure used, but a quicker resolution of symptoms for
PBSC donors.
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