|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 May 2001, Vol. 97, No. 9, pp. 2777-2783
NEOPLASIA
Survivin is expressed on CD40 stimulation and interfaces
proliferation and apoptosis in B-cell chronic lymphocytic
leukemia
Luisa Granziero,
Paolo Ghia,
Paola Circosta,
Daniela Gottardi,
Giuliana Strola,
Massimo Geuna,
Licia Montagna,
Paola Piccoli,
Marco Chilosi, and
Federico Caligaris-Cappio
From the Department of Biomedical Sciences and Human
Oncology, University of Torino, Italy; IRCC, Institute for Cancer
Research and Treatment, Candiolo, Italy; and University Division of
Clinical Immunology and Hematology, Ospedale Mauriziano Umberto I,
Torino, Italy; and the Department of Pathology, University of Verona,
Policlinico Borgo Roma, Italy.
In B-cell chronic lymphocytic leukemia (B-CLL), defective apoptosis
causes the accumulation of mature CD5+ B cells in lymphoid
organs, bone marrow (BM), and peripheral blood (PB). These cells are
the progeny of a proliferating pool that feeds the accumulating
compartment. The authors sought to determine which molecular mechanisms
govern the proliferating pool, how they relate to apoptosis, and what
the role is of the microenvironment. To begin to resolve these
problems, the expression and modulation of the family of inhibitor of
apoptosis proteins (IAPs) were investigated, with consideration given
to the possibility that physiological stimuli, such as CD40 ligand
(CD40L), available to B cells in the microenvironment, might modulate
IAP expression. The in vitro data on mononuclear cells from PB or BM of
30 patients demonstrate that B-CLL cells on CD40 stimulation express
Survivin and that Survivin is the only IAP whose expression is induced by CD40L. Through immunohistochemistry, in vivo Survivin expression in
lymph node (LN) and BM biopsies was evaluated. In reactive LN, Survivin
was detected only in highly proliferating germinal center cells. In LN
from patients with B-CLL, Survivin was detected only in
pseudofollicles. Pseudofollicle Survivin+ cells were
actively proliferating and, in contrast to Survivin+ B
cells found in normal GC, were Bcl-2+. In B-CLL BM
biopsies, CD5+, Survivin+ cells were observed
in clusters interspersed with T cells. These findings establish that
Survivin controls the B-CLL proliferative pool interfacing apoptosis
and that its expression may be modulated by microenvironmental stimuli.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
P. E. M. Patten, A. G. S. Buggins, J. Richards, A. Wotherspoon, J. Salisbury, G. J. Mufti, T. J. Hamblin, and S. Devereux
CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment
Blood,
May 15, 2008;
111(10):
5173 - 5181.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Secchiero, E. Melloni, M. Tiribelli, A. Gonelli, and G. Zauli
Combined treatment of CpG-oligodeoxynucleotide with Nutlin-3 induces strong immune stimulation coupled to cytotoxicity in B-chronic lymphocytic leukemic (B-CLL) cells
J. Leukoc. Biol.,
February 1, 2008;
83(2):
434 - 437.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. de Totero, R. Meazza, M. Capaia, M. Fabbi, B. Azzarone, E. Balleari, M. Gobbi, G. Cutrona, M. Ferrarini, and S. Ferrini
The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways
Blood,
January 15, 2008;
111(2):
517 - 524.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. N. Damle, S. Temburni, C. Calissano, S. Yancopoulos, T. Banapour, C. Sison, S. L. Allen, K. R. Rai, and N. Chiorazzi
CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells
Blood,
November 1, 2007;
110(9):
3352 - 3359.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. P. Kater, M. H. J. van Oers, and T. J. Kipps
Cellular immune therapy for chronic lymphocytic leukemia
Blood,
October 15, 2007;
110(8):
2811 - 2818.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Durig, P. Ebeling, F. Grabellus, U. R. Sorg, M. Mollmann, P. Schutt, J. Gothert, L. Sellmann, S. Seeber, M. Flasshove, et al.
A Novel Nonobese Diabetic/Severe Combined Immunodeficient Xenograft Model for Chronic Lymphocytic Leukemia Reflects Important Clinical Characteristics of the Disease
Cancer Res.,
September 15, 2007;
67(18):
8653 - 8661.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Troeger, M. Siepermann, G. Escherich, R. Meisel, R. Willers, S. Gudowius, T. Moritz, H.-J. Laws, H. Hanenberg, U. Goebel, et al.
Survivin and its prognostic significance in pediatric acute B-cell precursor lymphoblastic leukemia
Haematologica,
August 1, 2007;
92(8):
1043 - 1050.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. D. Mineva, T. L. Rothstein, J. A. Meyers, A. Lerner, and G. E. Sonenshein
CD40 Ligand-mediated Activation of the de Novo RelB NF-{kappa}B Synthesis Pathway in Transformed B Cells Promotes Rescue from Apoptosis
J. Biol. Chem.,
June 15, 2007;
282(24):
17475 - 17485.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. H. Vonderheide
Prospect of Targeting the CD40 Pathway for Cancer Therapy
Clin. Cancer Res.,
February 15, 2007;
13(4):
1083 - 1088.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. A. Smit, D. Y.H. Hallaert, R. Spijker, B. de Goeij, A. Jaspers, A. P. Kater, M. H.J. van Oers, C. J.M. van Noesel, and E. Eldering
Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity
Blood,
February 15, 2007;
109(4):
1660 - 1668.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Fukuda and L. M. Pelus
Survivin, a cancer target with an emerging role in normal adult tissues
Mol. Cancer Ther.,
May 1, 2006;
5(5):
1087 - 1098.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. J. Richardson, C. Matthews, M. A. Catherwood, H. D. Alexander, B. S. Carey, J. Farrugia, A. Gardiner, S. Mould, D. Oscier, J. A. Copplestone, et al.
ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL)
Blood,
May 1, 2006;
107(9):
3584 - 3592.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Chiorazzi and M. Ferrarini
Evolving View of the In-Vivo Kinetics of Chronic Lymphocytic Leukemia B Cells
Hematology,
January 1, 2006;
2006(1):
273 - 278.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. P. Kater, F. Dicker, M. Mangiola, K. Welsh, R. Houghten, J. Ostresh, A. Nefzi, J. C. Reed, C. Pinilla, and T. J. Kipps
Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis
Blood,
September 1, 2005;
106(5):
1742 - 1748.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Dicker, A. P. Kater, T. Fukuda, and T. J. Kipps
Fas-ligand (CD178) and TRAIL synergistically induce apoptosis of CD40-activated chronic lymphocytic leukemia B cells
Blood,
April 15, 2005;
105(8):
3193 - 3198.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Nedellec, Y. Renaudineau, A. Bordron, C. Berthou, N. Porakishvili, P. M. Lydyard, J.-O. Pers, and P. Youinou
B Cell Response to Surface IgM Cross-Linking Identifies Different Prognostic Groups of B-Chronic Lymphocytic Leukemia Patients
J. Immunol.,
March 15, 2005;
174(6):
3749 - 3756.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Chiorazzi, K. R. Rai, and M. Ferrarini
Chronic Lymphocytic Leukemia
N. Engl. J. Med.,
February 24, 2005;
352(8):
804 - 815.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Idenoue, Y. Hirohashi, T. Torigoe, Y. Sato, Y. Tamura, H. Hariu, M. Yamamoto, T. Kurotaki, T. Tsuruma, H. Asanuma, et al.
A Potent Immunogenic General Cancer Vaccine That Targets Survivin, an Inhibitor of Apoptosis Proteins
Clin. Cancer Res.,
February 15, 2005;
11(4):
1474 - 1482.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. Gricks, D. Zahrieh, A. J. Zauls, G. Gorgun, D. Drandi, K. Mauerer, D. Neuberg, and J. G. Gribben
Differential regulation of gene expression following CD40 activation of leukemic compared to healthy B cells
Blood,
December 15, 2004;
104(13):
4002 - 4009.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Rodriguez, N. Martinez, F. I. Camacho, E. Ruiz-Ballesteros, P. Algara, J.-F. Garcia, J. Menarguez, T. Alvaro, M. F. Fresno, F. Solano, et al.
Variability in the Degree of Expression of Phosphorylated I{kappa}B{alpha} in Chronic Lymphocytic Leukemia Cases With Nodal Involvement
Clin. Cancer Res.,
October 15, 2004;
10(20):
6796 - 6806.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. K. Stevenson and F. Caligaris-Cappio
Chronic lymphocytic leukemia: revelations from the B-cell receptor
Blood,
June 15, 2004;
103(12):
4389 - 4395.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. R. Muller, G. Tsakou, F. Grunebach, S. M. Schmidt, and P. Brossart
Induction of chronic lymphocytic leukemia (CLL)-specific CD4- and CD8-mediated T-cell responses using RNA-transfected dendritic cells
Blood,
March 1, 2004;
103(5):
1763 - 1769.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Martinez, B. Bellosillo, F. Bosch, A. Ferrer, S. Marce, N. Villamor, G. Ott, E. Montserrat, E. Campo, and D. Colomer
Nuclear Survivin Expression in Mantle Cell Lymphoma Is Associated with Cell Proliferation and Survival
Am. J. Pathol.,
February 1, 2004;
164(2):
501 - 510.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Younes and M. E. Kadin
Emerging Applications of the Tumor Necrosis Factor Family of Ligands and Receptors in Cancer Therapy
J. Clin. Oncol.,
September 15, 2003;
21(18):
3526 - 3534.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Deaglio, A. Capobianco, L. Bergui, J. Durig, F. Morabito, U. Duhrsen, and F. Malavasi
CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells
Blood,
September 15, 2003;
102(6):
2146 - 2155.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Greil, G. Anether, K. Johrer, and I. Tinhofer
Tracking death dealing by Fas and TRAIL in lymphatic neoplastic disorders: pathways, targets, and therapeutic tools
J. Leukoc. Biol.,
September 1, 2003;
74(3):
311 - 330.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Paydas, K. Tanriverdi, S. Yavuz, U. Disel, B. Sahin, and R. Burgut
Survivin and aven: two distinct antiapoptotic signals in acute leukemias
Ann. Onc.,
July 1, 2003;
14(7):
1045 - 1050.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. F. Jelinek, R. C. Tschumper, G. A. Stolovitzky, S. J. Iturria, Y. Tu, J. Lepre, N. Shah, and N. E. Kay
Identification of a Global Gene Expression Signature of B-Chronic Lymphocytic Leukemia
Mol. Cancer Res.,
March 1, 2003;
1(5):
346 - 361.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Granziero, P. Circosta, C. Scielzo, E. Frisaldi, S. Stella, M. Geuna, S. Giordano, P. Ghia, and F. Caligaris-Cappio
CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes
Blood,
March 1, 2003;
101(5):
1962 - 1969.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Ghia, G. Guida, S. Stella, D. Gottardi, M. Geuna, G. Strola, C. Scielzo, and F. Caligaris-Cappio
The pattern of CD38 expression defines a distinct subset of chronic lymphocytic leukemia (CLL) patients at risk of disease progression
Blood,
February 15, 2003;
101(4):
1262 - 1269.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Lanham, T. Hamblin, D. Oscier, R. Ibbotson, F. Stevenson, and G. Packham
Differential signaling via surface IgM is associated with VH gene mutational status and CD38 expression in chronic lymphocytic leukemia
Blood,
February 1, 2003;
101(3):
1087 - 1093.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Decker, S. Hipp, I. Ringshausen, C. Bogner, M. Oelsner, F. Schneller, and C. Peschel
Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin
Blood,
January 1, 2003;
101(1):
278 - 285.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Cerutti, H. Zan, E. C. Kim, S. Shah, E. J. Schattner, A. Schaffer, and P. Casali
Ongoing In Vivo Immunoglobulin Class Switch DNA Recombination in Chronic Lymphocytic Leukemia B Cells
J. Immunol.,
December 1, 2002;
169(11):
6594 - 6603.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Munzert, D. Kirchner, H. Stobbe, L. Bergmann, R. M. Schmid, H. Dohner, and H. Heimpel
Tumor necrosis factor receptor-associated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: analysis of NF-kappa B/Rel-regulated inhibitors of apoptosis
Blood,
November 15, 2002;
100(10):
3749 - 3756.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Fukuda, R. G. Foster, S. B. Porter, and L. M. Pelus
The antiapoptosis protein survivin is associated with cell cycle entry of normal cord blood CD34+ cells and modulates cell cycle and proliferation of mouse hematopoietic progenitor cells
Blood,
September 18, 2002;
100(7):
2463 - 2471.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C.-M. Wendtner, D. M. Kofler, H. D. Theiss, C. Kurzeder, R. Buhmann, C. Schweighofer, L. Perabo, S. Danhauser-Riedl, J. Baumert, W. Hiddemann, et al.
Efficient gene transfer of CD40 ligand into primary B-CLL cells using recombinant adeno-associated virus (rAAV) vectors
Blood,
August 13, 2002;
100(5):
1655 - 1661.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. V. Potapov, H. R. Zurbrugg, C. Herzke, S. Srock, H. Riess, R. Sodian, S. Hubler, and R. Hetzer
Impact of cardiac surgery using cardiopulmonary bypass on course of chronic lymphatic leukemia: a case-control study
Ann. Thorac. Surg.,
August 1, 2002;
74(2):
384 - 389.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. E. Kay, T. J. Hamblin, D. F. Jelinek, G. W. Dewald, J. C. Byrd, S. Farag, M. Lucas, and T. Lin
Chronic Lymphocytic Leukemia
Hematology,
January 1, 2002;
2002(1):
193 - 213.
[Abstract]
[Full Text]
|
|
|
| |
