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Related Collections Neoplasia Cell Cycle Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 July 2001, Vol. 98, No. 1, pp. 244-246 BRIEF REPORT p16INK4a and p15INK4b gene methylations in plasma cells from monoclonal gammopathy of undetermined significance Gaëlle Guillerm, Emmanuel Gyan, Darius Wolowiec, Thierry Facon, Hervé Avet-Loiseau, Kazimierz Kuliczkowski, Francis Bauters, Pierre Fenaux, and Bruno Quesnel From the Unité Institut National de la Santé et de la Recherche Médicale 524, Institut de Recherche sur le Cancer de Lille (IRCL), and the Service des Maladies du Sang, Centre Hospitalier et Universitaire (CHU) Lille, Lille, France; the Department of Hematology, Wroclaw Medical University, Wroclaw, Poland; and the Laboratoire d'Hématologie, CHU Nantes, Nantes, France. p15INK4b and p16INK4a proteins are cell cycle regulators involved in the inhibition of G1 phase progression. High frequency of methylation of both genes has been reported in multiple myeloma (MM), but it remains to be determined how and when these alterations contribute to tumorigenesis. Monoclonal gammopathy of undetermined significance (MGUS) represents an early disease stage in a fraction of MMs. Plasma cells from 33 patients with MGUS and 33 patients with MM were isolated and analyzed for p15INK4b and p16INK4a methylation by methylation-specific polymerase chain reaction. Selective methylation was found in 19% for p16INK4a, 36% for p15INK4b, and 6.5% for both genes in MGUS, and frequencies were similar in MM suggesting that methylation of these genes is an early event, not associated with transition from MGUS to MM. p15INK4b and p16INK4a gene methylation might contribute to immortalization of plasma cells rather than malignant transformation in the natural history of MM. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Khong, J. Sharkey, and A. Spencer The effect of azacitidine on interleukin-6 signaling and nuclear factor-{kappa}B activation and its in vitro and in vivo activity against multiple myeloma Haematologica, June 1, 2008; 93(6): 860 - 869. [Abstract] [Full Text] [PDF] A. Dib, B. Barlogie, J. D. Shaughnessy Jr, and W. M. 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	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020