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Blood, 15 November 2001, Vol. 98, No. 10, pp. 2900-2908
REVIEW ARTICLE
Peripheral blood stem cell versus bone marrow
allotransplantation: does the source of hematopoietic stem cells
matter?
Martin Körbling and
Paolo Anderlini
From the Department of Blood and Marrow
Transplantation, University of Texas MD Anderson Cancer Center,
Houston.
Hematopoietic stem cells from 4 different sources have been or are
being used for the reconstitution of lymphohematopoietic function after
myeloablative, near-myeloablative, or nonmyeloablative treatment. Bone
marrow (BM)-derived stem cells, introduced by E. D. Thomas in
1963,1 are considered the classical stem cell source.
Fetal liver stem cell transplantation has been performed on a limited
number of patients with aplastic anemia or acute leukemia, but only
transient engraftment has been demonstrated.2 Peripheral
blood as a stem cell source was introduced in 1981,3 and
cord blood was introduced as a source in 1988.4 The
various stem cell sources differ in their reconstitutive and
immunogenic characteristics, which are based on the proportion of early
pluripotent and self-renewing stem cells to lineage-committed late
progenitor cells and on the number and characteristics of accompanying
"accessory cells" contained in stem cell allografts.

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