|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 November 2001, Vol. 98, No. 10, pp. 2966-2972
HEMATOPOIESIS
Age- and stage-specific regulation patterns in the
hematopoietic stem cell hierarchy
Hartmut Geiger,
Jarrod M. True,
Gerald de
Haan, and
Gary Van
Zant
From the Division of Hematology/Oncology, Departments
of Internal Medicine and Physiology, University of Kentucky Medical
Center, Lexington, KY, and the Department of Stem Cell Biology,
University of Groningen, Groningen, The Netherlands.
The molecular mechanisms that regulate self-renewal and
differentiation of very primitive hematopoietic stem and progenitor cells in vivo are still poorly understood. Despite the clinical relevance, even less is known about the mechanisms that regulate these
cells in old animals. In a forward genetic approach, using quantitative
trait linkage analysis in the mouse BXD recombinant inbred set, this
study identified loci that regulate the genetic variation in the size
of primitive hematopoietic cell compartments of young and old C57BL6
and DBA/2 animals. Linked loci were confirmed through the generation
and analysis of congenic animals. In addition, a comparative linkage
analysis revealed that the number of primitive hematopoietic cells and
hematopoietic stem cells are regulated in a stage-specific and an
age-specific manner.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
R. H. Cho, H. B. Sieburg, and C. E. Muller-Sieburg
A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells
Blood,
June 15, 2008;
111(12):
5553 - 5561.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Daria, M.-D. Filippi, E. S. Knudsen, R. Faccio, Z. Li, T. Kalfa, and H. Geiger
The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress
Blood,
February 15, 2008;
111(4):
1894 - 1902.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M Jawad, G Giotopoulos, C Cole, and M Plumb
Target cell frequency is a genetically determined risk factor in radiation leukaemogenesis
Br. J. Radiol.,
September 1, 2007;
80(Special_Issue_1):
S56 - S62.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Jawad, C. H. Seedhouse, N. Russell, and M. Plumb
Polymorphisms in human homeobox HLX1 and DNA repair RAD51 genes increase the risk of therapy-related acute myeloid leukemia
Blood,
December 1, 2006;
108(12):
3916 - 3918.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Xing, M. A. Ryan, D. Daria, K. J. Nattamai, G. Van Zant, L. Wang, Y. Zheng, and H. Geiger
Increased hematopoietic stem cell mobilization in aged mice
Blood,
October 1, 2006;
108(7):
2190 - 2197.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Fuller
Stem cell aging and cancer.
Sci. Aging Knowl. Environ.,
May 15, 2006;
2006(9):
pe12 - pe12.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Y. Liang, G. Van Zant, and S. J. Szilvassy
Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells
Blood,
August 15, 2005;
106(4):
1479 - 1487.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Geiger, G. Rennebeck, and G. Van Zant
Regulation of hematopoietic stem cell aging in vivo by a distinct genetic element
PNAS,
April 5, 2005;
102(14):
5102 - 5107.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. M. Chilton, F. Rezzoug, M. Z. Ratajczak, I. Fugier-Vivier, J. Ratajczak, M. Kucia, Y. Huang, M. K. Tanner, and S. T. Ildstad
Hematopoietic stem cells from NOD mice exhibit autonomous behavior and a competitive advantage in allogeneic recipients
Blood,
March 1, 2005;
105(5):
2189 - 2197.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Couldrey, H. L. Bradley, and K. D. Bunting
A STAT5 modifier locus on murine chromosome 7 modulates engraftment of hematopoietic stem cells during steady-state hematopoiesis
Blood,
February 15, 2005;
105(4):
1476 - 1483.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Henckaerts, J. C. Langer, J. Orenstein, and H.-W. Snoeck
The Positive Regulatory Effect of TGF-{beta}2 on Primitive Murine Hemopoietic Stem and Progenitor Cells Is Dependent on Age, Genetic Background, and Serum Factors
J. Immunol.,
August 15, 2004;
173(4):
2486 - 2493.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Henckaerts, J. C. Langer, and H.-W. Snoeck
Quantitative genetic variation in the hematopoietic stem cell and progenitor cell compartment and in lifespan are closely linked at multiple loci in BXD recombinant inbred mice
Blood,
July 15, 2004;
104(2):
374 - 379.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Abe, G. Lauby, C. Boyer, L. Manouilova, S. I. Rennard, and J. G. Sharp
Lung Cells Transplanted to Irradiated Recipients Generate Lymphohematopoietic Progeny
Am. J. Respir. Cell Mol. Biol.,
April 1, 2004;
30(4):
491 - 499.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Langer, E. Henckaerts, J. Orenstein, and H.-W. Snoeck
Quantitative Trait Analysis Reveals Transforming Growth Factor-{beta}2 as a Positive Regulator of Early Hematopoietic Progenitor and Stem Cell Function
J. Exp. Med.,
January 5, 2004;
199(1):
5 - 14.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Henckaerts, H. Geiger, J. C. Langer, P. Rebollo, G. Van Zant, and H.-W. Snoeck
Genetically determined variation in the number of phenotypically defined hematopoietic progenitor and stem cells and in their response to early-acting cytokines
Blood,
May 13, 2002;
99(11):
3947 - 3954.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
