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Related Collections Neoplasia Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 November 2001, Vol. 98, No. 10, pp. 3074-3081 NEOPLASIA Chronic myeloid leukemia and interferon-: a study of complete cytogenetic responders Francesca Bonifazi, Antonio de Vivo, Gianantonio Rosti, François Guilhot, Joëlle Guilhot, Elena Trabacchi, Rüdiger Hehlmann, Andreas Hochhaus, Patricia C. A. Shepherd, Juan Luis Steegmann, Hanneke C. Kluin-Nelemans, Josef Thaler, Bengt Simonsson, Andries Louwagie, Josy Reiffers, François Xavier Mahon, Enrico Montefusco, Giuliana Alimena, Joerg Hasford, Sue Richards, Giuseppe Saglio, Nicoletta Testoni, Giovanni Martinelli, Sante Tura, and Michele Baccarani for the European Study Group on Interferon in Chronic Myeloid Leukemia From the Study and Report Committee of the European Study Group on Interferon in Chronic Myeloid Leukemia, on behalf of the Italian Cooperative Study Group on CML, the France Intergroup of CML, the German CML Study Group, the UK Medical Research Council Working Party on CML, the Spanish CML Study Group, the Benelux CML Study Group, the Austrian CML Study Group, and the Swedish CML Study Group. Achieving a complete cytogenetic response (CCgR) is a major target in the treatment of chronic myeloid leukemia (CML) with interferon- (IFN-), but CCgRs are rare. The mean CCgR rate is 13%, in a range of 5% to 33%. A collaborative study of 9 European Union countries has led to the collection of data on 317 patients who were first seen between 1983 and 1997 and achieved CCgRs with IFN- alone or in combination with hydroxyurea. The median time to first CCgR was 19 months (95% CI, 17-21; range, 3-84 months). At last contact, 212 patients were still alive and in continuous CCgR; 105 patients had lost CCgR, but 53% of them were still alive and in chronic phase. IFN- treatment was discontinued permanently in 23 cases for response loss, in 36 cases for chronic toxicity (15 are still in unmaintained continuous CCgR), and in 8 cases because it was believed that treatment was no longer necessary (7 of these 8 patients are still in unmaintained continuous CCgR). The 10-year survival rate from first CCgR is 72% (95% CI, 62%-82%) and is related to the risk profile. High-risk patients lost CCgR more frequently and more rapidly and none survived more than 10 years. Low-risk patients survived much longer (10-year survival probability 89% for Sokal low risk and 81% for Euro low risk). These data point out that a substantial long-term survival in CCgRs is restricted mainly to low-risk and possibly intermediate-risk patients and occurs significantly less often in high-risk patients. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: V. Nardi, O. Naveiras, M. Azam, and G. Q. Daley ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines Blood, April 16, 2009; 113(16): 3813 - 3820. [Abstract] [Full Text] [PDF] F. Castagnetti, F. Palandri, M. Amabile, N. Testoni, S. Luatti, S. Soverini, I. Iacobucci, M. Breccia, G. Rege Cambrin, F. Stagno, et al. 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