|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 November 2001, Vol. 98, No. 10, pp. 3156-3158
BRIEF REPORT
Division rate and phenotypic differences discriminate
alloreactive and nonalloreactive T cells transferred in lethally
irradiated mice
Sébastien Maury,
Benoît Salomon,
David Klatzmann, and
José L. Cohen
From the Laboratoire de Biologie et Thérapeutique
des Pathologies Immunitaires CNRS/UPMC ESA 7087, Groupe Hospitalier
Pitié-Salpêtrière, Paris, France.
After non-T-cell-depleted allogeneic hematopoietic stem cell
transplantation (HSCT), both alloreactive and homeostatic signals drive
proliferation of donor T cells. Host-reactive donor T cells, which
proliferate on alloantigen stimulation, are responsible for the
life-threatening graft-versus-host disease. Non-host-reactive donor T cells, which proliferate in response to homeostatic
signals, contribute to the beneficial peripheral T-cell reconstitution. The elimination of alloreactive T cells is a major therapeutic challenge for HSCT and would greatly benefit from their specific identification. After T-cell transfer in lymphopenic recipients, the
present results show that alloreactive T cells rapidly divided; up-regulated CD69, CD25, and CD4 molecules; and down-regulated CD62L.
In contrast, nonalloreactive T cells started to divide later and did
not up-regulate CD69, CD25, and CD4. Thus, these 2 cell populations can
be effectively discriminated. This should facilitate the specific
depletion of alloreactive T cells in allogeneic HSCT.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. Maury, C. Cordonnier, M. Kuentz, D. Klatzmann, and J. L. Cohen
Searching for factors to improve the antileukemic effect of donor lymphocyte infusion
Blood,
May 15, 2008;
111(10):
5256 - 5256.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Chakraverty, H.-S. Eom, J. Sachs, J. Buchli, P. Cotter, R. Hsu, G. Zhao, and M. Sykes
Host MHC class II+ antigen-presenting cells and CD4 cells are required for CD8-mediated graft-versus-leukemia responses following delayed donor leukocyte infusions
Blood,
September 15, 2006;
108(6):
2106 - 2113.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Chakraverty, D. Cote, J. Buchli, P. Cotter, R. Hsu, G. Zhao, T. Sachs, C. M. Pitsillides, R. Bronson, T. Means, et al.
An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues
J. Exp. Med.,
August 7, 2006;
203(8):
2021 - 2031.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Trenado, M. Sudres, Q. Tang, S. Maury, F. Charlotte, S. Gregoire, M. Bonyhadi, D. Klatzmann, B. L. Salomon, and J. L. Cohen
Ex Vivo-Expanded CD4+CD25+ Immunoregulatory T Cells Prevent Graft-versus-Host-Disease by Inhibiting Activation/Differentiation of Pathogenic T Cells
J. Immunol.,
January 15, 2006;
176(2):
1266 - 1273.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Zhang and G. G. Meadows
Chronic alcohol consumption in mice increases the proportion of peripheral memory T cells by homeostatic proliferation
J. Leukoc. Biol.,
November 1, 2005;
78(5):
1070 - 1080.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. J. Funatake, N. B. Marshall, L. B. Steppan, D. V. Mourich, and N. I. Kerkvliet
Cutting Edge: Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin Generates a Population of CD4+CD25+ Cells with Characteristics of Regulatory T Cells
J. Immunol.,
October 1, 2005;
175(7):
4184 - 4188.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Berger, C. A. Blau, M.-L. Huang, J. D. Iuliucci, D. C. Dalgarno, J. Gaschet, S. Heimfeld, T. Clackson, and S. R. Riddell
Pharmacologically regulated Fas-mediated death of adoptively transferred T cells in a nonhuman primate model
Blood,
February 15, 2004;
103(4):
1261 - 1269.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Elflein, M. Rodriguez-Palmero, T. Kerkau, and T. Hunig
Rapid recovery from T lymphopenia by CD28 superagonist therapy
Blood,
September 1, 2003;
102(5):
1764 - 1770.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. J. Hill, K. Van Gunst, and N. Sarvetnick
Th1 and Th2 Pancreatic Inflammation Differentially Affects Homing of Islet-Reactive CD4 Cells in Nonobese Diabetic Mice
J. Immunol.,
February 15, 2003;
170(4):
1649 - 1658.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. Troy and H. Shen
Cutting Edge: Homeostatic Proliferation of Peripheral T Lymphocytes Is Regulated by Clonal Competition
J. Immunol.,
January 15, 2003;
170(2):
672 - 676.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Litvinova, S. Maury, O. Boyer, S. Bruel, L. Benard, G. Boisserie, D. Klatzmann, and J. L. Cohen
Graft-versus-leukemia effect after suicide-gene-mediated control of graft-versus-host disease
Blood,
August 28, 2002;
100(6):
2020 - 2025.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Guimond, A. Balassy, M. Barrette, S. Brochu, C. Perreault, and D. C. Roy
P-glycoprotein targeting: a unique strategy to selectively eliminate immunoreactive T cells
Blood,
June 28, 2002;
100(2):
375 - 382.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
