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Articles by ANRS O86 PRIMOFERON A Study Group, Related Collections Immunobiology Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 November 2001, Vol. 98, No. 10, pp. 3169-3171 BRIEF REPORT Preferential and persistent depletion of CCR5+ T-helper lymphocytes with nonlymphoid homing potential despite early treatment of primary HIV infection Roman Krzysiek, Annick Rudent, Laurence Bouchet-Delbos, Arnaud Foussat, Claudie Boutillon, Alain Portier, Didier Ingrand, Daniel Sereni, Pierre Galanaud, Liliane Grangeot-Keros, Dominique Emilie, and the ANRS O86 PRIMOFERON A Study Group From the INSERM U131 and Service de Médecine Interne et d'Immunologie Clinique, Service de Microbiologie-Immunologie, Hôpital Antoine Béclère, Institut Paris-Sud sur les Cytokines, Clamart, France, and the Service de Médecine Interne, Hôpital Saint-Louis, Paris, France. Strains of human immunodeficiency virus (HIV) transmitted between individuals use the CCR5 coreceptor, but no preferential depletion of particular Th-lymphocyte subpopulations has been reported during primary HIV infection (PHI). In contrast, gut-associated Th lymphocytes are preferentially depleted in macaques recently infected by simian immunodeficiency virus. The expression of CCR5 and the intestinal homing receptor integrin 47 on subpopulations of Th lymphocytes was studied in 12 patients with PHI. There was a profound decrease of circulating 47+ Th lymphocytes and CCR5+ memory Th lymphocytes with nonlymphoid homing potential (CD62LCD45RO+). Unlike other Th lymphocytes, this cell population remained depleted despite early control of viral replication under antiretroviral treatment. Therefore, HIV preferentially targets a specific CCR5+ subpopulation of Th lymphocytes early during infection, inducing its persistent depletion despite treatment. Protective immunity in vivo depends on Th lymphocytes carrying homing capacity to nonlymphoid tissue, and therefore these data may explain the persistent abnormalities of immune functions in patients infected with HIV. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: P. U. Cameron, A. J. Handley, D. C. Baylis, A. E. Solomon, N. Bernard, D. F. J. Purcell, and S. R. Lewin Preferential Infection of Dendritic Cells during Human Immunodeficiency Virus Type 1 Infection of Blood Leukocytes J. Virol., March 1, 2007; 81(5): 2297 - 2306. [Abstract] [Full Text] [PDF] R. Soares, R. Foxall, A. Albuquerque, C. Cortesao, M. Garcia, R. M. M. Victorino, and A. E. Sousa Increased Frequency of Circulating CCR5+ CD4+ T Cells in Human Immunodeficiency Virus Type 2 Infection J. Virol., December 15, 2006; 80(24): 12425 - 12429. [Abstract] [Full Text] [PDF] J. J. Zaunders, S. 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	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020