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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Socolovsky, M. Articles by Lodish, H. F. Search for Related Content PubMed PubMed Citation Articles by Socolovsky, M. Articles by Lodish, H. F. Related Collections Signal Transduction Hematopoiesis and Stem Cells Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 December 2001, Vol. 98, No. 12, pp. 3261-3273 HEMATOPOIESIS Ineffective erythropoiesis in Stat5a/5b/ mice due to decreased survival of early erythroblasts Merav Socolovsky, Hyung-song Nam, Mark D. Fleming, Volker H. Haase, Carlo Brugnara, and Harvey F. Lodish From the Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA; Department of Pathology, Children's Hospital; Department of Laboratory Medicine, Children's Hospital, Harvard Medical School; Renal Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA. Erythropoietin (Epo) controls red cell production in the basal state and during stress. Epo binding to its receptor, EpoR, on erythroid progenitors leads to rapid activation of the transcription factor Stat5. Previously, fetal anemia and increased apoptosis of fetal liver erythroid progenitors were found in Stat5a/5b/ mice. However, the role of Stat5 in adult erythropoiesis was not clear. The present study shows that some adult Stat5a/5b/ mice have a near-normal hematocrit but are deficient in generating high erythropoietic rates in response to stress. Further, many adult Stat5a/5b/ mice have persistent anemia despite a marked compensatory expansion in their erythropoietic tissue. Analysis of erythroblast maturation in Stat5a/5b/ hematopoietic tissue shows a dramatic increase in early erythroblast numbers, but these fail to progress in differentiation. Decreased expression of bcl-xL and increased apoptosis in Stat5a/5b/ early erythroblasts correlate with the degree of anemia. Hence, Stat5 controls a rate-determining step regulating early erythroblast survival. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B.-M. Zhu, S. K. McLaughlin, R. Na, J. Liu, Y. Cui, C. Martin, A. Kimura, G. W. Robinson, N. C. Andrews, and L. 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