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Blood, 1 December 2001, Vol. 98, No. 12, pp. 3376-3382
IMMUNOBIOLOGY
Development of thymic and splenic dendritic cell populations from
different hemopoietic precursors
Li Wu,
Angela D'Amico,
Hubertus Hochrein,
Meredith O'Keeffe,
Ken Shortman, and
Karen Lucas
From the Walter and Eliza Hall Institute of Medical
Research, P.O. Royal Melbourne Hospital, Victoria,
Australia; and the Institute for Medical Microbiology,
Immunology and Hygiene, Technical University of Munich,
Germany.
The antigen-presenting dendritic cells (DCs) found in mouse
lymphoid tissues are heterogeneous. Several types of DCs have been
identified on the basis of the expression of different surface molecules, including CD4, CD8 , and DEC-205. Previous studies by the authors showed that the mouse intrathymic
lymphoid-restricted precursors
(lin c-kit+Thy-1lowCD4low)
can produce DCs in the thymus and spleen upon intravenous
transfer, suggesting a lymphoid origin of these DCs. In the
current study, the potential for DC production by the newly identified
bone marrow (BM) common lymphoid precursors (CLPs), common myeloid
precursors (CMPs), and committed granulocyte and macrophage precursors
was examined. It was found that both the lymphoid and the myeloid precursors had the potential to produce DCs. All the different DC
populations identified in mouse thymus and spleen could be produced by
all these precursor populations. However, CLPs produced predominantly
the CD4CD8+ DCs, whereas CMPs produced
similar numbers of CD4CD8+ and
CD4+CD8 DCs, although at different peak
times. On a per cell basis, the CLPs were more potent than the CMPs at
DC production, but this may have been compensated for by an excess of
CMPs over CLPs in BM. Overall, this study shows that the expression of
CD8 does not delineate the hemopoietic precursor origin of DCs, and
the nature of the early precursors may bias but does not dictate the phenotype of the DC product.
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