SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kirk, O. Articles by Barton, S. E. Search for Related Content PubMed PubMed Citation Articles by Kirk, O. Articles by Barton, S. E. Related Collections Neoplasia Related Letter in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 December 2001, Vol. 98, No. 12, pp. 3406-3412 NEOPLASIA Non-Hodgkin lymphoma in HIV-infected patients in the era of highly active antiretroviral therapy Ole Kirk, Court Pedersen, Alessandro Cozzi-Lepri, Francisco Antunes, Veronica Miller, Jose M. Gatell, Christine Katlama, Adriano Lazzarin, Peter Skinhøj, and Simon E. Barton for the EuroSIDA Study Group From the EuroSIDA Coordinating Centre, Department of Infectious Diseases, Hvidovre Hospital, Copenhagen, Denmark; Department of Infectious Diseases, Odense University Hospital, Odense, Denmark; Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom; Department of Infectious Diseases, Hospital Santa Maria, Lisbon, Portugal; Zentrum der Inneren Medizin, J. W. Goethe University, Frankfurt, Germany; Servicio Infecciones, Hospital Clinic i Provincial, Barcelona, Spain; Department de Medicine Tropicale, Hopital de la Pitié-Salpêtrière, Paris, France; Department of Infectious Diseases, Ospedale San Raffaele, Milan, Italy; Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark; and St. Stephen's Clinic, Chelsea and Westminster Hospital, London, United Kingdom. This study was designed to assess the influence of highly active antiretroviral therapy (HAART) on non-Hodgkin lymphoma (NHL) among patients infected with human immunodeficiency virus (HIV). Within EuroSIDA, a multicenter observational cohort of more than 8500 patients from across Europe, the incidences of NHL and subtypes (Burkitt, immunoblastic, primary brain lymphoma [PBL], and other/unknown histology) were determined according to calendar time of follow-up, and for those who initiated HAART (3 drugs) also time on HAART. Potential predictive factors of NHL were evaluated in Cox proportional hazard models. Over 26 764 person-years of prospective follow-up (PYF) from May 1994 to December 2000, the incidence of NHL decreased from 1.99 (95% confidence interval, 1.51-2.47) before September 1995 to 0.30 (0.19-0.42) cases/100 (PYF) after March 1999 (P < .001). The incidence of all subtypes of NHL decreased significantly and most pronouncedly for PBL. Among patients who started HAART, the incidence of NHL decreased from 0.88 (0.60-1.16) within the first 12 months after starting HAART to 0.45 (0.31-0.60) cases/100 PYF after more than 24 months (P = .004). In an adjusted Cox model for patients on HAART, the latest CD4 cell count and plasma viral load were both significantly associated with diagnosis of NHL; the relative hazard was 1.39 (range, 1.14-1.69) per 50% lower CD4 cell count, and 1.51 (range, 1.21-1.88) per 1 log higher plasma viral load. In conclusion, the incidence of NHL among HIV-infected patients has decreased significantly after the introduction of HAART, and the decline was most pronounced for PBL. After starting HAART, patients with insufficient immunologic and virologic responses were at highest risk of NHL. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Letter in Blood Online: Systemic non-Hodgkin lymphoma in HIV-infected patients in the era of highly active antiretroviral therapy Regis A. Vilchez, Jeffrey L. Jorgensen, and Michael H. Kroll Blood 2002 99: 4250-4251. [Full Text] [PDF] This article has been cited by other articles: S. Rothschild, M. Dolder, B. Seifert, U. M. Lutolf, and I. F. Ciernik Radiation Therapy for HIV-Associated Diffuse Large Cell Non-Hodgkin Lymphoma J Int Assoc Physicians AIDS Care (Chic Ill), July 1, 2009; 8(4): 239 - 248. [Abstract] [PDF] J. L. Diez-Martin, P. Balsalobre, A. Re, M. Michieli, J. M. Ribera, C. Canals, E. Conde, A. Rosselet, I. Gabriel, R. Varela, et al. Comparable survival between HIV+ and HIV- non-Hodgkin and Hodgkin lymphoma patients undergoing autologous peripheral blood stem cell transplantation Blood, June 4, 2009; 113(23): 6011 - 6014. [Abstract] [Full Text] [PDF] M. Bower, M. Fisher, T. Hill, I. Reeves, J. Walsh, C. Orkin, A. N. Phillips, L. Bansi, R. Gilson, P. Easterbrook, et al. CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK Haematologica, June 1, 2009; 94(6): 875 - 880. [Abstract] [Full Text] [PDF] P. Balsalobre, J. L. Diez-Martin, A. Re, M. Michieli, J. M. Ribera, C. Canals, A. Rosselet, E. Conde, R. Varela, K. Cwynarski, et al. Autologous Stem-Cell Transplantation in Patients With HIV-Related Lymphoma J. Clin. Oncol., May 1, 2009; 27(13): 2192 - 2198. [Abstract] [Full Text] [PDF] J.-P. Spano, D. Costagliola, C. Katlama, N. Mounier, E. Oksenhendler, and D. Khayat AIDS-Related Malignancies: State of the Art and Therapeutic Challenges J. Clin. Oncol., October 10, 2008; 26(29): 4834 - 4842. [Abstract] [Full Text] [PDF] S M Lowe, G I Kocjan, S G Edwards, and R F Miller Diagnostic yield of fine-needle aspiration cytology in HIV-infected patients with lymphadenopathy in the era of highly active antiretroviral therapy Int J STD AIDS, August 1, 2008; 19(8): 553 - 556. [Abstract] [Full Text] [PDF] D. Capello, M. Martini, A. Gloghini, M. Cerri, S. Rasi, C. Deambrogi, D. Rossi, M. Spina, U. Tirelli, L. M. Larocca, et al. Molecular analysis of immunoglobulin variable genes in human immunodeficiency virus-related non-Hodgkin's lymphoma reveals implications for disease pathogenesis and histogenesis Haematologica, August 1, 2008; 93(8): 1178 - 1185. [Abstract] [Full Text] [PDF] J.-T. Navarro, F. Vall-Llovera, J.-L. Mate, M. Morgades, E. Feliu, and J.-M. Ribera Decrease in the frequency of meningeal involvement in AIDS-related systemic lymphoma in patients receiving HAART Haematologica, January 1, 2008; 93(1): 149 - 150. [Abstract] [Full Text] [PDF] L. Galicier, C. Fieschi, R. Borie, V. Meignin, M.-T. Daniel, L. Gerard, and E. Oksenhendler Intensive chemotherapy regimen (LMB86) for St Jude stage IV AIDS-related Burkitt lymphoma/leukemia: a prospective study Blood, October 15, 2007; 110(8): 2846 - 2854. [Abstract] [Full Text] [PDF] S. Combs, N. Neil, and D. M. Aboulafia Liposomal Doxorubicin, Cyclophosphamide, and Etoposide and Antiretroviral Therapy for Patients with AIDS-Related Lymphoma: A Pilot Study. Oncologist, June 1, 2006; 11(6): 666 - 673. [Abstract] [Full Text] [PDF] W. H. Navarro and L. D. Kaplan AIDS-related lymphoproliferative disease Blood, January 1, 2006; 107(1): 13 - 20. [Abstract] [Full Text] [PDF] L. M. Morton, S. S. Wang, S. S. Devesa, P. Hartge, D. D. Weisenburger, and M. S. Linet Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001 Blood, January 1, 2006; 107(1): 265 - 276. [Abstract] [Full Text] [PDF] C. Hoffmann, M. Tiemann, C. Schrader, D. Janssen, E. Wolf, M. Vierbuchen, R. Parwaresch, K. Ernestus, A. Plettenberg, A. Stoehr, et al. AIDS-related B-cell lymphoma (ARL): correlation of prognosis with differentiation profiles assessed by immunophenotyping Blood, September 1, 2005; 106(5): 1762 - 1769. [Abstract] [Full Text] [PDF] E. Piriou, C. A. Jansen, K. v. Dort, I. De Cuyper, N. M. Nanlohy, J. M. A. Lange, M. H. J. van Oers, F. Miedema, and D. van Baarle Reconstitution of EBV Latent but Not Lytic Antigen-Specific CD4+ and CD8+ T Cells after HIV Treatment with Highly Active Antiretroviral Therapy J. Immunol., August 1, 2005; 175(3): 2010 - 2017. [Abstract] [Full Text] [PDF] S. T. Lim and A. M. Levine Recent Advances in Acquired Immunodeficiency Syndrome (AIDS)-related Lymphoma CA Cancer J Clin, July 1, 2005; 55(4): 229 - 241. [Abstract] [Full Text] [PDF] S. T. Lim, R. Karim, B. N. Nathwani, A. Tulpule, B. Espina, and A. M. Levine AIDS-Related Burkitt's Lymphoma Versus Diffuse Large-Cell Lymphoma in the Pre-Highly Active Antiretroviral Therapy (HAART) and HAART Eras: Significant Differences in Survival With Standard Chemotherapy J. Clin. Oncol., July 1, 2005; 23(19): 4430 - 4438. [Abstract] [Full Text] [PDF] M. C. Cheung, L. Pantanowitz, and B. J. Dezube AIDS-Related Malignancies: Emerging Challenges in the Era of Highly Active Antiretroviral Therapy Oncologist, June 1, 2005; 10(6): 412 - 426. [Abstract] [Full Text] [PDF] C. Lewden, D. Salmon, P. Morlat, S. Bevilacqua, E. Jougla, F. Bonnet, L. Heripret, D. Costagliola, T. May, G. Chene, et al. Causes of death among human immunodeficiency virus (HIV)-infected adults in the era of potent antiretroviral therapy: emerging role of hepatitis and cancers, persistent role of AIDS Int. J. Epidemiol., February 1, 2005; 34(1): 121 - 130. [Abstract] [Full Text] [PDF] S. J. Paulsen, M. M. Rosenkilde, J. Eugen-Olsen, and T. N. Kledal Epstein-Barr Virus-Encoded BILF1 Is a Constitutively Active G Protein-Coupled Receptor J. Virol., January 1, 2005; 79(1): 536 - 546. [Abstract] [Full Text] [PDF] G. Toffoli, G. Corona, G. Cattarossi, M. Boiocchi, G. Di Gennaro, U. Tirelli, and E. Vaccher Effect of highly active antiretroviral therapy (HAART) on pharmacokinetics and pharmacodynamics of doxorubicin in patients with HIV-associated non-Hodgkin's lymphoma Ann. Onc., December 1, 2004; 15(12): 1805 - 1809. [Abstract] [Full Text] [PDF] P. Rivailler, A. Carville, A. Kaur, P. Rao, C. Quink, J. L. Kutok, S. Westmoreland, S. Klumpp, M. Simon, J. C. Aster, et al. Experimental rhesus lymphocryptovirus infection in immunosuppressed macaques: an animal model for Epstein-Barr virus pathogenesis in the immunosuppressed host Blood, September 1, 2004; 104(5): 1482 - 1489. [Abstract] [Full Text] [PDF] I. C. Anthony, D. H. Crawford, and J. E. Bell B lymphocytes in the normal brain: contrasts with HIV-associated lymphoid infiltrates and lymphomas Brain, May 1, 2003; 126(5): 1058 - 1067. [Abstract] [Full Text] [PDF] C Bellan, S Lazzi, G De Falco, A Nyongo, A Giordano, and L Leoncini Burkitt's lymphoma: new insights into molecular pathogenesis J. Clin. Pathol., March 1, 2003; 56(3): 188 - 192. [Abstract] [Full Text] [PDF] Changes over calendar time in the risk of specific first AIDS-defining events following HIV seroconversion, adjusting for competing risks Int. J. Epidemiol., October 1, 2002; 31(5): 951 - 958. [Abstract] [Full Text] [PDF] R. A. Vilchez, J. L. Jorgensen, and M. H. Kroll Systemic non-Hodgkin lymphoma in HIV-infected patients in the era of highly active antiretroviral therapy Blood, May 13, 2002; 99(11): 4250 - 4251. [Full Text] [PDF]

	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020