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Blood, 1 December 2001, Vol. 98, No. 12, pp. 3479-3482
BRIEF REPORT
Loss of a novel tumor suppressor gene locus at chromosome 8p is
associated with leukemic mantle cell lymphoma
Jose A. Martinez-Climent,
Esperanza Vizcarra,
Dolors Sanchez,
David Blesa,
Isabel Marugan,
Isabel Benet,
Françesc Sole,
Francisca Rubio-Moscardo,
Maria J. Terol,
Joan Climent,
Elena Sarsotti,
Mar Tormo,
Enrique Andreu,
Marta Salido,
Maria A. Ruiz,
Felipe Prosper,
Reiner Siebert,
Martin J. S. Dyer, and
Javier García-Conde
From the Department of Hematology and Medical Oncology,
Hospital Clínico, University of Valencia, Spain; Laboratory of
Hematologic Cytology, Department of Pathology, Hospital del Mar,
Barcelona, Spain; Section of Hematology, Gandia Hospital, Gandia,
Spain; Institute of Human Genetics, University Hospital Kiel,
Germany; and Department of Haematology, University of Leicester, United
Kingdom.
Patients with mantle cell lymphoma (MCL) may present with either
nodal or leukemic disease. The molecular determinants underlying this
different biologic behavior are not known. This study compared the
pattern of genetic abnormalities in patients with nodal and leukemic
phases of MCL using comparative genomic hybridization (CGH) and
fluorescence in situ hybridization (FISH) for specific gene loci.
Although both leukemic and nodal MCL showed similar genomic patterns of
losses (involving 6q, 11q22-q23, 13q14, and 17p13) and gains (affecting
3q and 8q), genomic loss of chromosome 8p occurred more frequently in
patients with leukemic disease (79% versus 11%,
P < .001). Subsequent CGH analysis confirmed the genomic
loss of 8p21-p23 in 6 of 8 MCL cell lines. Interestingly, MYC gene amplification was restricted to cases with 8p
deletion. These data indicate the presence of a novel tumor suppressor
gene locus on 8p, whose deletion may be associated with leukemic
dissemination and poor prognosis in patients with MCL.
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