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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rachmilewitz, J. Articles by Tykocinski, M. L. Search for Related Content PubMed PubMed Citation Articles by Rachmilewitz, J. Articles by Tykocinski, M. L. Related Collections Immunobiology Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 December 2001, Vol. 98, No. 13, pp. 3727-3732 IMMUNOBIOLOGY A rheostatic mechanism for T-cell inhibition based on elevation of activation thresholds Jacob Rachmilewitz, Gregory J. Riely, Jui-Han Huang, Aoshuang Chen, and Mark L. Tykocinski From the Department of Pathology, Case Western Reserve University, Cleveland, OH. The activation of discrete T-cell responses depends on the triggering of individualized threshold numbers of T-cell receptors (TCRs). The results of this study indicate that the lipocalin placental protein 14 (PP14), a T-cell inhibitor produced by cells of the reproductive and hematopoietic systems, mediates its anti-inflammatory activity by elevating the T-cell activation threshold, thereby rendering T cells less sensitive to stimulation. Significantly, the data demonstrate hierarchical sensitivity of selected cytokine responses to PP14-mediated inhibition, with the hierarchy reflecting their respective activation thresholds. These findings suggest a novel paradigm for immunoinhibition wherein negative regulators can finely tune, rather than inactivate, T-cell responses, and thereby skew the cytokine output of immunologic responses. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. Toth, K. Roth, C. Kunert-Keil, C. Scholz, S. Schulze, I. Mylonas, K. Friese, and U. Jeschke Glycodelin Protein and mRNA Is Downregulated in Human First Trimester Abortion and Partially Upregulated in Mole Pregnancy J. Histochem. Cytochem., May 1, 2008; 56(5): 477 - 485. [Abstract] [Full Text] [PDF] M. Seppala, H. Koistinen, R. Koistinen, P.C.N. Chiu, and W.S.B. Yeung Glycosylation related actions of glycodelin: gamete, cumulus cell, immune cell and clinical associations Hum. Reprod. Update, May 1, 2007; 13(3): 275 - 287. [Abstract] [Full Text] [PDF] E. Ish-Shalom, A. Gargir, S. Andre, Z. Borovsky, Z. Ochanuna, H.-J. Gabius, M. L. Tykocinski, and J. Rachmilewitz {alpha}2,6-Sialylation promotes binding of placental protein 14 via its Ca2+-dependent lectin activity: insights into differential effects on CD45RO and CD45RA T cells Glycobiology, March 1, 2006; 16(3): 173 - 183. [Abstract] [Full Text] [PDF] K. Lapid and N. Sharon Meet the multifunctional and sexy glycoforms of glycodelin Glycobiology, March 1, 2006; 16(3): 39R - 45R. [Abstract] [Full Text] [PDF] P. M. Lavoie, A. R. Dumont, H. McGrath, A.-E. Kernaleguen, and R.-P. Sekaly Delayed expansion of a restricted T cell repertoire by low-density TCR ligands Int. Immunol., July 1, 2005; 17(7): 931 - 941. [Abstract] [Full Text] [PDF] G. Mishan-Eisenberg, Z. Borovsky, M. C. Weber, R. Gazit, M. L. Tykocinski, and J. Rachmilewitz Differential Regulation of Th1/Th2 Cytokine Responses by Placental Protein 14 J. Immunol., November 1, 2004; 173(9): 5524 - 5530. [Abstract] [Full Text] [PDF] E. Mandelin, H. Lassus, M. Seppala, A. Leminen, J.-A. Gustafsson, G. Cheng, R. Butzow, and R. Koistinen Glycodelin in Ovarian Serous Carcinoma: Association with Differentiation and Survival Cancer Res., October 1, 2003; 63(19): 6258 - 6264. [Abstract] [Full Text] [PDF] J. Rachmilewitz, Z. Borovsky, G. J. Riely, R. Miller, and M. L. Tykocinski Negative Regulation of T Cell Activation by Placental Protein 14 Is Mediated by the Tyrosine Phosphatase Receptor CD45 J. Biol. Chem., April 11, 2003; 278(16): 14059 - 14065. [Abstract] [Full Text] [PDF] M. Seppala, R. N. Taylor, H. Koistinen, R. Koistinen, and E. Milgrom Glycodelin: A Major Lipocalin Protein of the Reproductive Axis with Diverse Actions in Cell Recognition and Differentiation Endocr. Rev., August 1, 2002; 23(4): 401 - 430. [Abstract] [Full Text] [PDF] J. Rachmilewitz, Z. Borovsky, G. Mishan-Eisenberg, E. Yaniv, G. J. Riely, and M. L. Tykocinski Focal Localization of Placental Protein 14 Toward Sites of TCR Engagement J. Immunol., March 15, 2002; 168(6): 2745 - 2750. [Abstract] [Full Text] [PDF]

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