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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Schmitz, J. E. Articles by Letvin, N. L. Search for Related Content PubMed PubMed Citation Articles by Schmitz, J. E. Articles by Letvin, N. L. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 December 2001, Vol. 98, No. 13, pp. 3757-3761 IMMUNOBIOLOGY Simian immunodeficiency virus (SIV)-specific cytotoxic T lymphocytes in gastrointestinal tissues of chronically SIV-infected rhesus monkeys Jörn E. Schmitz, Ronald S. Veazey, Marcelo J. Kuroda, Daniel B. Levy, Aruna Seth, Keith G. Mansfield, Christine E. Nickerson, Michelle A. Lifton, Xavier Alvarez, Andrew A. Lackner, and Norman L. Letvin From the Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, and New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts. Although systemic virus-specific cytotoxic T lymphocyte (CTL) responses are of critical importance in controlling virus replication in individuals infected with human immunodeficiency virus 1 (HIV-1), little is known about this immune response in the gastrointestinal (GI) tract. This study investigated the GI tract CTL response in a nonhuman primate model for HIV-1 infection, simian immunodeficiency virus (SIV)-infected rhesus monkeys. Lymphocytes from duodenal pinch biopsy specimens were obtained from 9 chronically SIVmac-infected rhesus monkeys and GI tract lymphocytes were harvested from the jejunum and ileum of 4 euthanized SIVmac-infected rhesus monkeys. Lymphocytes were also assessed in GI mucosal tissues by in situ staining in histologic specimens. SIVmac Gag-specific CTLs were assessed in the monkeys using the tetramer technology. These GI mucosal tissues of chronically SIVmac-infected rhesus monkeys contained levels of CTLs comparable to those found in the peripheral blood and lymph nodes. The present studies suggest that the CD8+ CTL response in GI mucosal sites is comparable to that seen systemically in SIVmac-infected rhesus monkeys. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. D. George, D. Verhoeven, S. Sankaran, T. Glavan, E. Reay, and S. Dandekar Heightened Cytotoxic Responses and Impaired Biogenesis Contribute to Early Pathogenesis in the Oral Mucosa of Simian Immunodeficiency Virus-Infected Rhesus Macaques Clin. Vaccine Immunol., February 1, 2009; 16(2): 277 - 281. [Abstract] [Full Text] [PDF] R. S. Veazey, P. M. Acierno, K. J. McEvers, S. H. C. Baumeister, G. J. Foster, M. D. Rett, M. H. Newberg, M. J. Kuroda, K. Williams, E.-Y. Kim, et al. Increased Loss of CCR5+ CD45RA- CD4+ T Cells in CD8+ Lymphocyte-Depleted Simian Immunodeficiency Virus-Infected Rhesus Monkeys J. Virol., June 1, 2008; 82(11): 5618 - 5630. [Abstract] [Full Text] [PDF] Y. M. Mueller, C. Petrovas, D. H. Do, S. R. Altork, T. Fischer-Smith, J. Rappaport, J. D. Altman, M. G. Lewis, and P. D. Katsikis Early Establishment and Antigen Dependence of Simian Immunodeficiency Virus-Specific CD8+ T-Cell Defects J. Virol., October 15, 2007; 81(20): 10861 - 10868. [Abstract] [Full Text] [PDF] J. Zhu, D. M. Koelle, J. Cao, J. Vazquez, M. L. Huang, F. 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	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020