|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 August 2001, Vol. 98, No. 3, pp. 643-651
HEMATOPOIESIS
Myelopoiesis in the zebrafish, Danio
rerio
Carolyn M. Bennett,
John P. Kanki,
Jennifer Rhodes,
Ting X. Liu,
Barry H. Paw,
Mark W. Kieran,
David M. Langenau,
Anne Delahaye-Brown,
Leonard I. Zon,
Mark D. Fleming, and
A. Thomas Look
From the Department of Pediatric Oncology, Dana-Farber
Cancer Institute; Departments of Medicine and Pathology, Children's
Hospital; and Howard Hughes Medical Institute, Children's Hospital,
Boston, MA.
Genome-wide chemical mutagenesis screens in the zebrafish
(Danio rerio) have led to the identification of novel genes
affecting vertebrate erythropoiesis. In determining if this approach
could also be used to clarify the molecular genetics of myelopoiesis, it was found that the developmental hierarchy of myeloid precursors in
the zebrafish kidney is similar to that in human bone marrow. Zebrafish
neutrophils resembled human neutrophils, possessing segmented nuclei
and myeloperoxidase-positive cytoplasmic granules. The zebrafish
homologue of the human myeloperoxidase (MPO) gene, which is
specific to cells of the neutrophil lineage, was cloned and used to
synthesize antisense RNA probes for in situ hybridization analyses of
zebrafish embryos. Granulocytic cells expressing zebrafish mpo were first evident at 18 hours after fertilization
(hpf) in the posterior intermediate cell mass (ICM) and on the anterior yolk sac by 20 hpf. By 24 hpf, mpo-expressing cells were
observed along the ICM and within the developing vascular system. Thus, the mpo gene should provide a useful molecular probe for
identifying zebrafish mutants with defects in granulopoiesis. The
expression of zebrafish homologues was also examined in 2 other
mammalian hematopoietic genes, Pu.1, which appears to
initiate a commitment step in normal mammalian myeloid development, and
L-Plastin, a gene expressed by human monocytes and
macrophages. The results demonstrate a high level of conservation of
the spatio-temporal expression patterns of these genes between
zebrafish and mammals. The morphologic and molecular genetic evidence
presented here supports the zebrafish as an informative model system
for the study of normal and aberrant human myelopoiesis.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
H.-Y. Le, Y. Zhang, H. Liu, L.-H. Ma, Y. Jin, Q.-H. Huang, Y. Chen, M. Deng, Z. Chen, S.-J. Chen, et al.
eena Promotes Myeloid Proliferation through Stimulating ERK1/2 Phosphorylation in Zebrafish
J. Biol. Chem.,
June 20, 2008;
283(25):
17652 - 17661.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Sumanas, G. Gomez, Y. Zhao, C. Park, K. Choi, and S. Lin
Interplay among Etsrp/ER71, Scl, and Alk8 signaling controls endothelial and myeloid cell formation
Blood,
May 1, 2008;
111(9):
4500 - 4510.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Dayyani, J. Wang, J.-R. J. Yeh, E.-Y. Ahn, E. Tobey, D.-E. Zhang, I. D. Bernstein, R. T. Peterson, and D. A. Sweetser
Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival
Blood,
April 15, 2008;
111(8):
4338 - 4347.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Carradice and G. J. Lieschke
Zebrafish in hematology: sushi or science?
Blood,
April 1, 2008;
111(7):
3331 - 3342.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-R. J. Yeh, K. M. Munson, Y. L. Chao, Q. P. Peterson, C. A. MacRae, and R. T. Peterson
AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression
Development,
January 15, 2008;
135(2):
401 - 410.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Le Guyader, M. J. Redd, E. Colucci-Guyon, E. Murayama, K. Kissa, V. Briolat, E. Mordelet, A. Zapata, H. Shinomiya, and P. Herbomel
Origins and unconventional behavior of neutrophils in developing zebrafish
Blood,
January 1, 2008;
111(1):
132 - 141.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kalujnaia, I. S. McWilliam, V. A. Zaguinaiko, A. L. Feilen, J. Nicholson, N. Hazon, C. P. Cutler, and G. Cramb
Transcriptomic approach to the study of osmoregulation in the European eel Anguilla anguilla
Physiol Genomics,
November 14, 2007;
31(3):
385 - 401.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Mathias, M. E. Dodd, K. B. Walters, J. Rhodes, J. P. Kanki, A. T. Look, and A. Huttenlocher
Live imaging of chronic inflammation caused by mutation of zebrafish Hai1
J. Cell Sci.,
October 1, 2007;
120(19):
3372 - 3383.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Liu, L. Du, M. Osato, E. H. Teo, F. Qian, H. Jin, F. Zhen, J. Xu, L. Guo, H. Huang, et al.
The zebrafish udu gene encodes a novel nuclear factor and is essential for primitive erythroid cell development
Blood,
July 1, 2007;
110(1):
99 - 106.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Le, D. M. Langenau, M. D. Keefe, J. L. Kutok, D. S. Neuberg, and L. I. Zon
Heat shock-inducible Cre/Lox approaches to induce diverse types of tumors and hyperplasia in transgenic zebrafish
PNAS,
May 29, 2007;
104(22):
9410 - 9415.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Patterson, M. Gering, C. E. Eckfeldt, A. R. Green, C. M. Verfaillie, S. C. Ekker, and R. Patient
The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish
Blood,
March 15, 2007;
109(6):
2389 - 2398.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Grabher, A. Cliffe, K. Miura, J. Hayflick, R. Pepperkok, P. Rorth, and J. Wittbrodt
Birth and life of tissue macrophages and their migration in embryogenesis and inflammation in medaka
J. Leukoc. Biol.,
January 1, 2007;
81(1):
263 - 271.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Renshaw, C. A. Loynes, D. M.I. Trushell, S. Elworthy, P. W. Ingham, and M. K.B. Whyte
A transgenic zebrafish model of neutrophilic inflammation
Blood,
December 15, 2006;
108(13):
3976 - 3978.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Mathias, B. J. Perrin, T.-X. Liu, J. Kanki, A. T. Look, and A. Huttenlocher
Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish
J. Leukoc. Biol.,
December 1, 2006;
80(6):
1281 - 1288.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. R. L. Young, C. Mumaw, J. A. Marrs, and D. G. Skalnik
Antisense Targeting of CXXC Finger Protein 1 Inhibits Genomic Cytosine Methylation and Primitive Hematopoiesis in Zebrafish
J. Biol. Chem.,
December 1, 2006;
281(48):
37034 - 37044.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. E. Sabaawy, M. Azuma, L. J. Embree, H.-J. Tsai, M. F. Starost, and D. D. Hickstein
TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia
PNAS,
October 10, 2006;
103(41):
15166 - 15171.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Schorpp, M. Bialecki, D. Diekhoff, B. Walderich, J. Odenthal, H.-M. Maischein, A. G. Zapata, Tubingen 2000 Screen Consortium, Freiburg Screening Group, and T. Boehm
Conserved Functions of Ikaros in Vertebrate Lymphocyte Development: Genetic Evidence for Distinct Larval and Adult Phases of T Cell Development and Two Lineages of B Cells in Zebrafish
J. Immunol.,
August 15, 2006;
177(4):
2463 - 2476.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Gupta, H. Zhu, L. I. Zon, and T. Evans
BMP signaling restricts hemato-vascular development from lateral mesoderm during somitogenesis
Development,
June 1, 2006;
133(11):
2177 - 2187.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. van der Sar, O. W. Stockhammer, C. van der Laan, H. P. Spaink, W. Bitter, and A. H. Meijer
MyD88 Innate Immune Function in a Zebrafish Embryo Infection Model
Infect. Immun.,
April 1, 2006;
74(4):
2436 - 2441.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Juarez, F. Su, S. Chun, M. J. Kiel, and S. E. Lyons
Distinct Roles for SCL in Erythroid Specification and Maturation in Zebrafish
J. Biol. Chem.,
December 16, 2005;
280(50):
41636 - 41644.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-F. Lin, D. Traver, H. Zhu, K. Dooley, B. H. Paw, L. I. Zon, and R. I. Handin
Analysis of thrombocyte development in CD41-GFP transgenic zebrafish
Blood,
December 1, 2005;
106(12):
3803 - 3810.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. J. Weber, S. E. Choe, K. A. Dooley, N. N. Paffett-Lugassy, Y. Zhou, and L. I. Zon
Mutant-specific gene programs in the zebrafish
Blood,
July 15, 2005;
106(2):
521 - 530.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. Craven, D. French, W. Ye, F. de Sauvage, and A. Rosenthal
Loss of Hspa9b in zebrafish recapitulates the ineffective hematopoiesis of the myelodysplastic syndrome
Blood,
May 1, 2005;
105(9):
3528 - 3534.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Langenau, C. Jette, S. Berghmans, T. Palomero, J. P. Kanki, J. L. Kutok, and A. T. Look
Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish
Blood,
April 15, 2005;
105(8):
3278 - 3285.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Berghmans, R. D. Murphey, E. Wienholds, D. Neuberg, J. L. Kutok, C. D. M. Fletcher, J. P. Morris, T. X. Liu, S. Schulte-Merker, J. P. Kanki, et al.
tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors
PNAS,
January 11, 2005;
102(2):
407 - 412.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-D. Song, X.-J. Sun, M. Deng, G.-W. Zhang, Y. Zhou, X.-Y. Wu, Y. Sheng, Y. Chen, Z. Ruan, C.-L. Jiang, et al.
Hematopoietic gene expression profile in zebrafish kidney marrow
PNAS,
November 16, 2004;
101(46):
16240 - 16245.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. W. Yang, J. L. Kutok, N. H. Lee, H. Y. Piao, C. D. M. Fletcher, J. P. Kanki, and A. T. Look
Targeted Expression of Human MYCN Selectively Causes Pancreatic Neuroendocrine Tumors in Transgenic Zebrafish
Cancer Res.,
October 15, 2004;
64(20):
7256 - 7262.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Hsu, D. Traver, J. L. Kutok, A. Hagen, T.-X. Liu, B. H. Paw, J. Rhodes, J. N. Berman, L. I. Zon, J. P. Kanki, et al.
The pu.1 promoter drives myeloid gene expression in zebrafish
Blood,
September 1, 2004;
104(5):
1291 - 1297.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Langenau, A. A. Ferrando, D. Traver, J. L. Kutok, J.-P. D. Hezel, J. P. Kanki, L. I. Zon, A. T. Look, and N. S. Trede
In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish
PNAS,
May 11, 2004;
101(19):
7369 - 7374.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Ward, D. O. McPhee, M. M. Condron, S. Varma, S. H. Cody, S. M. N. Onnebo, B. H. Paw, L. I. Zon, and G. J. Lieschke
The zebrafish spi1 promoter drives myeloid-specific expression in stable transgenic fish
Blood,
November 1, 2003;
102(9):
3238 - 3240.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Langenau, D. Traver, A. A. Ferrando, J. L. Kutok, J. C. Aster, J. P. Kanki, S. Lin, E. Prochownik, N. S. Trede, L. I. Zon, et al.
Myc-Induced T Cell Leukemia in Transgenic Zebrafish
Science,
February 7, 2003;
299(5608):
887 - 890.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Spitsbergen and M. L. Kent
The State of the Art of the Zebrafish Model for Toxicology and Toxicologic Pathology Research--Advantages and Current Limitations
Toxicol Pathol,
January 1, 2003;
31(1_suppl):
62 - 87.
[Abstract]
[PDF]
|
|
|
|
|
|
|
Z. Lian, Y. Kluger, D. S. Greenbaum, D. Tuck, M. Gerstein, N. Berliner, S. M. Weissman, and P. E. Newburger
Genomic and proteomic analysis of the myeloid differentiation program: global analysis of gene expression during induced differentiation in the MPRO cell line
Blood,
October 16, 2002;
100(9):
3209 - 3220.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. X. Liu, Y. Zhou, J. P. Kanki, M. Deng, J. Rhodes, H. W. Yang, X. M. Sheng, L. I. Zon, and A. T. Look
Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies
PNAS,
April 30, 2002;
99(9):
6136 - 6141.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. C. Liao, N. S. Trede, D. Ransom, A. Zapata, M. Kieran, and L. I. Zon
Non-cell autonomous requirement for the bloodless gene in primitive hematopoiesis of zebrafish
Development,
January 2, 2002;
129(3):
649 - 659.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
