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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Shi, J. Articles by Ohashi, T. Search for Related Content PubMed PubMed Citation Articles by Shi, J. Articles by Ohashi, T. Related Collections Phagocytes Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 August 2001, Vol. 98, No. 4, pp. 1226-1230 PHAGOCYTES Role of the liver in regulating numbers of circulating neutrophils Jialan Shi, Gary E. Gilbert, Yoshihiro Kokubo, and Takashi Ohashi From the Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Epidemiology, Department of Immunotherapeutics, Tokyo Medical and Dental University, Tokyo, Japan. Neutrophils (polymorphonuclear leukocytes [PMNs]) carry potent destructive enzymes that can destroy invasive bacteria or damage normal tissue. PMNs have a half-life of only 6 hours in the blood, but the details of this homeostasis are unknown. In a rat model of endotoxemia, P-selectin was selectively up-regulated in hepatic sinusoids and veins where it was necessary for phagocytosis of PMNs by Kupffer cells in the liver, as opposed to the spleen or the lungs. Apoptotic PMNs appeared in the lungs and spleen only after inactivation of Kupffer cells by gadolinium chloride (GdCl3). Blocking of Fas protein reduced the number of apoptotic cells in the liver; binding of annexin V to phosphatidylserine (PS) reduced the number of PMNs phagocytosed by Kupffer cells. The results support a clearance pathway in which apoptosis and phagocytosis are effected by Kupffer cells after P-selectin-mediated sequestration. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. R. Stowell, Y. Qian, S. Karmakar, N. S. Koyama, M. Dias-Baruffi, H. Leffler, R. P. McEver, and R. D. Cummings Differential Roles of Galectin-1 and Galectin-3 in Regulating Leukocyte Viability and Cytokine Secretion J. Immunol., March 1, 2008; 180(5): 3091 - 3102. [Abstract] [Full Text] [PDF] S. R. Stowell, S. Karmakar, C. J. Stowell, M. Dias-Baruffi, R. P. McEver, and R. D. Cummings Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells Blood, January 1, 2007; 109(1): 219 - 227. [Abstract] [Full Text] [PDF] J. M. Daley, T. Ivanenko-Johnston, J. S. Reichner, and J. E. Albina Transcriptional regulation of TNF-{alpha} production in neutropenia Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2005; 288(2): R409 - R412. [Abstract] [Full Text] [PDF] H. A. Prins, C. Meijer, P. G. Boelens, R. J. Nijveldt, M. P. C. Siroen, S. Masson, M. Daveau, M. Scotte, J. Diks, and P. A. M. van Leeuwen The Role of Kupffer Cells After Major Liver Surgery JPEN J Parenter Enteral Nutr, January 1, 2005; 29(1): 48 - 55. [Abstract] [Full Text] [PDF] G. Bobe, J. W. Young, and D. C. Beitz Invited Review: Pathology, Etiology, Prevention, and Treatment of Fatty Liver in Dairy Cows J Dairy Sci, October 1, 2004; 87(10): 3105 - 3124. [Abstract] [Full Text] [PDF] B. T. Suratt, J. M. Petty, S. K. Young, K. C. Malcolm, J. G. Lieber, J. A. Nick, J.-A. Gonzalo, P. M. Henson, and G. S. Worthen Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis Blood, July 15, 2004; 104(2): 565 - 571. [Abstract] [Full Text] [PDF] F. Goepel, P. Weinmann, J. Schymeinsky, and B. Walzog Identification of caspase-10 in human neutrophils and its role in spontaneous apoptosis J. Leukoc. Biol., May 1, 2004; 75(5): 836 - 843. [Abstract] [Full Text] [PDF] M. Dias-Baruffi, H. Zhu, M. Cho, S. Karmakar, R. P. McEver, and R. D. Cummings Dimeric Galectin-1 Induces Surface Exposure of Phosphatidylserine and Phagocytic Recognition of Leukocytes without Inducing Apoptosis J. Biol. Chem., October 17, 2003; 278(42): 41282 - 41293. [Abstract] [Full Text] [PDF] P. Weinmann, K. Scharffetter-Kochanek, S. B. Forlow, T. Peters, and B. Walzog A role for apoptosis in the control of neutrophil homeostasis in the circulation: insights from CD18-deficient mice Blood, January 15, 2003; 101(2): 739 - 746. [Abstract] [Full Text] [PDF] S. H. Gregory and E. J. Wing Neutrophil-Kupffer cell interaction: a critical component of host defenses to systemic bacterial infections J. Leukoc. Biol., August 1, 2002; 72(2): 239 - 248. [Abstract] [Full Text] [PDF]

	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020