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Related Collections Neoplasia Plenary Papers Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 August 2001, Vol. 98, No. 4, pp. 906-912 PLENARY PAPER Depletion of circulating natural type 1 interferon-producing cells in HIV-infected AIDS patients Vassili Soumelis, Iain Scott, Ferdous Gheyas, Damien Bouhour, Gregoire Cozon, Laurent Cotte, Laurence Huang, Jay A. Levy, and Yong-Jun Liu From the Department of Immunobiology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA; Department of Medicine, University of California San Francisco; Department of Biostatistics, Schering-Plough Research Institute, Kenilworth, NJ; Hospices Civils de Lyon, Lyon, France; San Francisco General Hospital, CA. Natural interferon- producing cells (IPCs) are a newly characterized blood cell type, which is the major source of type I interferons in antiviral innate immune responses. The relationship between the number of circulating IPCs, HIV disease progression, and the occurrence of HIV-related complications was investigated. The study of 25 healthy donors and 54 HIV-infected subjects demonstrated a direct correlation between blood IPC number, interferon- production, and clinical state of HIV-infected subjects. Asymptomatic long-term survivors had increased IPC number and function relative to uninfected controls and infected individuals with progressive disease. IPC numbers were markedly reduced in AIDS patients developing opportunistic infections and cancer. A negative correlation was found between the IPC number in the blood and the HIV viral load, suggesting that IPCs are important in controlling HIV replication. This study provides the first evidence that IPCs are being affected during the course of HIV infection and suggests that these cells can play a vital role in the protection against opportunistic pathogens and cancer. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. J. Conry, K. A. Milkovich, N. L. Yonkers, B. Rodriguez, H. B. Bernstein, R. Asaad, F. P. Heinzel, M. Tary-Lehmann, M. M. Lederman, and D. D. Anthony Impaired Plasmacytoid Dendritic Cell (PDC)-NK Cell Activity in Viremic Human Immunodeficiency Virus Infection Attributable to Impairments in both PDC and NK Cell Function J. Virol., November 1, 2009; 83(21): 11175 - 11187. [Abstract] [Full Text] [PDF] G. Stary, I. Klein, S. Kohlhofer, F. Koszik, T. Scherzer, L. Mullauer, H. Quendler, N. Kohrgruber, and G. 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