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Related Collections Plenary Papers Hematopoiesis Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 September 2001, Vol. 98, No. 5, pp. 1289-1297 PLENARY PAPER Vascular cell adhesion molecule-1 (CD106) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor Jean-Pierre Lévesque, Yasushi Takamatsu, Susan K. Nilsson, David N. Haylock, and Paul J. Simmons From the Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia. Mobilized progenitor cells currently represent the most commonly used source of hematopoietic progenitor cells (HPCs) to effect hematopoietic reconstitution following myeloablative chemotherapies. Despite their widespread use, the molecular mechanisms responsible for the enforced egress of HPCs from the bone marrow (BM) into the circulation in response to mobilizing agents such as cytokines remain to be determined. Results of this study indicate that expression of vascular cell adhesion molecule-1 (VCAM-1) is strongly reduced in vivo in the BM during HPC mobilization by granulocyte colony-stimulating factor (G-CSF) and stem cell factor. Two serine proteases, namely, neutrophil elastase and cathepsin G, were identified, which cleave VCAM-1 and are released by neutrophils accumulating in the BM during the course of immobilization induced by G-CSF. The proposal is made that an essential step contributing to the mobilization of HPCs is the proteolytic cleavage of VCAM-1 expressed by BM stromal cells, an event triggered by the degranulation of neutrophils accumulating in the BM in response to the administration of G-CSF. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Reca, D. Cramer, J. Yan, M. J. Laughlin, A. Janowska-Wieczorek, J. Ratajczak, and M. Z. Ratajczak A Novel Role of Complement in Mobilization: Immunodeficient Mice Are Poor Granulocyte-Colony Stimulating Factor Mobilizers Because They Lack Complement-Activating Immunoglobulins Stem Cells, December 1, 2007; 25(12): 3093 - 3100. [Abstract] [Full Text] [PDF] S. MENDEZ-FERRER and P. S. FRENETTE Hematopoietic Stem Cell Trafficking: Regulated Adhesion and Attraction to Bone Marrow Microenvironment Ann. N.Y. Acad. 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