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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lee, Y. T. Articles by Miller, J. L. Search for Related Content PubMed PubMed Citation Articles by Lee, Y. T. Articles by Miller, J. L. Related Collections Neoplasia Gene Expression Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 September 2001, Vol. 98, No. 6, pp. 1914-1921 NEOPLASIA Transcription patterning of uncoupled proliferation and differentiation in myelodysplastic bone marrow with erythroid-focused arrays Y. Terry Lee, Lance D. Miller, Alexander N. Gubin, Fairouz Makhlouf, Urszula Wojda, A. John Barrett, Edison T. Liu, and Jeffery L. Miller From the Laboratory of Chemical Biology, National Institute of Diabetes and Digestive and Kidney Diseases; Section of Molecular Signaling and Oncogenesis, Division of Clinical Sciences, National Cancer Institute; Center for Information Technology; and Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD. Because abnormal erythroid differentiation is the most common manifestation of the myelodysplastic syndromes (MDS), it was hypothesized that erythroid gene expression may be used to illustrate myelodysplastic transcription patterns. Ten normal bone marrow aspirates (NBM) were first analyzed using an erythroid-focused cDNA array to define steady-state transcription levels. Proliferation and differentiation gene subsets were identified by statistically significant differences between NBM and erythroleukemia gene expression. Next, cDNAs from 5 separate MDS aspirates were studied: refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation (RAEB-T), and RAEB-T/secondary MDS. A distinct pattern of significantly increased proliferation-associated and reduced differentiation-associated gene activity was established for MDS. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. A. Keller, S. Addya, R. Vadigepalli, B. Banini, K. Delgrosso, H. Huang, and S. Surrey Transcriptional regulatory network analysis of developing human erythroid progenitors reveals patterns of coregulation and potential transcriptional regulators Physiol Genomics, December 13, 2006; 28(1): 114 - 128. [Abstract] [Full Text] [PDF] B. L. Ebert and T. R. Golub Genomic approaches to hematologic malignancies Blood, August 15, 2004; 104(4): 923 - 932. [Abstract] [Full Text] [PDF] W.-K. Hofmann, S. de Vos, M. Komor, D. Hoelzer, W. Wachsman, and H. P. Koeffler Characterization of gene expression of CD34+ cells from normal and myelodysplastic bone marrow Blood, November 15, 2002; 100(10): 3553 - 3560. [Abstract] [Full Text] [PDF]

	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020